Role of neuroactive steroids in the peripheral nervous system
Several reviews have so far pointed out on the relevant physiological and pharmacological role exerted by neuroactive steroids in the central nervous system. In the present review we summarize observations indicating that synthesis and metabolism of neuroactive steroids also occur in the peripheral...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2011-12-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fendo.2011.00104/full |
| _version_ | 1811242493869555712 |
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| author | Roberto Cosimo eMelcangi Silvia eGiatti Marzia ePesaresi Donato eCarabrese Nico eMitro Donatella eCaruso Luis Miguel Garcia-Segura |
| author_facet | Roberto Cosimo eMelcangi Silvia eGiatti Marzia ePesaresi Donato eCarabrese Nico eMitro Donatella eCaruso Luis Miguel Garcia-Segura |
| author_sort | Roberto Cosimo eMelcangi |
| collection | DOAJ |
| description | Several reviews have so far pointed out on the relevant physiological and pharmacological role exerted by neuroactive steroids in the central nervous system. In the present review we summarize observations indicating that synthesis and metabolism of neuroactive steroids also occur in the peripheral nerves. Interestingly, peripheral nervous system is also a target of their action. Indeed, as here reported neuroactive steroids are physiological regulators of peripheral nerve functions and they may also represent interesting therapeutic tools for different types of peripheral neuropathy. |
| first_indexed | 2024-04-12T13:51:58Z |
| format | Article |
| id | doaj.art-38eadb9ea6374c63bade31a43ac92d44 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-12T13:51:58Z |
| publishDate | 2011-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-38eadb9ea6374c63bade31a43ac92d442022-12-22T03:30:30ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922011-12-01210.3389/fendo.2011.0010412840Role of neuroactive steroids in the peripheral nervous systemRoberto Cosimo eMelcangi0Silvia eGiatti1Marzia ePesaresi2Donato eCarabrese3Nico eMitro4Donatella eCaruso5Luis Miguel Garcia-Segura6Università degli Studi di MIlanoUniversità degli Studi di MIlanoUniversità degli Studi di MIlanoUniversità degli Studi di MIlanoUniversità degli studi di MilanoUniversità degli studi di MilanoInstituto Cajal, C.S.I.C.Several reviews have so far pointed out on the relevant physiological and pharmacological role exerted by neuroactive steroids in the central nervous system. In the present review we summarize observations indicating that synthesis and metabolism of neuroactive steroids also occur in the peripheral nerves. Interestingly, peripheral nervous system is also a target of their action. Indeed, as here reported neuroactive steroids are physiological regulators of peripheral nerve functions and they may also represent interesting therapeutic tools for different types of peripheral neuropathy.http://journal.frontiersin.org/Journal/10.3389/fendo.2011.00104/fullMetabolismProgesteroneTestosteroneNeuroprotectionperipheral neuropathysteroidogenesis |
| spellingShingle | Roberto Cosimo eMelcangi Silvia eGiatti Marzia ePesaresi Donato eCarabrese Nico eMitro Donatella eCaruso Luis Miguel Garcia-Segura Role of neuroactive steroids in the peripheral nervous system Frontiers in Endocrinology Metabolism Progesterone Testosterone Neuroprotection peripheral neuropathy steroidogenesis |
| title | Role of neuroactive steroids in the peripheral nervous system |
| title_full | Role of neuroactive steroids in the peripheral nervous system |
| title_fullStr | Role of neuroactive steroids in the peripheral nervous system |
| title_full_unstemmed | Role of neuroactive steroids in the peripheral nervous system |
| title_short | Role of neuroactive steroids in the peripheral nervous system |
| title_sort | role of neuroactive steroids in the peripheral nervous system |
| topic | Metabolism Progesterone Testosterone Neuroprotection peripheral neuropathy steroidogenesis |
| url | http://journal.frontiersin.org/Journal/10.3389/fendo.2011.00104/full |
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