Analysis of incidence and prognostic significance <i>FLT3, c-KIT</i> and <i>NPM1</i> genes mutation in children with acute myeloid leukemia
Prognosis of patients with acute myeloid leukemia receiving intensive chemotherapy is defined as kariotyping anomalies, and mutations of genes responsible for surviving and self-maintenance leukemic cells. In the giving work incidence of mutation involving genes FLT3, c-KIT, NPM1 having prognostic v...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
ABV-press
2022-11-01
|
| Series: | Онкогематология |
| Subjects: | |
| Online Access: | https://oncohematology.abvpress.ru/ongm/article/view/783 |
| _version_ | 1797855457336885248 |
|---|---|
| author | L. V. Guk T. V. Savitskaya D. A. Domninsky V. O. Bobrinina M. M. Schneider A. A. Maschan O. V. Aleinikova |
| author_facet | L. V. Guk T. V. Savitskaya D. A. Domninsky V. O. Bobrinina M. M. Schneider A. A. Maschan O. V. Aleinikova |
| author_sort | L. V. Guk |
| collection | DOAJ |
| description | Prognosis of patients with acute myeloid leukemia receiving intensive chemotherapy is defined as kariotyping anomalies, and mutations of genes responsible for surviving and self-maintenance leukemic cells. In the giving work incidence of mutation involving genes FLT3, c-KIT, NPM1 having prognostic value in adults is analysed. Kynase domain FLT3 mutation in 18 from 83 patients (21.6%) was detected. 2 from 18 patients (11%) achieved complete remission, 5 from 18 patients (27.7%) with FLT3 mutations were refractory to therapy, two patients died from treatment complications, 9 from 18 (50%) relapsed. Only 2 patients (11%) are alive in continuous complete remission. с-KIT mutations detected in 14.2% (2/14 patients), and NPM1 mutations represented allelic polymorphism. Thus, kynase domain FLT3 mutation are prognostic unfavorable. |
| first_indexed | 2024-04-09T20:22:57Z |
| format | Article |
| id | doaj.art-38efe043a43a4d2aa46c334aadeaad03 |
| institution | Directory Open Access Journal |
| issn | 1818-8346 2413-4023 |
| language | Russian |
| last_indexed | 2024-04-09T20:22:57Z |
| publishDate | 2022-11-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Онкогематология |
| spelling | doaj.art-38efe043a43a4d2aa46c334aadeaad032023-03-30T20:15:16ZrusABV-pressОнкогематология1818-83462413-40232022-11-0104273210.17650/1818-8346-2009-0-4-27-32661Analysis of incidence and prognostic significance <i>FLT3, c-KIT</i> and <i>NPM1</i> genes mutation in children with acute myeloid leukemiaL. V. Guk0T. V. Savitskaya1D. A. Domninsky2V. O. Bobrinina3M. M. Schneider4A. A. Maschan5O. V. Aleinikova6Federal research center of pediatric hematology, oncology and immunologyRepublic Centre for Paediatric Oncology and HaematologyFederal research center of pediatric hematology, oncology and immunologyFederal research center of pediatric hematology, oncology and immunologyFederal research center of pediatric hematology, oncology and immunologyFederal research center of pediatric hematology, oncology and immunologyRepublic Centre for Paediatric Oncology and HaematologyPrognosis of patients with acute myeloid leukemia receiving intensive chemotherapy is defined as kariotyping anomalies, and mutations of genes responsible for surviving and self-maintenance leukemic cells. In the giving work incidence of mutation involving genes FLT3, c-KIT, NPM1 having prognostic value in adults is analysed. Kynase domain FLT3 mutation in 18 from 83 patients (21.6%) was detected. 2 from 18 patients (11%) achieved complete remission, 5 from 18 patients (27.7%) with FLT3 mutations were refractory to therapy, two patients died from treatment complications, 9 from 18 (50%) relapsed. Only 2 patients (11%) are alive in continuous complete remission. с-KIT mutations detected in 14.2% (2/14 patients), and NPM1 mutations represented allelic polymorphism. Thus, kynase domain FLT3 mutation are prognostic unfavorable.https://oncohematology.abvpress.ru/ongm/article/view/783acute myeloid leukemiachildren<i>flt3c-kitnpm1</i> genes |
| spellingShingle | L. V. Guk T. V. Savitskaya D. A. Domninsky V. O. Bobrinina M. M. Schneider A. A. Maschan O. V. Aleinikova Analysis of incidence and prognostic significance <i>FLT3, c-KIT</i> and <i>NPM1</i> genes mutation in children with acute myeloid leukemia Онкогематология acute myeloid leukemia children <i>flt3 c-kit npm1</i> genes |
| title | Analysis of incidence and prognostic significance <i>FLT3, c-KIT</i> and <i>NPM1</i> genes mutation in children with acute myeloid leukemia |
| title_full | Analysis of incidence and prognostic significance <i>FLT3, c-KIT</i> and <i>NPM1</i> genes mutation in children with acute myeloid leukemia |
| title_fullStr | Analysis of incidence and prognostic significance <i>FLT3, c-KIT</i> and <i>NPM1</i> genes mutation in children with acute myeloid leukemia |
| title_full_unstemmed | Analysis of incidence and prognostic significance <i>FLT3, c-KIT</i> and <i>NPM1</i> genes mutation in children with acute myeloid leukemia |
| title_short | Analysis of incidence and prognostic significance <i>FLT3, c-KIT</i> and <i>NPM1</i> genes mutation in children with acute myeloid leukemia |
| title_sort | analysis of incidence and prognostic significance i flt3 c kit i and i npm1 i genes mutation in children with acute myeloid leukemia |
| topic | acute myeloid leukemia children <i>flt3 c-kit npm1</i> genes |
| url | https://oncohematology.abvpress.ru/ongm/article/view/783 |
| work_keys_str_mv | AT lvguk analysisofincidenceandprognosticsignificanceiflt3ckitiandinpm1igenesmutationinchildrenwithacutemyeloidleukemia AT tvsavitskaya analysisofincidenceandprognosticsignificanceiflt3ckitiandinpm1igenesmutationinchildrenwithacutemyeloidleukemia AT dadomninsky analysisofincidenceandprognosticsignificanceiflt3ckitiandinpm1igenesmutationinchildrenwithacutemyeloidleukemia AT vobobrinina analysisofincidenceandprognosticsignificanceiflt3ckitiandinpm1igenesmutationinchildrenwithacutemyeloidleukemia AT mmschneider analysisofincidenceandprognosticsignificanceiflt3ckitiandinpm1igenesmutationinchildrenwithacutemyeloidleukemia AT aamaschan analysisofincidenceandprognosticsignificanceiflt3ckitiandinpm1igenesmutationinchildrenwithacutemyeloidleukemia AT ovaleinikova analysisofincidenceandprognosticsignificanceiflt3ckitiandinpm1igenesmutationinchildrenwithacutemyeloidleukemia |