The Effects of Low Viscosity Preservative-Free Chloroprocaine Ophthalmic Gel 3% versus BAK-Containing Tetracaine 0.5% on the Bactericidal Action of Povidone-Iodine
Haroon Ilyas,1 Richard Costine2 1Brandon Eye Associates, Brandon, FL, 33511, USA; 2Harrow, Nashville, TN, 37205, USACorrespondence: Richard Costine, Harrow, Nashville, TN, 37205, USA, Email rcostine@harrowinc.comPurpose: To evaluate if chloroprocaine ophthalmic gel 3% acts as a barrier to the bacter...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2024-03-01
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| Series: | Clinical Ophthalmology |
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| Online Access: | https://www.dovepress.com/the-effects-of-low-viscosity-preservative-free-chloroprocaine-ophthalm-peer-reviewed-fulltext-article-OPTH |
| _version_ | 1797262166398599168 |
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| author | Ilyas H Costine R |
| author_facet | Ilyas H Costine R |
| author_sort | Ilyas H |
| collection | DOAJ |
| description | Haroon Ilyas,1 Richard Costine2 1Brandon Eye Associates, Brandon, FL, 33511, USA; 2Harrow, Nashville, TN, 37205, USACorrespondence: Richard Costine, Harrow, Nashville, TN, 37205, USA, Email rcostine@harrowinc.comPurpose: To evaluate if chloroprocaine ophthalmic gel 3% acts as a barrier to the bactericidal actions of povidone-iodine (PVI) which has been seen in other higher viscosity gel anesthetics.Methods: This was a single site, prospective, randomized, patient-masked study evaluating the effects of preservative-free chloroprocaine ophthalmic gel 3% (IHEEZO®, Harrow, Nashville, TN) compared with tetracaine ophthalmic solution 0.5% and their effects on the bactericidal action of povidone-iodine 5%. The study comprised 82 patients who had both eyes cultured before and after application of randomized treatment and povidone-iodine.Results: In terms of mean percent reduction in colony forming units, chloroprocaine with povidone-iodine was non-inferior to tetracaine with povidone-iodine, with a higher mean percent reduction in colony forming units in the chloroprocaine group (change [∆] = − 7.2; 90% CI, − 13.56 to 3.28).Conclusion: Data collected in this study suggest that preservative-free chloroprocaine ophthalmic gel 3% does not act as a barrier to the bactericidal actions of povidone-iodine 5% and that the reduction in CFU from PVI is similar when compared with tetracaine 0.5% ophthalmic solution with PVI.Keywords: anesthetics, cataract, cornea, infection, drug formulation |
| first_indexed | 2024-04-24T23:52:47Z |
| format | Article |
| id | doaj.art-38e47cec761a4213bd859cc487056651 |
| institution | Directory Open Access Journal |
| issn | 1177-5483 |
| language | English |
| last_indexed | 2024-04-24T23:52:47Z |
| publishDate | 2024-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Ophthalmology |
| spelling | doaj.art-38e47cec761a4213bd859cc4870566512024-03-14T17:13:26ZengDove Medical PressClinical Ophthalmology1177-54832024-03-01Volume 1882583191217The Effects of Low Viscosity Preservative-Free Chloroprocaine Ophthalmic Gel 3% versus BAK-Containing Tetracaine 0.5% on the Bactericidal Action of Povidone-IodineIlyas HCostine RHaroon Ilyas,1 Richard Costine2 1Brandon Eye Associates, Brandon, FL, 33511, USA; 2Harrow, Nashville, TN, 37205, USACorrespondence: Richard Costine, Harrow, Nashville, TN, 37205, USA, Email rcostine@harrowinc.comPurpose: To evaluate if chloroprocaine ophthalmic gel 3% acts as a barrier to the bactericidal actions of povidone-iodine (PVI) which has been seen in other higher viscosity gel anesthetics.Methods: This was a single site, prospective, randomized, patient-masked study evaluating the effects of preservative-free chloroprocaine ophthalmic gel 3% (IHEEZO®, Harrow, Nashville, TN) compared with tetracaine ophthalmic solution 0.5% and their effects on the bactericidal action of povidone-iodine 5%. The study comprised 82 patients who had both eyes cultured before and after application of randomized treatment and povidone-iodine.Results: In terms of mean percent reduction in colony forming units, chloroprocaine with povidone-iodine was non-inferior to tetracaine with povidone-iodine, with a higher mean percent reduction in colony forming units in the chloroprocaine group (change [∆] = − 7.2; 90% CI, − 13.56 to 3.28).Conclusion: Data collected in this study suggest that preservative-free chloroprocaine ophthalmic gel 3% does not act as a barrier to the bactericidal actions of povidone-iodine 5% and that the reduction in CFU from PVI is similar when compared with tetracaine 0.5% ophthalmic solution with PVI.Keywords: anesthetics, cataract, cornea, infection, drug formulationhttps://www.dovepress.com/the-effects-of-low-viscosity-preservative-free-chloroprocaine-ophthalm-peer-reviewed-fulltext-article-OPTHanestheticscataractcorneainfectiondrug formulation |
| spellingShingle | Ilyas H Costine R The Effects of Low Viscosity Preservative-Free Chloroprocaine Ophthalmic Gel 3% versus BAK-Containing Tetracaine 0.5% on the Bactericidal Action of Povidone-Iodine Clinical Ophthalmology anesthetics cataract cornea infection drug formulation |
| title | The Effects of Low Viscosity Preservative-Free Chloroprocaine Ophthalmic Gel 3% versus BAK-Containing Tetracaine 0.5% on the Bactericidal Action of Povidone-Iodine |
| title_full | The Effects of Low Viscosity Preservative-Free Chloroprocaine Ophthalmic Gel 3% versus BAK-Containing Tetracaine 0.5% on the Bactericidal Action of Povidone-Iodine |
| title_fullStr | The Effects of Low Viscosity Preservative-Free Chloroprocaine Ophthalmic Gel 3% versus BAK-Containing Tetracaine 0.5% on the Bactericidal Action of Povidone-Iodine |
| title_full_unstemmed | The Effects of Low Viscosity Preservative-Free Chloroprocaine Ophthalmic Gel 3% versus BAK-Containing Tetracaine 0.5% on the Bactericidal Action of Povidone-Iodine |
| title_short | The Effects of Low Viscosity Preservative-Free Chloroprocaine Ophthalmic Gel 3% versus BAK-Containing Tetracaine 0.5% on the Bactericidal Action of Povidone-Iodine |
| title_sort | effects of low viscosity preservative free chloroprocaine ophthalmic gel 3 versus bak containing tetracaine 0 5 on the bactericidal action of povidone iodine |
| topic | anesthetics cataract cornea infection drug formulation |
| url | https://www.dovepress.com/the-effects-of-low-viscosity-preservative-free-chloroprocaine-ophthalm-peer-reviewed-fulltext-article-OPTH |
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