A perspective on DNA damage-induced potentiation of the pentose phosphate shunt and reductive stress in chemoresistance
Metabolic rearrangements and genome instability are two hallmarks of cancer. Recent evidence from our laboratory demonstrates that persistent DNA lesions hampering transcription may cause glucose rerouting through the pentose phosphate shunt and reductive stress. Here, we highlight the relevance of...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2020-05-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2020.1733383 |
| _version_ | 1797677139259031552 |
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| author | Chiara Milanese Pier G. Mastroberardino |
| author_facet | Chiara Milanese Pier G. Mastroberardino |
| author_sort | Chiara Milanese |
| collection | DOAJ |
| description | Metabolic rearrangements and genome instability are two hallmarks of cancer. Recent evidence from our laboratory demonstrates that persistent DNA lesions hampering transcription may cause glucose rerouting through the pentose phosphate shunt and reductive stress. Here, we highlight the relevance of these findings for cancer and chemoresistance development. |
| first_indexed | 2024-03-11T22:40:35Z |
| format | Article |
| id | doaj.art-38ee3993d2e94ce08d35389aa635eb69 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:40:35Z |
| publishDate | 2020-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-38ee3993d2e94ce08d35389aa635eb692023-09-22T09:11:01ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562020-05-017310.1080/23723556.2020.17333831733383A perspective on DNA damage-induced potentiation of the pentose phosphate shunt and reductive stress in chemoresistanceChiara Milanese0Pier G. Mastroberardino1Erasmus University Medical CenterErasmus University Medical CenterMetabolic rearrangements and genome instability are two hallmarks of cancer. Recent evidence from our laboratory demonstrates that persistent DNA lesions hampering transcription may cause glucose rerouting through the pentose phosphate shunt and reductive stress. Here, we highlight the relevance of these findings for cancer and chemoresistance development.http://dx.doi.org/10.1080/23723556.2020.1733383dna damagedna repairmetabolismpentose phosphate pathwayredox |
| spellingShingle | Chiara Milanese Pier G. Mastroberardino A perspective on DNA damage-induced potentiation of the pentose phosphate shunt and reductive stress in chemoresistance Molecular & Cellular Oncology dna damage dna repair metabolism pentose phosphate pathway redox |
| title | A perspective on DNA damage-induced potentiation of the pentose phosphate shunt and reductive stress in chemoresistance |
| title_full | A perspective on DNA damage-induced potentiation of the pentose phosphate shunt and reductive stress in chemoresistance |
| title_fullStr | A perspective on DNA damage-induced potentiation of the pentose phosphate shunt and reductive stress in chemoresistance |
| title_full_unstemmed | A perspective on DNA damage-induced potentiation of the pentose phosphate shunt and reductive stress in chemoresistance |
| title_short | A perspective on DNA damage-induced potentiation of the pentose phosphate shunt and reductive stress in chemoresistance |
| title_sort | perspective on dna damage induced potentiation of the pentose phosphate shunt and reductive stress in chemoresistance |
| topic | dna damage dna repair metabolism pentose phosphate pathway redox |
| url | http://dx.doi.org/10.1080/23723556.2020.1733383 |
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