Complexation and sequestration of BMP-2 from an ECM mimetic hyaluronan gel for improved bone formation.

Complexation and sequestration of BMP-2 from an ECM mimetic hyaluronan gel for improved bone formation.

Bone morphogenetic protein-2 (BMP-2) is considered a promising adjuvant for the treatment of skeletal non-union and spinal fusion. However, BMP-2 delivery in a conventional collagen scaffold necessitates a high dose to achieve an efficacious outcome. To lower its effective dose, we precomplexed BMP-...

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Bibliographic Details
Main Authors: Marta Kisiel, Agnieszka S Klar, Manuela Ventura, Jos Buijs, Marc-Krystelle Mafina, Simon M Cool, Jöns Hilborn
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3805527?pdf=render

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