THE ROLE OF THE SOLUBLE TNF-ALPHA RECEPTORS IN TREATMENT OF JUVENILE IDIOPATHIC ARTHRITIS

THE ROLE OF THE SOLUBLE TNF-ALPHA RECEPTORS IN TREATMENT OF JUVENILE IDIOPATHIC ARTHRITIS

The results of the study of etanercept (soluble tumor necrosis factor alpha receptors) efficacy and safety in treatment of 97 patients with early and late onset of juvenile idiopathic arthritis are demonstrated in this article. The observation period was 12 months. In 48 weeks of anti-TNF treatment...

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Bibliographic Details
Main Authors: T. M. Bzarova, E. I. Alexeeva, A. N. Fetisova, N. A. Zurikova, S. I. Valieva, R. V. Denisova, E. V. Mitenko, T. V. Sleptsova, K. B. Isaeva, E. G. Chistyakova, N. I. Taibulatov, M. V. Ryazanov, A. V. Anikin, E. I. Zelikovich, G. V. Kurilenkov, E. L. Semikina
Format: Article
Language:English
Published: "Paediatrician" Publishers LLC 2012-07-01
Series:Вопросы современной педиатрии
Subjects:
ювенильный идиопатический артрит
этанерцепт
метотрексат
качество жизни
эффективность
безопасность
Online Access:https://vsp.spr-journal.ru/jour/article/view/451
Description
Summary:The results of the study of etanercept (soluble tumor necrosis factor alpha receptors) efficacy and safety in treatment of 97 patients with early and late onset of juvenile idiopathic arthritis are demonstrated in this article. The observation period was 12 months. In 48 weeks of anti-TNF treatment the achievement of clinical remission, decrease and normalization of laboratory markers of disease activity, complete restoration of joints function and improvement of life quality was established in 100% of children with early onset and 71% of children with late onset of arthritis. The drug was withdrawn in 13 (14%) patients: in 5 (6%) due to inefficiency, in 3 (4%) — due to development of side effects.
ISSN:1682-5527
1682-5535

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