A MAC2-positive progenitor-like microglial population is resistant to CSF1R inhibition in adult mouse brain

A MAC2-positive progenitor-like microglial population is resistant to CSF1R inhibition in adult mouse brain

Microglia are the resident myeloid cells in the central nervous system (CNS). The majority of microglia rely on CSF1R signaling for survival. However, a small subset of microglia in mouse brains can survive without CSF1R signaling and reestablish the microglial homeostatic population after CSF1R sig...

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Bibliographic Details
Main Authors: Lihong Zhan, Li Fan, Lay Kodama, Peter Dongmin Sohn, Man Ying Wong, Gergey Alzaem Mousa, Yungui Zhou, Yaqiao Li, Li Gan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-10-01
Series:eLife
Subjects:
microglia
adult microglial progenitors
csf1r signaling
Mac2
microglia homeostasis
myeloid cells
Online Access:https://elifesciences.org/articles/51796

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