Application and underlying mechanism of acupuncture for the nerve repair after peripheral nerve injury: remodeling of nerve system
Peripheral nerve injury (PNI) is a structural event with harmful consequences worldwide. Due to the limited intrinsic regenerative capacity of the peripheral nerve in adults, neural restoration after PNI is difficult. Neurological remodeling has a crucial effect on the repair of the form and functio...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-10-01
|
| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2023.1253438/full |
| _version_ | 1827784640964853760 |
|---|---|
| author | Yongke Yang Chang Rao Tianlong Yin Shaokang Wang Huiyan Shi Huiyan Shi Xin Yan Lili Zhang Xianggang Meng Wenlong Gu Yuzheng Du Feng Hong |
| author_facet | Yongke Yang Chang Rao Tianlong Yin Shaokang Wang Huiyan Shi Huiyan Shi Xin Yan Lili Zhang Xianggang Meng Wenlong Gu Yuzheng Du Feng Hong |
| author_sort | Yongke Yang |
| collection | DOAJ |
| description | Peripheral nerve injury (PNI) is a structural event with harmful consequences worldwide. Due to the limited intrinsic regenerative capacity of the peripheral nerve in adults, neural restoration after PNI is difficult. Neurological remodeling has a crucial effect on the repair of the form and function during the regeneration of the peripheral nerve after the peripheral nerve is injured. Several studies have demonstrated that acupuncture is effective for PNI-induced neurologic deficits, and the potential mechanisms responsible for its effects involve the nervous system remodeling in the process of nerve repair. Moreover, acupuncture promotes neural regeneration and axon sprouting by activating related neurotrophins retrograde transport, such as nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell-derived neurotrophic factor (GDNF), N-cadherin, and MicroRNAs. Peripheral nerve injury enhances the perceptual response of the central nervous system to pain, causing central sensitization and accelerating neuronal cell apoptosis. Together with this, the remodeling of synaptic transmission function would worsen pain discomfort. Neuroimaging studies have shown remodeling changes in both gray and white matter after peripheral nerve injury. Acupuncture not only reverses the poor remodeling of the nervous system but also stimulates the release of neurotrophic substances such as nerve growth factors in the nervous system to ameliorate pain and promote the regeneration and repair of nerve fibers. In conclusion, the neurological remodeling at the peripheral and central levels in the process of acupuncture treatment accelerates nerve regeneration and repair. These findings provide novel insights enabling the clinical application of acupuncture in the treatment of PNI. |
| first_indexed | 2024-03-11T16:07:03Z |
| format | Article |
| id | doaj.art-38eac22ad94b4825b410bb0656cf6f46 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-03-11T16:07:03Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-38eac22ad94b4825b410bb0656cf6f462023-10-24T21:27:38ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022023-10-011710.3389/fncel.2023.12534381253438Application and underlying mechanism of acupuncture for the nerve repair after peripheral nerve injury: remodeling of nerve systemYongke Yang0Chang Rao1Tianlong Yin2Shaokang Wang3Huiyan Shi4Huiyan Shi5Xin Yan6Lili Zhang7Xianggang Meng8Wenlong Gu9Yuzheng Du10Feng Hong11Beilun District People’s Hospital, Ningbo, ChinaTianjin Union Medical Center, Tianjin, ChinaFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaNational Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, ChinaNational Anti-Drug Laboratory Beijing Regional Center, Beijing, ChinaFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaBeilun District People’s Hospital, Ningbo, ChinaPeripheral nerve injury (PNI) is a structural event with harmful consequences worldwide. Due to the limited intrinsic regenerative capacity of the peripheral nerve in adults, neural restoration after PNI is difficult. Neurological remodeling has a crucial effect on the repair of the form and function during the regeneration of the peripheral nerve after the peripheral nerve is injured. Several studies have demonstrated that acupuncture is effective for PNI-induced neurologic deficits, and the potential mechanisms responsible for its effects involve the