Some pathogenetic aspects of experimental pneumococcal meningitis in acute period
Morphological displays of cerebral microcirculation derangements in a brain cortex with their semiquantitative estimation have been studied in experimental mice model of the first 24-72 hours period of pneumococcal meningitis.Also displays oxidative stress and activity antioxidative protectional sys...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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Journal Infectology
2014-09-01
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| Series: | Журнал инфектологии |
| Subjects: | |
| Online Access: | https://journal.niidi.ru/jofin/article/view/19 |
| _version_ | 1797702620962357248 |
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| author | V. V. Pilipenko Yu. V. Lobzin V. L. Pastushenkov V. E. Karev M. O. Volkova |
| author_facet | V. V. Pilipenko Yu. V. Lobzin V. L. Pastushenkov V. E. Karev M. O. Volkova |
| author_sort | V. V. Pilipenko |
| collection | DOAJ |
| description | Morphological displays of cerebral microcirculation derangements in a brain cortex with their semiquantitative estimation have been studied in experimental mice model of the first 24-72 hours period of pneumococcal meningitis.Also displays oxidative stress and activity antioxidative protectional system by means of definition of markers of these processes – malondialdehide, reduced glutathione and glucose-6-phosphate-dehydrogenase activity have been investigated. The received results testify to morphological signs of the expressed derangements of cerebral microcirculation in a brain cortex already by first 24 hour of an experimental meningitis. The maximum expressiveness oxidative stress and activity antioxidative protectional system of reduced glutathione with the max activity of glucose-6-phosphatedehydrogenase in a mice brain cortex was noted at first 48hour durations of experimental disease. Signs of irreversible changes of mice cortex neurons are not revealed at 24–72-hour duration of experimental pneumococcal meningitis. |
| first_indexed | 2024-03-12T04:52:42Z |
| format | Article |
| id | doaj.art-38e5332275c64ce4837d13d751dede64 |
| institution | Directory Open Access Journal |
| issn | 2072-6732 |
| language | Russian |
| last_indexed | 2024-03-12T04:52:42Z |
| publishDate | 2014-09-01 |
| publisher | Journal Infectology |
| record_format | Article |
| series | Журнал инфектологии |
| spelling | doaj.art-38e5332275c64ce4837d13d751dede642023-09-03T09:18:13ZrusJournal InfectologyЖурнал инфектологии2072-67322014-09-0132333910.22625/2072-6732-2011-3-2-33-3933Some pathogenetic aspects of experimental pneumococcal meningitis in acute periodV. V. Pilipenko0Yu. V. Lobzin1V. L. Pastushenkov2V. E. Karev3M. O. Volkova4Санкт-Петербургская медицинская академия последипломного образования, Санкт-ПетербургНаучно-исследовательский институт детских инфекций ФМБА России, Санкт-ПетербургАссоциация независимых клинико-диагностических лабораторий Ситилаб, МоскваНаучно-исследовательский институт детских инфекций ФМБА России, Санкт-ПетербургНаучно-исследовательский институт детских инфекций ФМБА России, Санкт-ПетербургMorphological displays of cerebral microcirculation derangements in a brain cortex with their semiquantitative estimation have been studied in experimental mice model of the first 24-72 hours period of pneumococcal meningitis.Also displays oxidative stress and activity antioxidative protectional system by means of definition of markers of these processes – malondialdehide, reduced glutathione and glucose-6-phosphate-dehydrogenase activity have been investigated. The received results testify to morphological signs of the expressed derangements of cerebral microcirculation in a brain cortex already by first 24 hour of an experimental meningitis. The maximum expressiveness oxidative stress and activity antioxidative protectional system of reduced glutathione with the max activity of glucose-6-phosphatedehydrogenase in a mice brain cortex was noted at first 48hour durations of experimental disease. Signs of irreversible changes of mice cortex neurons are not revealed at 24–72-hour duration of experimental pneumococcal meningitis.https://journal.niidi.ru/jofin/article/view/19пневмококковый менингитэкспериментальная моделькора головного мозгацеребральные микроваскулярные нарушениямалоновый диальдегидвосстановленный глутатион |
| spellingShingle | V. V. Pilipenko Yu. V. Lobzin V. L. Pastushenkov V. E. Karev M. O. Volkova Some pathogenetic aspects of experimental pneumococcal meningitis in acute period Журнал инфектологии пневмококковый менингит экспериментальная модель кора головного мозга церебральные микроваскулярные нарушения малоновый диальдегид восстановленный глутатион |
| title | Some pathogenetic aspects of experimental pneumococcal meningitis in acute period |
| title_full | Some pathogenetic aspects of experimental pneumococcal meningitis in acute period |
| title_fullStr | Some pathogenetic aspects of experimental pneumococcal meningitis in acute period |
| title_full_unstemmed | Some pathogenetic aspects of experimental pneumococcal meningitis in acute period |
| title_short | Some pathogenetic aspects of experimental pneumococcal meningitis in acute period |
| title_sort | some pathogenetic aspects of experimental pneumococcal meningitis in acute period |
| topic | пневмококковый менингит экспериментальная модель кора головного мозга церебральные микроваскулярные нарушения малоновый диальдегид восстановленный глутатион |
| url | https://journal.niidi.ru/jofin/article/view/19 |
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