Clinical Overview of Progressive Fibrotic Interstitial Lung Disease
Interstitial lung diseases (ILD) on the whole have variable prognoses, but there are those which manifest with fibrosis and are characterized by disease progression. Chief among these is idiopathic pulmonary fibrosis, but other ILDs, including autoimmune ILD and chronic hypersensitivity pneumonitis,...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.858339/full |
| _version_ | 1818140698719813632 |
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| author | Amy Hajari Case |
| author_facet | Amy Hajari Case |
| author_sort | Amy Hajari Case |
| collection | DOAJ |
| description | Interstitial lung diseases (ILD) on the whole have variable prognoses, but there are those which manifest with fibrosis and are characterized by disease progression. Chief among these is idiopathic pulmonary fibrosis, but other ILDs, including autoimmune ILD and chronic hypersensitivity pneumonitis, may have a progressive fibrotic phenotype also. A usual interstitial pneumonia pattern of lung involvement is a prominent risk factor for such a course, suggesting shared fibrotic pathways that may be targeted by antifibrotic therapies. This brief review describes ILDs that are most commonly fibrotic, shared risk factors for development of PF-ILD, and evidence for antifibrotic use in their management. |
| first_indexed | 2024-12-11T10:48:07Z |
| format | Article |
| id | doaj.art-38f6a8c51d6340d1bcf066a80de6f951 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-11T10:48:07Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-38f6a8c51d6340d1bcf066a80de6f9512022-12-22T01:10:25ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-03-01910.3389/fmed.2022.858339858339Clinical Overview of Progressive Fibrotic Interstitial Lung DiseaseAmy Hajari CaseInterstitial lung diseases (ILD) on the whole have variable prognoses, but there are those which manifest with fibrosis and are characterized by disease progression. Chief among these is idiopathic pulmonary fibrosis, but other ILDs, including autoimmune ILD and chronic hypersensitivity pneumonitis, may have a progressive fibrotic phenotype also. A usual interstitial pneumonia pattern of lung involvement is a prominent risk factor for such a course, suggesting shared fibrotic pathways that may be targeted by antifibrotic therapies. This brief review describes ILDs that are most commonly fibrotic, shared risk factors for development of PF-ILD, and evidence for antifibrotic use in their management.https://www.frontiersin.org/articles/10.3389/fmed.2022.858339/fullpulmonary fibrosisinterstitial lung disease (ILD)connective tissue disease-associated ILDhypersensitivity pneumonitis (HP)antifibrotic |
| spellingShingle | Amy Hajari Case Clinical Overview of Progressive Fibrotic Interstitial Lung Disease Frontiers in Medicine pulmonary fibrosis interstitial lung disease (ILD) connective tissue disease-associated ILD hypersensitivity pneumonitis (HP) antifibrotic |
| title | Clinical Overview of Progressive Fibrotic Interstitial Lung Disease |
| title_full | Clinical Overview of Progressive Fibrotic Interstitial Lung Disease |
| title_fullStr | Clinical Overview of Progressive Fibrotic Interstitial Lung Disease |
| title_full_unstemmed | Clinical Overview of Progressive Fibrotic Interstitial Lung Disease |
| title_short | Clinical Overview of Progressive Fibrotic Interstitial Lung Disease |
| title_sort | clinical overview of progressive fibrotic interstitial lung disease |
| topic | pulmonary fibrosis interstitial lung disease (ILD) connective tissue disease-associated ILD hypersensitivity pneumonitis (HP) antifibrotic |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.858339/full |
| work_keys_str_mv | AT amyhajaricase clinicaloverviewofprogressivefibroticinterstitiallungdisease |