CRISPR/Cas9 Methodology for the Generation of Knockout Deletions in Caenorhabditis elegans

CRISPR/Cas9 Methodology for the Generation of Knockout Deletions in Caenorhabditis elegans

The Caenorhabditis elegans Gene Knockout Consortium is tasked with obtaining null mutations in each of the more than 20,000 open reading frames (ORFs) of this organism. To date, approximately 15,000 ORFs have associated putative null alleles. As there has been substantial success in using CRISPR/Cas...

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Bibliographic Details
Main Authors: Vinci Au, Erica Li-Leger, Greta Raymant, Stephane Flibotte, George Chen, Kiana Martin, Lisa Fernando, Claudia Doell, Federico I. Rosell, Su Wang, Mark L. Edgley, Ann E. Rougvie, Harald Hutter, Donald G. Moerman
Format: Article
Language:English
Published: Oxford University Press 2019-01-01
Series:G3: Genes, Genomes, Genetics
Subjects:
C. elegans
CRISPR/Cas9
homology dependent repair
mutagenesis
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.118.200778

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