Curcumin Derivative GT863 Inhibits Amyloid-Beta Production via Inhibition of Protein N-Glycosylation

Curcumin Derivative GT863 Inhibits Amyloid-Beta Production via Inhibition of Protein N-Glycosylation

Amyloid-β (Aβ) peptides play a crucial role in the pathogenesis of Alzheimer’s disease (AD). Aβ production, aggregation, and clearance are thought to be important therapeutic targets for AD. Curcumin has been known to have an anti-amyloidogenic effect on AD. In t...

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Bibliographic Details
Main Authors: Yasuomi Urano, Mina Takahachi, Ryo Higashiura, Hitomi Fujiwara, Satoru Funamoto, So Imai, Eugene Futai, Michiaki Okuda, Hachiro Sugimoto, Noriko Noguchi
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cells
Subjects:
alzheimer’s disease
amyloid-β peptides
curcumin derivatives
glycosylation
Online Access:https://www.mdpi.com/2073-4409/9/2/349

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