In Vitro Estimation of Relative Compliance during High-Frequency Oscillatory Ventilation
High-frequency oscillatory ventilation (HFOV), which uses a small tidal volume and a high respiratory rate, is considered a type of protective lung ventilation that can be beneficial for certain patients. A disadvantage of HFOV is its limited monitoring of lung mechanics, which complicates its setti...
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MDPI AG
2021-01-01
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| Online Access: | https://www.mdpi.com/2076-3417/11/3/899 |
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| author | Jan Matejka Martin Rozanek Jakub Rafl Petr Kudrna Karel Roubik |
| author_facet | Jan Matejka Martin Rozanek Jakub Rafl Petr Kudrna Karel Roubik |
| author_sort | Jan Matejka |
| collection | DOAJ |
| description | High-frequency oscillatory ventilation (HFOV), which uses a small tidal volume and a high respiratory rate, is considered a type of protective lung ventilation that can be beneficial for certain patients. A disadvantage of HFOV is its limited monitoring of lung mechanics, which complicates its settings and optimal adjustment. Recent studies have shown that respiratory system reactance (<i>X</i><sub>rs</sub>) could be a promising parameter in the evaluation of respiratory system mechanics in HFOV. The aim of this study was to verify in vitro that a change in respiratory system mechanics during HFOV can be monitored by evaluating <i>X</i><sub>rs</sub>. We built an experimental system consisting of a 3100B high-frequency oscillatory ventilator, a physical model of the respiratory system with constant compliance, and a system for pressure and flow measurements. During the experiment, models of different constant compliance were connected to HFOV, and <i>X</i><sub>rs</sub> was derived from the impedance of the physical model that was calculated from the spectral density of airway opening pressure and spectral cross-power density of gas flow and airway opening pressure. The calculated <i>X</i><sub>rs</sub> changed with the change of compliance of the physical model of the respiratory system. This method enabled monitoring of the trend in the respiratory system compliance during HFOV, and has the potential to optimize the mean pressure setting in HFOV in clinical practice. |
| first_indexed | 2024-03-09T04:15:44Z |
| format | Article |
| id | doaj.art-38e5fab874ab44fa9973ecbbc8e5649a |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-09T04:15:44Z |
| publishDate | 2021-01-01 |
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| spelling | doaj.art-38e5fab874ab44fa9973ecbbc8e5649a2023-12-03T13:54:30ZengMDPI AGApplied Sciences2076-34172021-01-0111389910.3390/app11030899In Vitro Estimation of Relative Compliance during High-Frequency Oscillatory VentilationJan Matejka0Martin Rozanek1Jakub Rafl2Petr Kudrna3Karel Roubik4Department of Biomedical Technology, Faculty of Biomedical Engineering, Czech Technical University in Prague, nam. Sitna 3105, CZ-272 01 Kladno, Czech RepublicDepartment of Biomedical Technology, Faculty of Biomedical Engineering, Czech Technical University in Prague, nam. Sitna 3105, CZ-272 01 Kladno, Czech RepublicDepartment of Biomedical Technology, Faculty of Biomedical Engineering, Czech Technical University in Prague, nam. Sitna 3105, CZ-272 01 Kladno, Czech RepublicDepartment of Biomedical Technology, Faculty of Biomedical Engineering, Czech Technical University in Prague, nam. Sitna 3105, CZ-272 01 Kladno, Czech RepublicDepartment of Biomedical Technology, Faculty of Biomedical Engineering, Czech Technical University in Prague, nam. Sitna 3105, CZ-272 01 Kladno, Czech RepublicHigh-frequency oscillatory ventilation (HFOV), which uses a small tidal volume and a high respiratory rate, is considered a type of protective lung ventilation that can be beneficial for certain patients. A disadvantage of HFOV is its limited monitoring of lung mechanics, which complicates its settings and optimal adjustment. Recent studies have shown that respiratory system reactance (<i>X</i><sub>rs</sub>) could be a promising parameter in the evaluation of respiratory system mechanics in HFOV. The aim of this study was to verify in vitro that a change in respiratory system mechanics during HFOV can be monitored by evaluating <i>X</i><sub>rs</sub>. We built an experimental system consisting of a 3100B high-frequency oscillatory ventilator, a physical model of the respiratory system with constant compliance, and a system for pressure and flow measurements. During the experiment, models of different constant compliance were connected to HFOV, and <i>X</i><sub>rs</sub> was derived from the impedance of the physical model that was calculated from the spectral density of airway opening pressure and spectral cross-power density of gas flow and airway opening pressure. The calculated <i>X</i><sub>rs</sub> changed with the change of compliance of the physical model of the respiratory system. This method enabled monitoring of the trend in the respiratory system compliance during HFOV, and has the potential to optimize the mean pressure setting in HFOV in clinical practice.https://www.mdpi.com/2076-3417/11/3/899high-frequency oscillatory ventilationcontinuous distending pressurelung compliancerespiratory system reactancerigid respiratory system model |
| spellingShingle | Jan Matejka Martin Rozanek Jakub Rafl Petr Kudrna Karel Roubik In Vitro Estimation of Relative Compliance during High-Frequency Oscillatory Ventilation Applied Sciences high-frequency oscillatory ventilation continuous distending pressure lung compliance respiratory system reactance rigid respiratory system model |
| title | In Vitro Estimation of Relative Compliance during High-Frequency Oscillatory Ventilation |
| title_full | In Vitro Estimation of Relative Compliance during High-Frequency Oscillatory Ventilation |
| title_fullStr | In Vitro Estimation of Relative Compliance during High-Frequency Oscillatory Ventilation |
| title_full_unstemmed | In Vitro Estimation of Relative Compliance during High-Frequency Oscillatory Ventilation |
| title_short | In Vitro Estimation of Relative Compliance during High-Frequency Oscillatory Ventilation |
| title_sort | in vitro estimation of relative compliance during high frequency oscillatory ventilation |
| topic | high-frequency oscillatory ventilation continuous distending pressure lung compliance respiratory system reactance rigid respiratory system model |
| url | https://www.mdpi.com/2076-3417/11/3/899 |
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