Prognostic significance of CIP2A expression in solid tumors: A meta-analysis.
CIP2A, cancerous inhibitor of protein phosphatase 2A, was initially recognized as an oncoprotein. Recently several studies revealed that CIP2A could function as a prognosis biomarker, however, the result remained not comprehensive, partly due to small number of patients included individually. Here w...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC6059394?pdf=render |
| _version_ | 1811220205545717760 |
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| author | Min Tang Jiao-Feng Shen Ping Li Li-Na Zhou Ping Zeng Xi-Xi Cui Min-Bin Chen Ye Tian |
| author_facet | Min Tang Jiao-Feng Shen Ping Li Li-Na Zhou Ping Zeng Xi-Xi Cui Min-Bin Chen Ye Tian |
| author_sort | Min Tang |
| collection | DOAJ |
| description | CIP2A, cancerous inhibitor of protein phosphatase 2A, was initially recognized as an oncoprotein. Recently several studies revealed that CIP2A could function as a prognosis biomarker, however, the result remained not comprehensive, partly due to small number of patients included individually. Here we carried out a meta-analysis of published studies to assess the prognostic significance of CIP2A in solid tumors. All eligible studies were identified through searching PubMed, Embase and Web of Science database. In this meta-analysis, 22 studies involving 4,579 participants were included, and we verified that CIP2A over-expression was significantly related with poor overall survival (pooled HR = 1.844, 95% CI = 1.528-2.225, P<0.001) and short disease free survival (pooled HR = 1.808, 95% CI = 1.591-2.055, P<0.001) in solid tumors. Additionally, subgroup analysis suggested that the trend of a poor overall survival with an increased CIP2A expression was present in East-Asian and European patients, as well as in lung cancer and colorectal cancer. To sum up, CIP2A over-expression was associated with poor survival in human solid tumors and might be a predictive factor of poor prognosis. |
| first_indexed | 2024-04-12T07:37:44Z |
| format | Article |
| id | doaj.art-38fd1cdb7765418a9336a60fdce6b43b |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T07:37:44Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-38fd1cdb7765418a9336a60fdce6b43b2022-12-22T03:41:53ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01137e019967510.1371/journal.pone.0199675Prognostic significance of CIP2A expression in solid tumors: A meta-analysis.Min TangJiao-Feng ShenPing LiLi-Na ZhouPing ZengXi-Xi CuiMin-Bin ChenYe TianCIP2A, cancerous inhibitor of protein phosphatase 2A, was initially recognized as an oncoprotein. Recently several studies revealed that CIP2A could function as a prognosis biomarker, however, the result remained not comprehensive, partly due to small number of patients included individually. Here we carried out a meta-analysis of published studies to assess the prognostic significance of CIP2A in solid tumors. All eligible studies were identified through searching PubMed, Embase and Web of Science database. In this meta-analysis, 22 studies involving 4,579 participants were included, and we verified that CIP2A over-expression was significantly related with poor overall survival (pooled HR = 1.844, 95% CI = 1.528-2.225, P<0.001) and short disease free survival (pooled HR = 1.808, 95% CI = 1.591-2.055, P<0.001) in solid tumors. Additionally, subgroup analysis suggested that the trend of a poor overall survival with an increased CIP2A expression was present in East-Asian and European patients, as well as in lung cancer and colorectal cancer. To sum up, CIP2A over-expression was associated with poor survival in human solid tumors and might be a predictive factor of poor prognosis.http://europepmc.org/articles/PMC6059394?pdf=render |
| spellingShingle | Min Tang Jiao-Feng Shen Ping Li Li-Na Zhou Ping Zeng Xi-Xi Cui Min-Bin Chen Ye Tian Prognostic significance of CIP2A expression in solid tumors: A meta-analysis. PLoS ONE |
| title | Prognostic significance of CIP2A expression in solid tumors: A meta-analysis. |
| title_full | Prognostic significance of CIP2A expression in solid tumors: A meta-analysis. |
| title_fullStr | Prognostic significance of CIP2A expression in solid tumors: A meta-analysis. |
| title_full_unstemmed | Prognostic significance of CIP2A expression in solid tumors: A meta-analysis. |
| title_short | Prognostic significance of CIP2A expression in solid tumors: A meta-analysis. |
| title_sort | prognostic significance of cip2a expression in solid tumors a meta analysis |
| url | http://europepmc.org/articles/PMC6059394?pdf=render |
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