Caffeine, Is it effective for prevention of postdural puncture headache in young adult patients?
Background and objectives: Postdural puncture headache is a relatively common complication in spinal anesthesia, so several kinds of regimens have been suggested for treatment of this problem. The aim of this study was to evaluate the efficacy and safety of prophylactic administration of intravenous...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2014-04-01
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| Series: | Egyptian Journal of Anaesthesia |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1110184913001207 |
| _version_ | 1828176484613750784 |
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| author | Ashraf Ragab Khalid Noman Facharzt |
| author_facet | Ashraf Ragab Khalid Noman Facharzt |
| author_sort | Ashraf Ragab |
| collection | DOAJ |
| description | Background and objectives: Postdural puncture headache is a relatively common complication in spinal anesthesia, so several kinds of regimens have been suggested for treatment of this problem. The aim of this study was to evaluate the efficacy and safety of prophylactic administration of intravenous caffeine sodium benzoate for prevention of postdural puncture headache (PDPH) in young adult patients received spinal anesthesia.
Methods: One hundred ASA I and II patients undergoing elective knee surgeries either arthroscopy or anterior cruciate ligament reconstruction (ACL reconstruction) were included in this study. Patients were randomized by double-blind, placebo-controlled design to receive intravenously (IV) either 10 mL normal saline as control group (group S) or 10 ml with 500 mg caffeine sodium benzoate (CSB) as caffeine group (group C) during the first 60 min after spinal anesthesia administration. The patient’s electrocardiogram, noninvasive blood pressure, and pulse oximetry were monitored and recorded. The patients’ headaches were evaluated by using the visual analog scale (VAS), and the severity of the headache was classified as follows: no headache = 0, mild headache ⩽3, moderate headache from 4 to 6 and severe headache ⩾7. Analgesic requirements were recorded.
Results: Visual analog scale scores were significantly lower in group C than in group S. The incidence of moderate and severe headache was significantly higher in group S (11 patients) when compared with group C (2 patients). Analgesic demand was significantly lower in group C than in group S.
Conclusion: It seems that the incidence of postdural puncture headache decreases in those patients who received caffeine sodium benzoate. The article can potentially help clinicians to use caffeine as an effective drug for prevention of PDPH. |
| first_indexed | 2024-04-12T04:45:36Z |
| format | Article |
| id | doaj.art-38ff798ea51e43f5a8820bdbf20f5919 |
| institution | Directory Open Access Journal |
| issn | 1110-1849 |
| language | English |
| last_indexed | 2024-04-12T04:45:36Z |
| publishDate | 2014-04-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Egyptian Journal of Anaesthesia |
| spelling | doaj.art-38ff798ea51e43f5a8820bdbf20f59192022-12-22T03:47:30ZengTaylor & Francis GroupEgyptian Journal of Anaesthesia1110-18492014-04-0130218118610.1016/j.egja.2013.11.005Caffeine, Is it effective for prevention of postdural puncture headache in young adult patients?Ashraf Ragab0Khalid Noman Facharzt1Assistant Professor of Anesthesia, Faculty of Medicine, Cairo University, EgyptConsultant Orthopedic Surgeon, New Jeddah Clinic Hospital, Saudi ArabiaBackground and objectives: Postdural puncture headache is a relatively common complication in spinal anesthesia, so several kinds of regimens have been suggested for treatment of this problem. The aim of this study was to evaluate the efficacy and safety of prophylactic administration of intravenous caffeine sodium benzoate for prevention of postdural puncture headache (PDPH) in young adult patients received spinal anesthesia. Methods: One hundred ASA I and II patients undergoing elective knee surgeries either arthroscopy or anterior cruciate ligament reconstruction (ACL reconstruction) were included in this study. Patients were randomized by double-blind, placebo-controlled design to receive intravenously (IV) either 10 mL normal saline as control group (group S) or 10 ml with 500 mg caffeine sodium benzoate (CSB) as caffeine group (group C) during the first 60 min after spinal anesthesia administration. The patient’s electrocardiogram, noninvasive blood pressure, and pulse oximetry were monitored and recorded. The patients’ headaches were evaluated by using the visual analog scale (VAS), and the severity of the headache was classified as follows: no headache = 0, mild headache ⩽3, moderate headache from 4 to 6 and severe headache ⩾7. Analgesic requirements were recorded. Results: Visual analog scale scores were significantly lower in group C than in group S. The incidence of moderate and severe headache was significantly higher in group S (11 patients) when compared with group C (2 patients). Analgesic demand was significantly lower in group C than in group S. Conclusion: It seems that the incidence of postdural puncture headache decreases in those patients who received caffeine sodium benzoate. The article can potentially help clinicians to use caffeine as an effective drug for prevention of PDPH.http://www.sciencedirect.com/science/article/pii/S1110184913001207Spinal anesthesiaCaffeinePostdural puncture headacheKnee arthroplasty |
| spellingShingle | Ashraf Ragab Khalid Noman Facharzt Caffeine, Is it effective for prevention of postdural puncture headache in young adult patients? Egyptian Journal of Anaesthesia Spinal anesthesia Caffeine Postdural puncture headache Knee arthroplasty |
| title | Caffeine, Is it effective for prevention of postdural puncture headache in young adult patients? |
| title_full | Caffeine, Is it effective for prevention of postdural puncture headache in young adult patients? |
| title_fullStr | Caffeine, Is it effective for prevention of postdural puncture headache in young adult patients? |
| title_full_unstemmed | Caffeine, Is it effective for prevention of postdural puncture headache in young adult patients? |
| title_short | Caffeine, Is it effective for prevention of postdural puncture headache in young adult patients? |
| title_sort | caffeine is it effective for prevention of postdural puncture headache in young adult patients |
| topic | Spinal anesthesia Caffeine Postdural puncture headache Knee arthroplasty |
| url | http://www.sciencedirect.com/science/article/pii/S1110184913001207 |
| work_keys_str_mv | AT ashrafragab caffeineisiteffectiveforpreventionofpostduralpunctureheadacheinyoungadultpatients AT khalidnomanfacharzt caffeineisiteffectiveforpreventionofpostduralpunctureheadacheinyoungadultpatients |