Molecular Mechanisms of Action of Undenatured Type II Collagen: Experimental and Clinical Evidence
In the treatment of joint diseases, including osteoarthritis (OA), the use of standardized extracts of undenatured type II collagen (UDC-II) is promising. It is known that UDC-II is involved in the regulation of innate and adaptive immunity (reduction of autoimmune reactions that stimulate cartilage...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
IMA-PRESS LLC
2022-10-01
|
| Series: | Современная ревматология |
| Subjects: | |
| Online Access: | https://mrj.ima-press.net/mrj/article/view/1355 |
| _version_ | 1797876655733080064 |
|---|---|
| author | O. A. Gromova I. Yu. Torshin A. M. Lila |
| author_facet | O. A. Gromova I. Yu. Torshin A. M. Lila |
| author_sort | O. A. Gromova |
| collection | DOAJ |
| description | In the treatment of joint diseases, including osteoarthritis (OA), the use of standardized extracts of undenatured type II collagen (UDC-II) is promising. It is known that UDC-II is involved in the regulation of innate and adaptive immunity (reduction of autoimmune reactions that stimulate cartilage degradation) and in the reduction of chronic inflammation activity (modulation of cytokines and prostaglandins). The effect of UDC-II on discoidin receptors of chondrocytes helps to prevent structural disorders of the cartilage connective tissue. Experimental and clinical studies have shown that under the influence of standardized UDC-II, there is an increase in the proportion of regulatory CD4+ T cells, a decrease in the levels of pro-inflammatory cytokines, such as interleukin (IL) 1β, IL6, tumor necrosis factor α, CRP, prostaglandins in the blood, as well as matrix metalloproteinase 3 and NF-κB expression in cartilage. The use of UDC-II in OA leads to a significant reduction in pain, an increase in the range of joint motion, an improvement in joint function according to WOMAC and quality of life. |
| first_indexed | 2024-04-10T02:05:09Z |
| format | Article |
| id | doaj.art-38f95ea52d524fbaa132a3a40732ee1f |
| institution | Directory Open Access Journal |
| issn | 1996-7012 2310-158X |
| language | Russian |
| last_indexed | 2024-04-10T02:05:09Z |
| publishDate | 2022-10-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Современная ревматология |
| spelling | doaj.art-38f95ea52d524fbaa132a3a40732ee1f2023-03-13T08:39:30ZrusIMA-PRESS LLCСовременная ревматология1996-70122310-158X2022-10-0116510811310.14412/1996-7012-2022-5-108-1132526Molecular Mechanisms of Action of Undenatured Type II Collagen: Experimental and Clinical EvidenceO. A. Gromova0I. Yu. Torshin1A. M. Lila2Институт фармакоинформатики Федерального исследовательского центра «Информатика и управление» Российской академии наукИнститут фармакоинформатики Федерального исследовательского центра «Информатика и управление» Российской академии наукФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»; Кафедра ревматологии ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииIn the treatment of joint diseases, including osteoarthritis (OA), the use of standardized extracts of undenatured type II collagen (UDC-II) is promising. It is known that UDC-II is involved in the regulation of innate and adaptive immunity (reduction of autoimmune reactions that stimulate cartilage degradation) and in the reduction of chronic inflammation activity (modulation of cytokines and prostaglandins). The effect of UDC-II on discoidin receptors of chondrocytes helps to prevent structural disorders of the cartilage connective tissue. Experimental and clinical studies have shown that under the influence of standardized UDC-II, there is an increase in the proportion of regulatory CD4+ T cells, a decrease in the levels of pro-inflammatory cytokines, such as interleukin (IL) 1β, IL6, tumor necrosis factor α, CRP, prostaglandins in the blood, as well as matrix metalloproteinase 3 and NF-κB expression in cartilage. The use of UDC-II in OA leads to a significant reduction in pain, an increase in the range of joint motion, an improvement in joint function according to WOMAC and quality of life.https://mrj.ima-press.net/mrj/article/view/1355неденатурированный коллаген ii типаостеоартритгипералгезияцитокиныбиоинформатика |
| spellingShingle | O. A. Gromova I. Yu. Torshin A. M. Lila Molecular Mechanisms of Action of Undenatured Type II Collagen: Experimental and Clinical Evidence Современная ревматология неденатурированный коллаген ii типа остеоартрит гипералгезия цитокины биоинформатика |
| title | Molecular Mechanisms of Action of Undenatured Type II Collagen: Experimental and Clinical Evidence |
| title_full | Molecular Mechanisms of Action of Undenatured Type II Collagen: Experimental and Clinical Evidence |
| title_fullStr | Molecular Mechanisms of Action of Undenatured Type II Collagen: Experimental and Clinical Evidence |
| title_full_unstemmed | Molecular Mechanisms of Action of Undenatured Type II Collagen: Experimental and Clinical Evidence |
| title_short | Molecular Mechanisms of Action of Undenatured Type II Collagen: Experimental and Clinical Evidence |
| title_sort | molecular mechanisms of action of undenatured type ii collagen experimental and clinical evidence |
| topic | неденатурированный коллаген ii типа остеоартрит гипералгезия цитокины биоинформатика |
| url | https://mrj.ima-press.net/mrj/article/view/1355 |
| work_keys_str_mv | AT oagromova molecularmechanismsofactionofundenaturedtypeiicollagenexperimentalandclinicalevidence AT iyutorshin molecularmechanismsofactionofundenaturedtypeiicollagenexperimentalandclinicalevidence AT amlila molecularmechanismsofactionofundenaturedtypeiicollagenexperimentalandclinicalevidence |