A perspective on DNA damage-induced potentiation of the pentose phosphate shunt and reductive stress in chemoresistance

A perspective on DNA damage-induced potentiation of the pentose phosphate shunt and reductive stress in chemoresistance

Metabolic rearrangements and genome instability are two hallmarks of cancer. Recent evidence from our laboratory demonstrates that persistent DNA lesions hampering transcription may cause glucose rerouting through the pentose phosphate shunt and reductive stress. Here, we highlight the relevance of...

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Bibliographic Details
Main Authors: Chiara Milanese, Pier G. Mastroberardino
Format: Article
Language:English
Published: Taylor & Francis Group 2020-05-01
Series:Molecular & Cellular Oncology
Subjects:
dna damage
dna repair
metabolism
pentose phosphate pathway
redox
Online Access:http://dx.doi.org/10.1080/23723556.2020.1733383

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