Epidemiology of fungal infections in liver transplant recipients: a six-year study of a large Brazilian liver transplantation centre
Liver transplant seems to be an effective option to prolong survival in patients with end-stage liver disease, although it still can be followed by serious complications. Invasive fungal infections (ifi) are related to high rates of morbidity and mortality. The epidemiology of fungal infections in B...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2011-05-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000300014&lng=en&tlng=en |
| _version_ | 1827880154908590080 |
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| author | Michelle Zicker Arnaldo Lopes Colombo Ben-Hur Ferraz-Neto Luis Fernando Aranha Camargo |
| author_facet | Michelle Zicker Arnaldo Lopes Colombo Ben-Hur Ferraz-Neto Luis Fernando Aranha Camargo |
| author_sort | Michelle Zicker |
| collection | DOAJ |
| description | Liver transplant seems to be an effective option to prolong survival in patients with end-stage liver disease, although it still can be followed by serious complications. Invasive fungal infections (ifi) are related to high rates of morbidity and mortality. The epidemiology of fungal infections in Brazilian liver transplant recipients is unknown. The aim of this observational and retrospective study was to determine the incidence and epidemiology of fungal infections in all patients who underwent liver transplantation at Albert Einstein Israeli Hospital between 2002-2007. A total of 596 liver transplants were performed in 540 patients. Overall, 77 fungal infections occurred in 68 (13%) patients. Among the 77 fungal infections, there were 40 IFI that occurred in 37 patients (7%). Candida and Aspergillus species were the most common etiologic agents. Candida species accounted for 82% of all fungal infections and for 67% of all IFI, while Aspergillus species accounted for 9% of all fungal infections and for 17% of all IFI. Non-albicans Candida species were the predominant Candida isolates. Invasive aspergillosis tended to occur earlier in the post-transplant period. These findings can contribute to improve antifungal prophylaxis and therapy practices in Brazilian centres. |
| first_indexed | 2024-03-12T18:18:00Z |
| format | Article |
| id | doaj.art-38e03be793894b8290cd3e4907e951f6 |
| institution | Directory Open Access Journal |
| issn | 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T18:18:00Z |
| publishDate | 2011-05-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-38e03be793894b8290cd3e4907e951f62023-08-02T09:00:14ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz1678-80602011-05-01106333934510.1590/S0074-02762011000300014S0074-02762011000300014Epidemiology of fungal infections in liver transplant recipients: a six-year study of a large Brazilian liver transplantation centreMichelle Zicker0Arnaldo Lopes Colombo1Ben-Hur Ferraz-Neto2Luis Fernando Aranha Camargo3Universidade Federal de São PauloUniversidade Federal de São PauloHospital Israelita Albert EinsteinUniversidade Federal de São PauloLiver transplant seems to be an effective option to prolong survival in patients with end-stage liver disease, although it still can be followed by serious complications. Invasive fungal infections (ifi) are related to high rates of morbidity and mortality. The epidemiology of fungal infections in Brazilian liver transplant recipients is unknown. The aim of this observational and retrospective study was to determine the incidence and epidemiology of fungal infections in all patients who underwent liver transplantation at Albert Einstein Israeli Hospital between 2002-2007. A total of 596 liver transplants were performed in 540 patients. Overall, 77 fungal infections occurred in 68 (13%) patients. Among the 77 fungal infections, there were 40 IFI that occurred in 37 patients (7%). Candida and Aspergillus species were the most common etiologic agents. Candida species accounted for 82% of all fungal infections and for 67% of all IFI, while Aspergillus species accounted for 9% of all fungal infections and for 17% of all IFI. Non-albicans Candida species were the predominant Candida isolates. Invasive aspergillosis tended to occur earlier in the post-transplant period. These findings can contribute to improve antifungal prophylaxis and therapy practices in Brazilian centres.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000300014&lng=en&tlng=enliver transplantationmycosesepidemiology |
| spellingShingle | Michelle Zicker Arnaldo Lopes Colombo Ben-Hur Ferraz-Neto Luis Fernando Aranha Camargo Epidemiology of fungal infections in liver transplant recipients: a six-year study of a large Brazilian liver transplantation centre Memorias do Instituto Oswaldo Cruz liver transplantation mycoses epidemiology |
| title | Epidemiology of fungal infections in liver transplant recipients: a six-year study of a large Brazilian liver transplantation centre |
| title_full | Epidemiology of fungal infections in liver transplant recipients: a six-year study of a large Brazilian liver transplantation centre |
| title_fullStr | Epidemiology of fungal infections in liver transplant recipients: a six-year study of a large Brazilian liver transplantation centre |
| title_full_unstemmed | Epidemiology of fungal infections in liver transplant recipients: a six-year study of a large Brazilian liver transplantation centre |
| title_short | Epidemiology of fungal infections in liver transplant recipients: a six-year study of a large Brazilian liver transplantation centre |
| title_sort | epidemiology of fungal infections in liver transplant recipients a six year study of a large brazilian liver transplantation centre |
| topic | liver transplantation mycoses epidemiology |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000300014&lng=en&tlng=en |
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