Extended blood group profiles for Malays, Chinese, and Indians in peninsular Malaysia
Abstract Background Blood group antigens are immunogenic polymorphic molecules presented on the surface of RBCs. This study aimed to determine extended blood group profiles (ABO, Rhesus, Kell, Kidd, Duffy, MNS, Cartwright, Dombrock, Colton, Lutheran, and Vel) in Malays, Chinese, and Indians in Penin...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2020-12-01
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| Series: | Egyptian Journal of Medical Human Genetics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43042-020-00096-y |
| _version_ | 1819173857918976000 |
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| author | Che Ghazali Norul Hajar Zulkafli Zefarina Nor Suhaila Md. Riffin Tuan Hulwani Tuan Mohammad Mohd Nazri Hassan Prathapan Poonachi Sabreena Safuan Gehad ElGhazali Geoffrey Keith Chambers Hisham Atan Edinur |
| author_facet | Che Ghazali Norul Hajar Zulkafli Zefarina Nor Suhaila Md. Riffin Tuan Hulwani Tuan Mohammad Mohd Nazri Hassan Prathapan Poonachi Sabreena Safuan Gehad ElGhazali Geoffrey Keith Chambers Hisham Atan Edinur |
| author_sort | Che Ghazali Norul Hajar |
| collection | DOAJ |
| description | Abstract Background Blood group antigens are immunogenic polymorphic molecules presented on the surface of RBCs. This study aimed to determine extended blood group profiles (ABO, Rhesus, Kell, Kidd, Duffy, MNS, Cartwright, Dombrock, Colton, Lutheran, and Vel) in Malays, Chinese, and Indians in Peninsular Malaysia. Results Here, ABO Type O, DCCee, MNs, and Fy (a+b−) were the most frequent major blood group phenotypes in all three ethnic groups. Other minor blood group systems distributed differently across these ethnic groups, except for the Kell, Lutheran, Cartwright, and Vel blood group systems, where only K+k−, Lu (8+14), Yt (a+b−), and Vel (+) phenotypes were observed. Exact tests of population differentiation generally showed no significant differences between Malays included in the present study vs. other ethnically similar datasets from previous surveys. However, many significant differences were recorded in comparison between blood group datasets from ethnically unrelated populations (Malays vs. Chinese vs. Indians) especially for Rhesus, Kidd, and Duffy blood group systems. A Principal component analysis (PCA) plot showed that population groups from the Peninsular Malaysia map closely together as compared with population groups from other geographical regions. Conclusions Overall, our present study has successfully provided an extended blood group profiles for Malays, Chinese, and Indians in Peninsular Malaysia. These new blood group datasets can be used as guidelines for donor recruitment and as reference standards for studying diseases associated with blood group systems. |
| first_indexed | 2024-12-22T20:29:45Z |
| format | Article |
| id | doaj.art-38f6ea9cac4a450595cc3bc2bcedc3e5 |
| institution | Directory Open Access Journal |
| issn | 2090-2441 |
| language | English |
| last_indexed | 2024-12-22T20:29:45Z |
| publishDate | 2020-12-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Journal of Medical Human Genetics |
| spelling | doaj.art-38f6ea9cac4a450595cc3bc2bcedc3e52022-12-21T18:13:37ZengSpringerOpenEgyptian Journal of Medical Human Genetics2090-24412020-12-0121111010.1186/s43042-020-00096-yExtended blood group profiles for Malays, Chinese, and Indians in peninsular MalaysiaChe Ghazali Norul Hajar0Zulkafli Zefarina1Nor Suhaila Md. Riffin2Tuan Hulwani Tuan Mohammad3Mohd Nazri Hassan4Prathapan Poonachi5Sabreena Safuan6Gehad ElGhazali7Geoffrey Keith Chambers8Hisham Atan Edinur9School of Health Sciences, Universiti Sains Malaysia, Health CampusHospital Universiti Sains Malaysia, Universiti Sains MalaysiaHospital Sultan Haji Ahmad ShahHospital Seberang JayaHospital Universiti Sains Malaysia, Universiti Sains MalaysiaSchool of Health Sciences, Universiti Sains Malaysia, Health CampusSchool of Health Sciences, Universiti Sains Malaysia, Health CampusDepartment of Immunology, Pathology and Laboratory Medicine Services, Sheikh Khalifa Medical CitySchool of Biological Sciences, Victoria University of WellingtonSchool of Health Sciences, Universiti Sains Malaysia, Health CampusAbstract Background Blood group antigens are immunogenic polymorphic molecules presented on the surface of RBCs. This study aimed to determine extended blood group profiles (ABO, Rhesus, Kell, Kidd, Duffy, MNS, Cartwright, Dombrock, Colton, Lutheran, and Vel) in Malays, Chinese, and Indians in Peninsular Malaysia. Results Here, ABO Type O, DCCee, MNs, and Fy (a+b−) were the most frequent major blood group phenotypes in all three ethnic groups. Other minor blood group systems distributed differently across these ethnic groups, except for the Kell, Lutheran, Cartwright, and Vel blood group systems, where only K+k−, Lu (8+14), Yt (a+b−), and Vel (+) phenotypes were observed. Exact tests of population differentiation generally showed no significant differences between Malays included in the present study vs. other ethnically similar datasets from previous surveys. However, many significant differences were recorded in comparison between blood group datasets from ethnically unrelated populations (Malays vs. Chinese vs. Indians) especially for Rhesus, Kidd, and Duffy blood group systems. A Principal component analysis (PCA) plot showed that population groups from the Peninsular Malaysia map closely together as compared with population groups from other geographical regions. Conclusions Overall, our present study has successfully provided an extended blood group profiles for Malays, Chinese, and Indians in Peninsular Malaysia. These new blood group datasets can be used as guidelines for donor recruitment and as reference standards for studying diseases associated with blood group systems.https://doi.org/10.1186/s43042-020-00096-yBlood groupRBCsPeninsular MalaysiaMalaysChineseIndians |
| spellingShingle | Che Ghazali Norul Hajar Zulkafli Zefarina Nor Suhaila Md. Riffin Tuan Hulwani Tuan Mohammad Mohd Nazri Hassan Prathapan Poonachi Sabreena Safuan Gehad ElGhazali Geoffrey Keith Chambers Hisham Atan Edinur Extended blood group profiles for Malays, Chinese, and Indians in peninsular Malaysia Egyptian Journal of Medical Human Genetics Blood group RBCs Peninsular Malaysia Malays Chinese Indians |
| title | Extended blood group profiles for Malays, Chinese, and Indians in peninsular Malaysia |
| title_full | Extended blood group profiles for Malays, Chinese, and Indians in peninsular Malaysia |
| title_fullStr | Extended blood group profiles for Malays, Chinese, and Indians in peninsular Malaysia |
| title_full_unstemmed | Extended blood group profiles for Malays, Chinese, and Indians in peninsular Malaysia |
| title_short | Extended blood group profiles for Malays, Chinese, and Indians in peninsular Malaysia |
| title_sort | extended blood group profiles for malays chinese and indians in peninsular malaysia |
| topic | Blood group RBCs Peninsular Malaysia Malays Chinese Indians |
| url | https://doi.org/10.1186/s43042-020-00096-y |
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