DNA display of glycoconjugates to emulate oligomeric interactions of glycans
Glycans (carbohydrate portion of glycoproteins and glycolipids) frequently exert their function through oligomeric interactions involving multiple carbohydrate units. In efforts to recapitulate the diverse spatial arrangements of the carbohydrate units, assemblies based on hybridization of nucleic a...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Beilstein-Institut
2015-05-01
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| Series: | Beilstein Journal of Organic Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.3762/bjoc.11.81 |
| _version_ | 1818733392968024064 |
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| author | Alexandre Novoa Nicolas Winssinger |
| author_facet | Alexandre Novoa Nicolas Winssinger |
| author_sort | Alexandre Novoa |
| collection | DOAJ |
| description | Glycans (carbohydrate portion of glycoproteins and glycolipids) frequently exert their function through oligomeric interactions involving multiple carbohydrate units. In efforts to recapitulate the diverse spatial arrangements of the carbohydrate units, assemblies based on hybridization of nucleic acid conjugates have been used to display simplified ligands with tailored interligand distances and valences. The programmability of the assemblies lends itself to a combinatorial display of multiple ligands. Recent efforts in the synthesis and applications of such conjugates are discussed. |
| first_indexed | 2024-12-17T23:48:45Z |
| format | Article |
| id | doaj.art-38e8060034dd4703b21863f31eb32d91 |
| institution | Directory Open Access Journal |
| issn | 1860-5397 |
| language | English |
| last_indexed | 2024-12-17T23:48:45Z |
| publishDate | 2015-05-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Organic Chemistry |
| spelling | doaj.art-38e8060034dd4703b21863f31eb32d912022-12-21T21:28:14ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972015-05-0111170771910.3762/bjoc.11.811860-5397-11-81DNA display of glycoconjugates to emulate oligomeric interactions of glycansAlexandre Novoa0Nicolas Winssinger1Department of Organic Chemistry, NCCR Chemical Biology, University of Geneva 30, quai Ernest Ansermet, 1211 Geneva, SwitzerlandDepartment of Organic Chemistry, NCCR Chemical Biology, University of Geneva 30, quai Ernest Ansermet, 1211 Geneva, SwitzerlandGlycans (carbohydrate portion of glycoproteins and glycolipids) frequently exert their function through oligomeric interactions involving multiple carbohydrate units. In efforts to recapitulate the diverse spatial arrangements of the carbohydrate units, assemblies based on hybridization of nucleic acid conjugates have been used to display simplified ligands with tailored interligand distances and valences. The programmability of the assemblies lends itself to a combinatorial display of multiple ligands. Recent efforts in the synthesis and applications of such conjugates are discussed.https://doi.org/10.3762/bjoc.11.81glycanglycoconjugateDNA displaymultivalencynucleic acid conjugatesoligomeric interaction |
| spellingShingle | Alexandre Novoa Nicolas Winssinger DNA display of glycoconjugates to emulate oligomeric interactions of glycans Beilstein Journal of Organic Chemistry glycan glycoconjugate DNA display multivalency nucleic acid conjugates oligomeric interaction |
| title | DNA display of glycoconjugates to emulate oligomeric interactions of glycans |
| title_full | DNA display of glycoconjugates to emulate oligomeric interactions of glycans |
| title_fullStr | DNA display of glycoconjugates to emulate oligomeric interactions of glycans |
| title_full_unstemmed | DNA display of glycoconjugates to emulate oligomeric interactions of glycans |
| title_short | DNA display of glycoconjugates to emulate oligomeric interactions of glycans |
| title_sort | dna display of glycoconjugates to emulate oligomeric interactions of glycans |
| topic | glycan glycoconjugate DNA display multivalency nucleic acid conjugates oligomeric interaction |
| url | https://doi.org/10.3762/bjoc.11.81 |
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