Co-Exposure of Polycyclic Aromatic Hydrocarbons and Phthalates with Blood Cell-Based Inflammation in Early Pregnant Women
Cumulative evidence has demonstrated that exposure to polycyclic aromatic hydrocarbons (PAHs) or phthalates (PAEs) contributes to a variety of adverse health effects. However, the association of PAHs and PAEs co-exposure with blood cell-based inflammatory indicators during early pregnancy is still u...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Toxics |
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| Online Access: | https://www.mdpi.com/2305-6304/11/10/810 |
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| author | Yunxiao Yang Ting Wang Lei Luo Qian He Fangfei Guo Zhongbao Chen Yijun Liu Xingyan Liu Yan Xie Xuejun Shang Xubo Shen Yuanzhong Zhou Kunming Tian |
| author_facet | Yunxiao Yang Ting Wang Lei Luo Qian He Fangfei Guo Zhongbao Chen Yijun Liu Xingyan Liu Yan Xie Xuejun Shang Xubo Shen Yuanzhong Zhou Kunming Tian |
| author_sort | Yunxiao Yang |
| collection | DOAJ |
| description | Cumulative evidence has demonstrated that exposure to polycyclic aromatic hydrocarbons (PAHs) or phthalates (PAEs) contributes to a variety of adverse health effects. However, the association of PAHs and PAEs co-exposure with blood cell-based inflammatory indicators during early pregnancy is still unclear. We aimed to investigate the single and mixed associations of exposure to PAHs and PAEs with blood cell-based inflammatory indicators among early pregnant women. A total of 318 early pregnant women were included in this study. General linear regressions were used to estimate the relationships of individual OH-PAHs and mPAEs with blood cell-based inflammatory indicators. The key pollutants were selected by an adapted least absolute shrinkage and selection operator (LASSO) penalized regression model and wasemployed to build the Bayesian kernel machine regression (BKMR) and quantile g-computation (Q-g) models, which can assess the joint association of OH-PAHs and mPAEs with blood cell-based inflammatory indicators. General linear regression indicated that each 1% increase in MOP was associated with a 4.92% (95% CI: 2.12%, 7.68%), 3.25% (95% CI: 0.50%, 6.18%), 5.87% (95% CI: 2.22%, 9.64%), and 6.50% (95% CI: 3.46%, 9.64%) increase in WBC, lymphocytes, neutrophils, and monocytes, respectively. BKMR and Q-g analysis showed that the mixture of OH-PAHs and mPAEs was linked with increased levels of white blood cells (WBC), neutrophils, monocytes, and lymphocytes, and MOP was identified as the dominant contributor. OH-PAHs and mPAEs co-exposure in early pregnancy was associated with elevated blood cell-based inflammatory indicators reactions. More attention should be paid to the inflammation induced by environmental pollution for perinatal women, especially early pregnant women. |
| first_indexed | 2024-03-10T20:50:53Z |
| format | Article |
| id | doaj.art-38f3fed47d434544834e13ee00954a5e |
| institution | Directory Open Access Journal |
| issn | 2305-6304 |
| language | English |
| last_indexed | 2024-03-10T20:50:53Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj.art-38f3fed47d434544834e13ee00954a5e2023-11-19T18:21:17ZengMDPI AGToxics2305-63042023-09-01111081010.3390/toxics11100810Co-Exposure of Polycyclic Aromatic Hydrocarbons and Phthalates with Blood Cell-Based Inflammation in Early Pregnant WomenYunxiao Yang0Ting Wang1Lei Luo2Qian He3Fangfei Guo4Zhongbao Chen5Yijun Liu6Xingyan Liu7Yan Xie8Xuejun Shang9Xubo Shen10Yuanzhong Zhou11Kunming Tian12School of Nursing, Zunyi Medical University, Zunyi 563000, ChinaSchool of Health Policy and Management, Nanjing Medical University, Nanjing 210000, ChinaSchool of Public Health, Zunyi Medical University, Zunyi 563000, ChinaDepartment of Obstetrics and Gynecology, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, ChinaSchool of