Prevalence and risk factors of fluid overload in Southern Chinese continuous ambulatory peritoneal dialysis patients.
BACKGROUND: Fluid overload is frequently present in CAPD patients and one of important predictors of mortality. The aim of this study is to investigate the prevalence and associated risk factors in a cohort study of Southern Chinese CAPD patients. METHODS: The patients (receiving CAPD 3 months and m...
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3544813?pdf=render |
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| author | Qunying Guo Chunyan Yi Jianying Li Xiaofeng Wu Xiao Yang Xueqing Yu |
| author_facet | Qunying Guo Chunyan Yi Jianying Li Xiaofeng Wu Xiao Yang Xueqing Yu |
| author_sort | Qunying Guo |
| collection | DOAJ |
| description | BACKGROUND: Fluid overload is frequently present in CAPD patients and one of important predictors of mortality. The aim of this study is to investigate the prevalence and associated risk factors in a cohort study of Southern Chinese CAPD patients. METHODS: The patients (receiving CAPD 3 months and more) in our center were investigated from January 1, 2008 to December 31, 2009. Multi-frequency bioelectrical impedance analysis was used to assess the patient's body composition and fluid status. RESULTS: A total of 307 CAPD patients (43% male, mean age 47.8±15.3 years) were enrolled, with a median duration of PD 14.6 (5.9-30.9) months. Fluid overload (defined by Extracellular water/Total body water (ECW/TBW)≥0.40) was present in 205 (66.8%) patients. Univariate analysis indicated that ECW/TBW were inversely associated with body mass index (r = -0.11, P = 0.047), subjective global assessment score (r = -0.11, P = 0.004), body fat mass (r = -0.15, P = 0.05), serum albumin (r = -0.32, P<0.001), creatinine (r = -0.14, P = 0.02), potassium (r = -0.15, P = 0.02), and residual urine output (r = -0.14, P = 0.01), positively associated with age (r = 0.27, P<0.001), Chalrlson Comorbidity Index score (r = 0.29, P<0.001), and systolic blood pressure (r = 0.22, P<0.001). Multivariate linear regression showed that lower serum albumin (β = -0.223, P<0.001), lower body fat mass (β = -0.166, P = 0.033), old age (β = 0.268, P<0.001), higher systolic blood pressure (β = 0.16, P = 0.006), less residual urine output (β = -0.116, P = 0.042), and lower serum potassium (β = -0.126, P = 0.03) were independently associated with higher ECW/TBW. After 1 year of follow-up, the cardiac event rate was significantly higher in the patients with fluid overload (17.1% vs 6.9%, P = 0.023) than that of the normal hydrated patients. CONCLUSIONS: The prevalence of fluid overload was high in CAPD patients. Fluid overload in CAPD patients were independently associated with protein-energy wasting, old age, and decreased residual urine output. Furthermore, CAPD patients with fluid overload had higher cardiac event rate than that of normal hydrated patents. |
| first_indexed | 2024-04-12T21:27:45Z |
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| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-04-12T21:27:45Z |
| publishDate | 2013-01-01 |
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| spelling | doaj.art-38fd5585215d4bada1a1867b1d1431732022-12-22T03:16:07ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0181e5329410.1371/journal.pone.0053294Prevalence and risk factors of fluid overload in Southern Chinese continuous ambulatory peritoneal dialysis patients.Qunying GuoChunyan YiJianying LiXiaofeng WuXiao YangXueqing YuBACKGROUND: Fluid overload is frequently present in CAPD patients and one of important predictors of mortality. The aim of this study is to investigate the prevalence and associated risk factors in a cohort study of Southern Chinese CAPD patients. METHODS: The patients (receiving CAPD 3 months and more) in our center were investigated from January 1, 2008 to December 31, 2009. Multi-frequency bioelectrical impedance analysis was used to assess the patient's body composition and fluid status. RESULTS: A total of 307 CAPD patients (43% male, mean age 47.8±15.3 years) were enrolled, with a median duration of PD 14.6 (5.9-30.9) months. Fluid overload (defined by Extracellular water/Total body water (ECW/TBW)≥0.40) was present in 205 (66.8%) patients. Univariate analysis indicated that ECW/TBW were inversely associated with body mass index (r = -0.11, P = 0.047), subjective global assessment score (r = -0.11, P = 0.004), body fat mass (r = -0.15, P = 0.05), serum albumin (r = -0.32, P<0.001), creatinine (r = -0.14, P = 0.02), potassium (r = -0.15, P = 0.02), and residual urine output (r = -0.14, P = 0.01), positively associated with age (r = 0.27, P<0.001), Chalrlson Comorbidity Index score (r = 0.29, P<0.001), and systolic blood pressure (r = 0.22, P<0.001). Multivariate linear regression showed that lower serum albumin (β = -0.223, P<0.001), lower body fat mass (β = -0.166, P = 0.033), old age (β = 0.268, P<0.001), higher systolic blood pressure (β = 0.16, P = 0.006), less residual urine output (β = -0.116, P = 0.042), and lower serum potassium (β = -0.126, P = 0.03) were independently associated with higher ECW/TBW. After 1 year of follow-up, the cardiac event rate was significantly higher in the patients with fluid overload (17.1% vs 6.9%, P = 0.023) than that of the normal hydrated patients. CONCLUSIONS: The prevalence of fluid overload was high in CAPD patients. Fluid overload in CAPD patients were independently associated with protein-energy wasting, old age, and decreased residual urine output. Furthermore, CAPD patients with fluid overload had higher cardiac event rate than that of normal hydrated patents.http://europepmc.org/articles/PMC3544813?pdf=render |
| spellingShingle | Qunying Guo Chunyan Yi Jianying Li Xiaofeng Wu Xiao Yang Xueqing Yu Prevalence and risk factors of fluid overload in Southern Chinese continuous ambulatory peritoneal dialysis patients. PLoS ONE |
| title | Prevalence and risk factors of fluid overload in Southern Chinese continuous ambulatory peritoneal dialysis patients. |
| title_full | Prevalence and risk factors of fluid overload in Southern Chinese continuous ambulatory peritoneal dialysis patients. |
| title_fullStr | Prevalence and risk factors of fluid overload in Southern Chinese continuous ambulatory peritoneal dialysis patients. |
| title_full_unstemmed | Prevalence and risk factors of fluid overload in Southern Chinese continuous ambulatory peritoneal dialysis patients. |
| title_short | Prevalence and risk factors of fluid overload in Southern Chinese continuous ambulatory peritoneal dialysis patients. |
| title_sort | prevalence and risk factors of fluid overload in southern chinese continuous ambulatory peritoneal dialysis patients |
| url | http://europepmc.org/articles/PMC3544813?pdf=render |
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