Low-cost and clinically applicable copy number profiling using repeat DNA

Low-cost and clinically applicable copy number profiling using repeat DNA

Abstract Background Somatic copy number alterations (SCNAs) are an important class of genomic alteration in cancer. They are frequently observed in cancer samples, with studies showing that, on average, SCNAs affect 34% of a cancer cell’s genome. Furthermore, SCNAs have been shown to be major driver...

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Bibliographic Details
Main Authors: Sam Abujudeh, Sebastian S. Zeki, Meta C.J. van Lanschot, Mark Pusung, Jamie M.J. Weaver, Xiaodun Li, Ayesha Noorani, Andrew J. Metz, Jan Bornschein, Lawrence Bower, Ahmad Miremadi, Rebecca C. Fitzgerald, Edward R. Morrissey, Andy G. Lynch
Format: Article
Language:English
Published: BMC 2022-08-01
Series:BMC Genomics
Subjects:
Somatic copy number alterations
Copy number profiling
Cancer
Oesophageal adenocarcinoma
Barrett’s oesophagus
Tumour purity
Online Access:https://doi.org/10.1186/s12864-022-08681-8

Internet

https://doi.org/10.1186/s12864-022-08681-8

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