Differential Expression of Growth-, Angiogenesis- and Invasion-Related Factors in The Development of Placenta Accreta
Placenta accreta is the major cause of maternal death complicated by massive peripartum hemorrhage. Its development is traditionally considered to be related to a decidual defect caused by previous cesarean deliveries or uterine curettages. Usually, placental villi firmly adhere to the superficial m...
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| Format: | Article |
| Language: | English |
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Elsevier
2006-06-01
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| Series: | Taiwanese Journal of Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1028455909602059 |
| _version_ | 1818145833486385152 |
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| author | Jenn-Jhy Tseng Min-Min Chou |
| author_facet | Jenn-Jhy Tseng Min-Min Chou |
| author_sort | Jenn-Jhy Tseng |
| collection | DOAJ |
| description | Placenta accreta is the major cause of maternal death complicated by massive peripartum hemorrhage. Its development is traditionally considered to be related to a decidual defect caused by previous cesarean deliveries or uterine curettages. Usually, placental villi firmly adhere to the superficial myometrium and deeply invade, or even penetrate, the uterine wall. Abnormal uteroplacental neovascularization is another characteristic. Therefore, we hypothesized that placenta accreta develops as a result of abnormal expressions of growth-, angiogenesis- and invasion-related factors in trophoblast populations. We have found, in pregnancies complicated by placenta accreta: upregulated epidermal growth factor receptor and downregulated c-erbB-2 oncoprotein in syncytiotrophoblasts; downregulated vasculoendothelial growth factor receptor-2 expression in syncytiotrophoblasts and increased vasculoendothelial growth factor in placental lysates; and downregulated Tie-2 expression in syncytiotrophoblasts and enhanced angiopoietin-2 level in placental lysates. However, matrix metalloproteinase expression was not upregulated, so the association of these invasion-related molecules with placenta accreta is less likely. Taken together, these findings imply that complex factors, either alone or in combination, might be responsible for the development of placenta accreta. Further studies are needed to understand the signaling pathways and possible genetic events. |
| first_indexed | 2024-12-11T12:09:44Z |
| format | Article |
| id | doaj.art-38f490d70c4140818bebe6faef315502 |
| institution | Directory Open Access Journal |
| issn | 1028-4559 |
| language | English |
| last_indexed | 2024-12-11T12:09:44Z |
| publishDate | 2006-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Taiwanese Journal of Obstetrics & Gynecology |
| spelling | doaj.art-38f490d70c4140818bebe6faef3155022022-12-22T01:07:50ZengElsevierTaiwanese Journal of Obstetrics & Gynecology1028-45592006-06-0145210010610.1016/S1028-4559(09)60205-9Differential Expression of Growth-, Angiogenesis- and Invasion-Related Factors in The Development of Placenta AccretaJenn-Jhy Tseng0Min-Min Chou1Department of Obstetrics and Gynecology, Taichung Veterans General Hospital, Taichung, TaiwanDepartment of Obstetrics and Gynecology, Taichung Veterans General Hospital, Taichung, TaiwanPlacenta accreta is the major cause of maternal death complicated by massive peripartum hemorrhage. Its development is traditionally considered to be related to a decidual defect caused by previous cesarean deliveries or uterine curettages. Usually, placental villi firmly adhere to the superficial myometrium and deeply invade, or even penetrate, the uterine wall. Abnormal uteroplacental neovascularization is another characteristic. Therefore, we hypothesized that placenta accreta develops as a result of abnormal expressions of growth-, angiogenesis- and invasion-related factors in trophoblast populations. We have found, in pregnancies complicated by placenta accreta: upregulated epidermal growth factor receptor and downregulated c-erbB-2 oncoprotein in syncytiotrophoblasts; downregulated vasculoendothelial growth factor receptor-2 expression in syncytiotrophoblasts and increased vasculoendothelial growth factor in placental lysates; and downregulated Tie-2 expression in syncytiotrophoblasts and enhanced angiopoietin-2 level in placental lysates. However, matrix metalloproteinase expression was not upregulated, so the association of these invasion-related molecules with placenta accreta is less likely. Taken together, these findings imply that complex factors, either alone or in combination, might be responsible for the development of placenta accreta. Further studies are needed to understand the signaling pathways and possible genetic events.http://www.sciencedirect.com/science/article/pii/S1028455909602059angiogenesisgrowthinvasionplacenta accretatrophoblast |
| spellingShingle | Jenn-Jhy Tseng Min-Min Chou Differential Expression of Growth-, Angiogenesis- and Invasion-Related Factors in The Development of Placenta Accreta Taiwanese Journal of Obstetrics & Gynecology angiogenesis growth invasion placenta accreta trophoblast |
| title | Differential Expression of Growth-, Angiogenesis- and Invasion-Related Factors in The Development of Placenta Accreta |
| title_full | Differential Expression of Growth-, Angiogenesis- and Invasion-Related Factors in The Development of Placenta Accreta |
| title_fullStr | Differential Expression of Growth-, Angiogenesis- and Invasion-Related Factors in The Development of Placenta Accreta |
| title_full_unstemmed | Differential Expression of Growth-, Angiogenesis- and Invasion-Related Factors in The Development of Placenta Accreta |
| title_short | Differential Expression of Growth-, Angiogenesis- and Invasion-Related Factors in The Development of Placenta Accreta |
| title_sort | differential expression of growth angiogenesis and invasion related factors in the development of placenta accreta |
| topic | angiogenesis growth invasion placenta accreta trophoblast |
| url | http://www.sciencedirect.com/science/article/pii/S1028455909602059 |
| work_keys_str_mv | AT jennjhytseng differentialexpressionofgrowthangiogenesisandinvasionrelatedfactorsinthedevelopmentofplacentaaccreta AT minminchou differentialexpressionofgrowthangiogenesisandinvasionrelatedfactorsinthedevelopmentofplacentaaccreta |