Drug Repurposing for Paracoccidioidomycosis Through a Computational Chemogenomics Framework

Drug Repurposing for Paracoccidioidomycosis Through a Computational Chemogenomics Framework

Paracoccidioidomycosis (PCM) is the most prevalent endemic mycosis in Latin America. The disease is caused by fungi of the genus Paracoccidioides and mainly affects low-income rural workers after inhalation of fungal conidia suspended in the air. The current arsenal of chemotherapeutic agents requir...

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Bibliographic Details
Main Authors: Amanda Alves de Oliveira, Bruno Junior Neves, Lívia do Carmo Silva, Célia Maria de Almeida Soares, Carolina Horta Andrade, Maristela Pereira
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Microbiology
Subjects:
Paracoccidioides species
drug repurposing
genome-wide alignment
gene essentiality
molecular docking
in vitro assays
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.01301/full

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