Post-translational modification patterns on β-myosin heavy chain are altered in ischemic and nonischemic human hearts

Post-translational modification patterns on β-myosin heavy chain are altered in ischemic and nonischemic human hearts

Phosphorylation and acetylation of sarcomeric proteins are important for fine-tuning myocardial contractility. Here, we used bottom-up proteomics and label-free quantification to identify novel post-translational modifications (PTMs) on β-myosin heavy chain (β-MHC) in normal and failing human heart...

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Bibliographic Details
Main Authors: Maicon Landim-Vieira, Matthew C Childers, Amanda L Wacker, Michelle Rodriquez Garcia, Huan He, Rakesh Singh, Elizabeth A Brundage, Jamie R Johnston, Bryan A Whitson, P Bryant Chase, Paul ML Janssen, Michael Regnier, Brandon J Biesiadecki, J Renato Pinto, Michelle S Parvatiyar
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-05-01
Series:eLife
Subjects:
myosin heavy chain
post-translational modifications
heart failure
human
Online Access:https://elifesciences.org/articles/74919

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