Underlying mechanisms and drug intervention strategies for the tumour microenvironment
Abstract Cancer occurs in a complex tissue environment, and its progression depends largely on the tumour microenvironment (TME). The TME has a highly complex and comprehensive system accompanied by dynamic changes and special biological characteristics, such as hypoxia, nutrient deficiency, inflamm...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-03-01
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| Series: | Journal of Experimental & Clinical Cancer Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13046-021-01893-y |
| _version_ | 1818616137776103424 |
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| author | Haoze Li Lihong Zhou Jing Zhou Qi Li Qing Ji |
| author_facet | Haoze Li Lihong Zhou Jing Zhou Qi Li Qing Ji |
| author_sort | Haoze Li |
| collection | DOAJ |
| description | Abstract Cancer occurs in a complex tissue environment, and its progression depends largely on the tumour microenvironment (TME). The TME has a highly complex and comprehensive system accompanied by dynamic changes and special biological characteristics, such as hypoxia, nutrient deficiency, inflammation, immunosuppression and cytokine production. In addition, a large number of cancer-associated biomolecules and signalling pathways are involved in the above bioprocesses. This paper reviews our understanding of the TME and describes its biological and molecular characterization in different stages of cancer development. Furthermore, we discuss in detail the intervention strategies for the critical points of the TME, including chemotherapy, targeted therapy, immunotherapy, natural products from traditional Chinese medicine, combined drug therapy, etc., providing a scientific basis for cancer therapy from the perspective of key molecular targets in the TME. |
| first_indexed | 2024-12-16T16:45:01Z |
| format | Article |
| id | doaj.art-38f03cf5429b434ab6d4b0291f808e6d |
| institution | Directory Open Access Journal |
| issn | 1756-9966 |
| language | English |
| last_indexed | 2024-12-16T16:45:01Z |
| publishDate | 2021-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Experimental & Clinical Cancer Research |
| spelling | doaj.art-38f03cf5429b434ab6d4b0291f808e6d2022-12-21T22:24:13ZengBMCJournal of Experimental & Clinical Cancer Research1756-99662021-03-0140112110.1186/s13046-021-01893-yUnderlying mechanisms and drug intervention strategies for the tumour microenvironmentHaoze Li0Lihong Zhou1Jing Zhou2Qi Li3Qing Ji4Department of Medical Oncology and Cancer Institute, Shuguang Hospital, Shanghai University of Traditional Chinese MedicineDepartment of Medical Oncology and Cancer Institute, Shuguang Hospital, Shanghai University of Traditional Chinese MedicineDepartment of Medical Oncology and Cancer Institute, Shuguang Hospital, Shanghai University of Traditional Chinese MedicineDepartment of Medical Oncology and Cancer Institute, Shuguang Hospital, Shanghai University of Traditional Chinese MedicineDepartment of Medical Oncology and Cancer Institute, Shuguang Hospital, Shanghai University of Traditional Chinese MedicineAbstract Cancer occurs in a complex tissue environment, and its progression depends largely on the tumour microenvironment (TME). The TME has a highly complex and comprehensive system accompanied by dynamic changes and special biological characteristics, such as hypoxia, nutrient deficiency, inflammation, immunosuppression and cytokine production. In addition, a large number of cancer-associated biomolecules and signalling pathways are involved in the above bioprocesses. This paper reviews our understanding of the TME and describes its biological and molecular characterization in different stages of cancer development. Furthermore, we discuss in detail the intervention strategies for the critical points of the TME, including chemotherapy, targeted therapy, immunotherapy, natural products from traditional Chinese medicine, combined drug therapy, etc., providing a scientific basis for cancer therapy from the perspective of key molecular targets in the TME.https://doi.org/10.1186/s13046-021-01893-yTMECancer developmentMolecular targetsDrug intervention strategies |
| spellingShingle | Haoze Li Lihong Zhou Jing Zhou Qi Li Qing Ji Underlying mechanisms and drug intervention strategies for the tumour microenvironment Journal of Experimental & Clinical Cancer Research TME Cancer development Molecular targets Drug intervention strategies |
| title | Underlying mechanisms and drug intervention strategies for the tumour microenvironment |
| title_full | Underlying mechanisms and drug intervention strategies for the tumour microenvironment |
| title_fullStr | Underlying mechanisms and drug intervention strategies for the tumour microenvironment |
| title_full_unstemmed | Underlying mechanisms and drug intervention strategies for the tumour microenvironment |
| title_short | Underlying mechanisms and drug intervention strategies for the tumour microenvironment |
| title_sort | underlying mechanisms and drug intervention strategies for the tumour microenvironment |
| topic | TME Cancer development Molecular targets Drug intervention strategies |
| url | https://doi.org/10.1186/s13046-021-01893-y |
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