Public Health, Guizhou Medical University, Guiyang 550000, ChinaRenhuai Center for Disease Control and Prevention, Zunyi 563000, ChinaSchool of Public Health, Zunyi Medical University, Zunyi 563000, ChinaSchool of Public Health, Zunyi Medical University, Zunyi 563000, ChinaSchool of Public Health, Zunyi Medical University, Zunyi 563000, ChinaDepartment of Andrology, School of Medicine, Jinling Hospital, Nanjing University, Nanjing 210002, ChinaSchool of Public Health, Zunyi Medical University, Zunyi 563000, ChinaSchool of Public Health, Zunyi Medical University, Zunyi 563000, ChinaSchool of Public Health, Zunyi Medical University, Zunyi 563000, ChinaCumulative evidence has demonstrated that exposure to polycyclic aromatic hydrocarbons (PAHs) or phthalates (PAEs) contributes to a variety of adverse health effects. However, the association of PAHs and PAEs co-exposure with blood cell-based inflammatory indicators during early pregnancy is still unclear. We aimed to investigate the single and mixed associations of exposure to PAHs and PAEs with blood cell-based inflammatory indicators among early pregnant women. A total of 318 early pregnant women were included in this study. General linear regressions were used to estimate the relationships of individual OH-PAHs and mPAEs with blood cell-based inflammatory indicators. The key pollutants were selected by an adapted least absolute shrinkage and selection operator (LASSO) penalized regression model and wasemployed to build the Bayesian kernel machine regression (BKMR) and quantile g-computation (Q-g) models, which can assess the joint association of OH-PAHs and mPAEs with blood cell-based inflammatory indicators. General linear regression indicated that each 1% increase in MOP was associated with a 4.92% (95% CI: 2.12%, 7.68%), 3.25% (95% CI: 0.50%, 6.18%), 5.87% (95% CI: 2.22%, 9.64%), and 6.50% (95% CI: 3.46%, 9.64%) increase in WBC, lymphocytes, neutrophils, and monocytes, respectively. BKMR and Q-g analysis showed that the mixture of OH-PAHs and mPAEs was linked with increased levels of white blood cells (WBC), neutrophils, monocytes, and lymphocytes, and MOP was identified as the dominant contributor. OH-PAHs and mPAEs co-exposure in early pregnancy was associated with elevated blood cell-based inflammatory indicators reactions. More attention should be paid to the inflammation induced by environmental pollution for perinatal women, especially early pregnant women.https://www.mdpi.com/2305-6304/11/10/810pregnancyBKMRQ-gInflammationPAHsPAEs |
| spellingShingle | Yunxiao Yang Ting Wang Lei Luo Qian He Fangfei Guo Zhongbao Chen Yijun Liu Xingyan Liu Yan Xie Xuejun Shang Xubo Shen Yuanzhong Zhou Kunming Tian Co-Exposure of Polycyclic Aromatic Hydrocarbons and Phthalates with Blood Cell-Based Inflammation in Early Pregnant Women Toxics pregnancy BKMR Q-g Inflammation PAHs PAEs |
| title | Co-Exposure of Polycyclic Aromatic Hydrocarbons and Phthalates with Blood Cell-Based Inflammation in Early Pregnant Women |
| title_full | Co-Exposure of Polycyclic Aromatic Hydrocarbons and Phthalates with Blood Cell-Based Inflammation in Early Pregnant Women |
| title_fullStr | Co-Exposure of Polycyclic Aromatic Hydrocarbons and Phthalates with Blood Cell-Based Inflammation in Early Pregnant Women |
| title_full_unstemmed | Co-Exposure of Polycyclic Aromatic Hydrocarbons and Phthalates with Blood Cell-Based Inflammation in Early Pregnant Women |
| title_short | Co-Exposure of Polycyclic Aromatic Hydrocarbons and Phthalates with Blood Cell-Based Inflammation in Early Pregnant Women |
| title_sort | co exposure of polycyclic aromatic hydrocarbons and phthalates with blood cell based inflammation in early pregnant women |
| topic | pregnancy BKMR Q-g Inflammation PAHs PAEs |
| url | https://www.mdpi.com/2305-6304/11/10/810 |
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