nervous system remodeling in the process of nerve repair. Moreover, acupuncture promotes neural regeneration and axon sprouting by activating related neurotrophins retrograde transport, such as nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell-derived neurotrophic factor (GDNF), N-cadherin, and MicroRNAs. Peripheral nerve injury enhances the perceptual response of the central nervous system to pain, causing central sensitization and accelerating neuronal cell apoptosis. Together with this, the remodeling of synaptic transmission function would worsen pain discomfort. Neuroimaging studies have shown remodeling changes in both gray and white matter after peripheral nerve injury. Acupuncture not only reverses the poor remodeling of the nervous system but also stimulates the release of neurotrophic substances such as nerve growth factors in the nervous system to ameliorate pain and promote the regeneration and repair of nerve fibers. In conclusion, the neurological remodeling at the peripheral and central levels in the process of acupuncture treatment accelerates nerve regeneration and repair. These findings provide novel insights enabling the clinical application of acupuncture in the treatment of PNI.https://www.frontiersin.org/articles/10.3389/fncel.2023.1253438/fullacupunctureperipheral nerve injurymechanismnerve system remodelingnerve repair |
| spellingShingle | Yongke Yang Chang Rao Tianlong Yin Shaokang Wang Huiyan Shi Huiyan Shi Xin Yan Lili Zhang Xianggang Meng Wenlong Gu Yuzheng Du Feng Hong Application and underlying mechanism of acupuncture for the nerve repair after peripheral nerve injury: remodeling of nerve system Frontiers in Cellular Neuroscience acupuncture peripheral nerve injury mechanism nerve system remodeling nerve repair |
| title | Application and underlying mechanism of acupuncture for the nerve repair after peripheral nerve injury: remodeling of nerve system |
| title_full | Application and underlying mechanism of acupuncture for the nerve repair after peripheral nerve injury: remodeling of nerve system |
| title_fullStr | Application and underlying mechanism of acupuncture for the nerve repair after peripheral nerve injury: remodeling of nerve system |
| title_full_unstemmed | Application and underlying mechanism of acupuncture for the nerve repair after peripheral nerve injury: remodeling of nerve system |
| title_short | Application and underlying mechanism of acupuncture for the nerve repair after peripheral nerve injury: remodeling of nerve system |
| title_sort | application and underlying mechanism of acupuncture for the nerve repair after peripheral nerve injury remodeling of nerve system |
| topic | acupuncture peripheral nerve injury mechanism nerve system remodeling nerve repair |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2023.1253438/full |
| work_keys_str_mv | AT yongkeyang applicationandunderlyingmechanismofacupunctureforthenerverepairafterperipheralnerveinjuryremodelingofnervesystem AT changrao applicationandunderlyingmechanismofacupunctureforthenerverepairafterperipheralnerveinjuryremodelingofnervesystem AT tianlongyin applicationandunderlyingmechanismofacupunctureforthenerverepairafterperipheralnerveinjuryremodelingofnervesystem AT shaokangwang applicationandunderlyingmechanismofacupunctureforthenerverepairafterperipheralnerveinjuryremodelingofnervesystem AT huiyanshi applicationandunderlyingmechanismofacupunctureforthenerverepairafterperipheralnerveinjuryremodelingofnervesystem AT huiyanshi applicationandunderlyingmechanismofacupunctureforthenerverepairafterperipheralnerveinjuryremodelingofnervesystem AT xinyan applicationandunderlyingmechanismofacupunctureforthenerverepairafterperipheralnerveinjuryremodelingofnervesystem AT lilizhang applicationandunderlyingmechanismofacupunctureforthenerverepairafterperipheralnerveinjuryremodelingofnervesystem AT xianggangmeng applicationandunderlyingmechanismofacupunctureforthenerverepairafterperipheralnerveinjuryremodelingofnervesystem AT wenlonggu applicationandunderlyingmechanismofacupunctureforthenerverepairafterperipheralnerveinjuryremodelingofnervesystem AT yuzhengdu applicationandunderlyingmechanismofacupunctureforthenerverepairafterperipheralnerveinjuryremodelingofnervesystem AT fenghong applicationandunderlyingmechanismofacupunctureforthenerverepairafterperipheralnerveinjuryremodelingofnervesystem |