Clinical features and outcomes of nontransitional cell carcinomas of the urinary bladder: Analysis of 125 cases
Objectives: The aim was to evaluate pathologic diagnosis, treatment and prognosis of 125 patients with nontransitional cell carcinoma of the urinary bladder. Materials and Methods: A total of 3590 patients with bladder tumors operated in our clinic between September 1998 and May 2013 were retrospec...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-01-01
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| Series: | Urology Annals |
| Subjects: | |
| Online Access: | http://www.urologyannals.com/article.asp?issn=0974-7796;year=2015;volume=7;issue=2;spage=177;epage=182;aulast=Arslan |
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| author | Burak Arslan Ibrahim Halil Bozkurt Tarik Yonguc Enver Vardar Tansu Degirmenci Zafer Kozacioglu Bulent Gunlusoy Suleyman Minareci |
| author_facet | Burak Arslan Ibrahim Halil Bozkurt Tarik Yonguc Enver Vardar Tansu Degirmenci Zafer Kozacioglu Bulent Gunlusoy Suleyman Minareci |
| author_sort | Burak Arslan |
| collection | DOAJ |
| description | Objectives: The aim was to evaluate pathologic diagnosis, treatment and prognosis of 125 patients with nontransitional cell carcinoma of the urinary bladder.
Materials and Methods: A total of 3590 patients with bladder tumors operated in our clinic between September 1998 and May 2013 were retrospectively evaluated. A total of 125 patients (107 men and 18 women) with nontransitional cell bladder cancer, confirmed by histopathology, were included in this study. The patients′ characteristics, including age, gender, smoking history, tumor size, and localization, histological types, pathological tumor stages, treatment modalities, and survival rates were all recorded.
Results: Of these tumors, 47 (37.6%) were adenocarcinoma (AC), 42 (33.6%) were squamous cell carcinoma (SCC), 23 (18.4%) were undifferentiated carcinoma (UC), 13 (10.4%) were other types of bladder carcinoma. Sixty-three (50.4%) patients had undergone radical cystectomy and pelvic lymphadenectomy ± adjuvant treatment (chemotherapy [CT]/radiotherapy) and 52 (41.6%) patients received radiotherapy ± CT. The median survival time of patients with AC and SCC were significantly higher than patients with UC (AC vs UC, P = 0.001; SCC vs UC, P = 0.000; AC vs. SCC, P = 0.219). Median survival time was significantly higher in radical cystectomy ± adjuvant treatment group (P < 0.05) in all histological types.
Conclusion: Prognosis of urinary bladder tumors was directly related to histological type and stage of the tumor. CT or radiotherapy has limited response rates. Early radical cystectomy should be performed to improve prognosis. |
| first_indexed | 2024-12-20T17:23:08Z |
| format | Article |
| id | doaj.art-38e6f151116b487491d755769179e3ed |
| institution | Directory Open Access Journal |
| issn | 0974-7796 0974-7834 |
| language | English |
| last_indexed | 2024-12-20T17:23:08Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Urology Annals |
| spelling | doaj.art-38e6f151116b487491d755769179e3ed2022-12-21T19:31:41ZengWolters Kluwer Medknow PublicationsUrology Annals0974-77960974-78342015-01-017217718210.4103/0974-7796.150533Clinical features and outcomes of nontransitional cell carcinomas of the urinary bladder: Analysis of 125 casesBurak ArslanIbrahim Halil BozkurtTarik YongucEnver VardarTansu DegirmenciZafer KozaciogluBulent GunlusoySuleyman MinareciObjectives: The aim was to evaluate pathologic diagnosis, treatment and prognosis of 125 patients with nontransitional cell carcinoma of the urinary bladder. Materials and Methods: A total of 3590 patients with bladder tumors operated in our clinic between September 1998 and May 2013 were retrospectively evaluated. A total of 125 patients (107 men and 18 women) with nontransitional cell bladder cancer, confirmed by histopathology, were included in this study. The patients′ characteristics, including age, gender, smoking history, tumor size, and localization, histological types, pathological tumor stages, treatment modalities, and survival rates were all recorded. Results: Of these tumors, 47 (37.6%) were adenocarcinoma (AC), 42 (33.6%) were squamous cell carcinoma (SCC), 23 (18.4%) were undifferentiated carcinoma (UC), 13 (10.4%) were other types of bladder carcinoma. Sixty-three (50.4%) patients had undergone radical cystectomy and pelvic lymphadenectomy ± adjuvant treatment (chemotherapy [CT]/radiotherapy) and 52 (41.6%) patients received radiotherapy ± CT. The median survival time of patients with AC and SCC were significantly higher than patients with UC (AC vs UC, P = 0.001; SCC vs UC, P = 0.000; AC vs. SCC, P = 0.219). Median survival time was significantly higher in radical cystectomy ± adjuvant treatment group (P < 0.05) in all histological types. Conclusion: Prognosis of urinary bladder tumors was directly related to histological type and stage of the tumor. CT or radiotherapy has limited response rates. Early radical cystectomy should be performed to improve prognosis.http://www.urologyannals.com/article.asp?issn=0974-7796;year=2015;volume=7;issue=2;spage=177;epage=182;aulast=ArslanAdenocarcinomacystectomysquamous cell carcinoma |
| spellingShingle | Burak Arslan Ibrahim Halil Bozkurt Tarik Yonguc Enver Vardar Tansu Degirmenci Zafer Kozacioglu Bulent Gunlusoy Suleyman Minareci Clinical features and outcomes of nontransitional cell carcinomas of the urinary bladder: Analysis of 125 cases Urology Annals Adenocarcinoma cystectomy squamous cell carcinoma |
| title | Clinical features and outcomes of nontransitional cell carcinomas of the urinary bladder: Analysis of 125 cases |
| title_full | Clinical features and outcomes of nontransitional cell carcinomas of the urinary bladder: Analysis of 125 cases |
| title_fullStr | Clinical features and outcomes of nontransitional cell carcinomas of the urinary bladder: Analysis of 125 cases |
| title_full_unstemmed | Clinical features and outcomes of nontransitional cell carcinomas of the urinary bladder: Analysis of 125 cases |
| title_short | Clinical features and outcomes of nontransitional cell carcinomas of the urinary bladder: Analysis of 125 cases |
| title_sort | clinical features and outcomes of nontransitional cell carcinomas of the urinary bladder analysis of 125 cases |
| topic | Adenocarcinoma cystectomy squamous cell carcinoma |
| url | http://www.urologyannals.com/article.asp?issn=0974-7796;year=2015;volume=7;issue=2;spage=177;epage=182;aulast=Arslan |
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