Equine Melanocytic Tumors: A Narrative Review
Adult grey horses have a high incidence of melanocytic tumors. This article narratively reviews the role of some genetic features related to melanoma formation in horses, such as STX17 mutation, ASIP or MITF alterations, and the link between the graying process and the development of these tumors. A...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/13/2/247 |
| _version_ | 1797447027091570688 |
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| author | José Pimenta Justina Prada Mário Cotovio |
| author_facet | José Pimenta Justina Prada Mário Cotovio |
| author_sort | José Pimenta |
| collection | DOAJ |
| description | Adult grey horses have a high incidence of melanocytic tumors. This article narratively reviews the role of some genetic features related to melanoma formation in horses, such as STX17 mutation, ASIP or MITF alterations, and the link between the graying process and the development of these tumors. A clear system of clinical and pathological classification of melanocytic tumors in naevus, dermal melanoma, dermal melanomatosis and anaplastic malignant melanoma is provided. Clinical and laboratorial methods of diagnosing are listed, with fine needle aspiration and histopathology being the most relevant. Relevance is given to immunohistochemistry, describing potentially important diagnostic biomarkers such as RACK1 and PNL2. Different therapeutical options available for equine practitioners are mentioned, with surgery, chemotherapy and electroporation being the most common. This article also elucidatesnew fields of research, perspectives, and new therapeutic targets, such as CD47, PD-1 and COX-2 biomarkers. |
| first_indexed | 2024-03-09T13:48:54Z |
| format | Article |
| id | doaj.art-38ff4cbcd058453daacce79d778c5d98 |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-09T13:48:54Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-38ff4cbcd058453daacce79d778c5d982023-11-30T20:53:15ZengMDPI AGAnimals2076-26152023-01-0113224710.3390/ani13020247Equine Melanocytic Tumors: A Narrative ReviewJosé Pimenta0Justina Prada1Mário Cotovio2Veterinary Sciencies Department, University of Trás-os-Montes e Alto Douro, 5000-801 Vila Real, PortugalVeterinary Sciencies Department, University of Trás-os-Montes e Alto Douro, 5000-801 Vila Real, PortugalVeterinary Sciencies Department, University of Trás-os-Montes e Alto Douro, 5000-801 Vila Real, PortugalAdult grey horses have a high incidence of melanocytic tumors. This article narratively reviews the role of some genetic features related to melanoma formation in horses, such as STX17 mutation, ASIP or MITF alterations, and the link between the graying process and the development of these tumors. A clear system of clinical and pathological classification of melanocytic tumors in naevus, dermal melanoma, dermal melanomatosis and anaplastic malignant melanoma is provided. Clinical and laboratorial methods of diagnosing are listed, with fine needle aspiration and histopathology being the most relevant. Relevance is given to immunohistochemistry, describing potentially important diagnostic biomarkers such as RACK1 and PNL2. Different therapeutical options available for equine practitioners are mentioned, with surgery, chemotherapy and electroporation being the most common. This article also elucidatesnew fields of research, perspectives, and new therapeutic targets, such as CD47, PD-1 and COX-2 biomarkers.https://www.mdpi.com/2076-2615/13/2/247equinemelanocytic tumorscutaneous neoplasia |
| spellingShingle | José Pimenta Justina Prada Mário Cotovio Equine Melanocytic Tumors: A Narrative Review Animals equine melanocytic tumors cutaneous neoplasia |
| title | Equine Melanocytic Tumors: A Narrative Review |
| title_full | Equine Melanocytic Tumors: A Narrative Review |
| title_fullStr | Equine Melanocytic Tumors: A Narrative Review |
| title_full_unstemmed | Equine Melanocytic Tumors: A Narrative Review |
| title_short | Equine Melanocytic Tumors: A Narrative Review |
| title_sort | equine melanocytic tumors a narrative review |
| topic | equine melanocytic tumors cutaneous neoplasia |
| url | https://www.mdpi.com/2076-2615/13/2/247 |
| work_keys_str_mv | AT josepimenta equinemelanocytictumorsanarrativereview AT justinaprada equinemelanocytictumorsanarrativereview AT mariocotovio equinemelanocytictumorsanarrativereview |