Exercise-induced increases of corticosterone contribute to exercise-enhanced adult hippocampal neurogenesis in mice
Adult hippocampal neurogenesis (AHN) is suppressed by chronic stress. The negative effect of stress is mainly attributed to increased levels of stress hormones (e.g. glucocorticoids, GCs). Exercise enhances AHN, yet it also stimulates GC secretion. To delineate the paradoxical role of GCs, we took t...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Chinese Journal of Physiology |
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| Online Access: | http://www.cjphysiology.org/article.asp?issn=0304-4920;year=2021;volume=64;issue=4;spage=186;epage=193;aulast=Wang |
| _version_ | 1818567715152986112 |
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| author | Tzu-Feng Wang Sheng-Feng Tsai Zi-Wei Zhao Monica Meng-Chun Shih Chia-Yih Wang Ting-Ting Yang Yu-Min Kuo |
| author_facet | Tzu-Feng Wang Sheng-Feng Tsai Zi-Wei Zhao Monica Meng-Chun Shih Chia-Yih Wang Ting-Ting Yang Yu-Min Kuo |
| author_sort | Tzu-Feng Wang |
| collection | DOAJ |
| description | Adult hippocampal neurogenesis (AHN) is suppressed by chronic stress. The negative effect of stress is mainly attributed to increased levels of stress hormones (e.g. glucocorticoids, GCs). Exercise enhances AHN, yet it also stimulates GC secretion. To delineate the paradoxical role of GCs, we took the advantage of a unique mouse strain (L/L) which exhibits an inert response to stress-induced secretion of GCs to study the role of GCs in exercise-induced AHN. Our results showed that basal corticosterone (CORT), the main GCs in rodents, levels were similar between the L/L mice and wild-type (WT) mice. However, levels of CORT in the L/L mice were barely altered and significantly lower than those of the WT mice during treadmill running (TR). AHN was enhanced by 4 weeks of TR in the WT mice, but not L/L mice. WT mice that received daily injection of CORT to evoke serum CORT levels similar to those during exercise for 4 weeks did not affect AHN, whereas injection with large amount of CORT inhibited AHN. Taken together, our results indicated that exercise-related elevation of CORT participates in exercise-enhanced AHN. CORT alone is not sufficient to elicit AHN and may inhibit AHN if the levels are high. |
| first_indexed | 2024-12-14T06:26:56Z |
| format | Article |
| id | doaj.art-38ddc1c5a87347909d5d3b0d206335b8 |
| institution | Directory Open Access Journal |
| issn | 0304-4920 2666-0059 |
| language | English |
| last_indexed | 2024-12-14T06:26:56Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Chinese Journal of Physiology |
| spelling | doaj.art-38ddc1c5a87347909d5d3b0d206335b82022-12-21T23:13:39ZengWolters Kluwer Medknow PublicationsChinese Journal of Physiology0304-49202666-00592021-01-0164418619310.4103/cjp.cjp_39_21Exercise-induced increases of corticosterone contribute to exercise-enhanced adult hippocampal neurogenesis in miceTzu-Feng WangSheng-Feng TsaiZi-Wei ZhaoMonica Meng-Chun ShihChia-Yih WangTing-Ting YangYu-Min KuoAdult hippocampal neurogenesis (AHN) is suppressed by chronic stress. The negative effect of stress is mainly attributed to increased levels of stress hormones (e.g. glucocorticoids, GCs). Exercise enhances AHN, yet it also stimulates GC secretion. To delineate the paradoxical role of GCs, we took the advantage of a unique mouse strain (L/L) which exhibits an inert response to stress-induced secretion of GCs to study the role of GCs in exercise-induced AHN. Our results showed that basal corticosterone (CORT), the main GCs in rodents, levels were similar between the L/L mice and wild-type (WT) mice. However, levels of CORT in the L/L mice were barely altered and significantly lower than those of the WT mice during treadmill running (TR). AHN was enhanced by 4 weeks of TR in the WT mice, but not L/L mice. WT mice that received daily injection of CORT to evoke serum CORT levels similar to those during exercise for 4 weeks did not affect AHN, whereas injection with large amount of CORT inhibited AHN. Taken together, our results indicated that exercise-related elevation of CORT participates in exercise-enhanced AHN. CORT alone is not sufficient to elicit AHN and may inhibit AHN if the levels are high.http://www.cjphysiology.org/article.asp?issn=0304-4920;year=2021;volume=64;issue=4;spage=186;epage=193;aulast=Wangadult hippocampal neurogenesiscorticosteroneexerciseglucocorticoidsstress |
| spellingShingle | Tzu-Feng Wang Sheng-Feng Tsai Zi-Wei Zhao Monica Meng-Chun Shih Chia-Yih Wang Ting-Ting Yang Yu-Min Kuo Exercise-induced increases of corticosterone contribute to exercise-enhanced adult hippocampal neurogenesis in mice Chinese Journal of Physiology adult hippocampal neurogenesis corticosterone exercise glucocorticoids stress |
| title | Exercise-induced increases of corticosterone contribute to exercise-enhanced adult hippocampal neurogenesis in mice |
| title_full | Exercise-induced increases of corticosterone contribute to exercise-enhanced adult hippocampal neurogenesis in mice |
| title_fullStr | Exercise-induced increases of corticosterone contribute to exercise-enhanced adult hippocampal neurogenesis in mice |
| title_full_unstemmed | Exercise-induced increases of corticosterone contribute to exercise-enhanced adult hippocampal neurogenesis in mice |
| title_short | Exercise-induced increases of corticosterone contribute to exercise-enhanced adult hippocampal neurogenesis in mice |
| title_sort | exercise induced increases of corticosterone contribute to exercise enhanced adult hippocampal neurogenesis in mice |
| topic | adult hippocampal neurogenesis corticosterone exercise glucocorticoids stress |
| url | http://www.cjphysiology.org/article.asp?issn=0304-4920;year=2021;volume=64;issue=4;spage=186;epage=193;aulast=Wang |
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