Gender-related differences in the morphometry of the corpus callosum: MRI study
Background: The size and shape of the adult corpus callosum (CC) may vary with gender. There is, however, less literature available on data involving the morphometry of CC among the Indian population. Aims and Objectives: To measure the size of CC using magnetic resonance imaging (MRI) scans of n...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Manipal College of Medical Sciences, Pokhara
2023-09-01
|
| Series: | Asian Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/53502 |
| _version_ | 1797728886165864448 |
|---|---|
| author | Garima Sehgal Anupam Kumar Navneet Kumar Nikhil Aggarwal |
| author_facet | Garima Sehgal Anupam Kumar Navneet Kumar Nikhil Aggarwal |
| author_sort | Garima Sehgal |
| collection | DOAJ |
| description | Background: The size and shape of the adult corpus callosum (CC) may vary with gender. There is, however, less literature available on data involving the morphometry of CC among the Indian population.
Aims and Objectives: To measure the size of CC using magnetic resonance imaging (MRI) scans of normal Indian adult females and males and identify gender-related differences, if any.
Materials and Methods: The dimensions of CC were measured on MRI scans on a midsagittal section view belonging to 150 (59 females, 91 males) normal Indian adults (North India) using e-measurement tools. The measurements included the maximum length and height of CC, the thickness of various parts of CC, the CC index (CCI), and the distance of CC from the frontal and occipital poles of the cerebral hemisphere. The study was carried out in the Department of Anatomy in collaboration with the Department of Radiodiagnosis, King George’s Medical University, U.P., Lucknow, India. The data was analyzed using the statistical package for social sciences, 23rd version. Means were compared for significant differences using the independent unpaired t-test.
Results: The mean length of the CC was found to be 6.94±0.63 cm; mean height was 2.57±0.43 cm; the mean thickness of the genu was 9.16±2.26 mm; the mean thickness of the body was 5.09±0.99 mm; the mean thickness of splenium was 9.10±2.22 mm; the mean distance from the frontal pole was 3.66±0.35 cm; the mean distance from the occipital pole was 5.70±0.74 cm; and the mean CCI calculations showed to be 3.37±0.56. All measurements were found to be greater in males as compared to females except mean height (males 2.56±0.47 cm; females 2.59±0.37 cm) and mean thickness of the body (males 5.04±0.94 mm; females 5.17±1.06 mm). A statistically significant difference was observed in the distance of CC from the frontal pole in our population with respect to gender (P=0.03).
Conclusion: Based on observations made in the study, normative data of CC measurements was generated, and it was found that there was no significant gender-related difference in the morphology of CC; the only significant difference was in the distance of the genu from the frontal pole, which was greater in females as compared to males. |
| first_indexed | 2024-03-12T11:20:31Z |
| format | Article |
| id | doaj.art-390014d521a04db29eaa65ba26e97aa7 |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-03-12T11:20:31Z |
| publishDate | 2023-09-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-390014d521a04db29eaa65ba26e97aa72023-09-01T23:27:37ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762023-09-01149914https://doi.org/10.3126/ajms.v14i9.53502Gender-related differences in the morphometry of the corpus callosum: MRI studyGarima Sehgal 0https://orcid.org/0000-0002-4987-5487Anupam Kumar 1https://orcid.org/0009-0001-7177-4228Navneet Kumar 2https://orcid.org/0000-0002-8960-3531Nikhil Aggarwal 3https://orcid.org/0000-0002-4653-7060Professor (Junior Grade), Department of Anatomy, King George’s Medical University, Lucknow, Uttar Pradesh, India Junior Resident, Department of Medicine, King George’s Medical University, Lucknow, Uttar Pradesh, India Principal, Department of Anatomy, Autonomous State Medical College, Etah, Uttar Pradesh, India Senior Resident, Department of Anatomy, King George’s Medical University, Lucknow, Uttar Pradesh, India Background: The size and shape of the adult corpus callosum (CC) may vary with gender. There is, however, less literature available on data involving the morphometry of CC among the Indian population. Aims and Objectives: To measure the size of CC using magnetic resonance imaging (MRI) scans of normal Indian adult females and males and identify gender-related differences, if any. Materials and Methods: The dimensions of CC were measured on MRI scans on a midsagittal section view belonging to 150 (59 females, 91 males) normal Indian adults (North India) using e-measurement tools. The measurements included the maximum length and height of CC, the thickness of various parts of CC, the CC index (CCI), and the distance of CC from the frontal and occipital poles of the cerebral hemisphere. The study was carried out in the Department of Anatomy in collaboration with the Department of Radiodiagnosis, King George’s Medical University, U.P., Lucknow, India. The data was analyzed using the statistical package for social sciences, 23rd version. Means were compared for significant differences using the independent unpaired t-test. Results: The mean length of the CC was found to be 6.94±0.63 cm; mean height was 2.57±0.43 cm; the mean thickness of the genu was 9.16±2.26 mm; the mean thickness of the body was 5.09±0.99 mm; the mean thickness of splenium was 9.10±2.22 mm; the mean distance from the frontal pole was 3.66±0.35 cm; the mean distance from the occipital pole was 5.70±0.74 cm; and the mean CCI calculations showed to be 3.37±0.56. All measurements were found to be greater in males as compared to females except mean height (males 2.56±0.47 cm; females 2.59±0.37 cm) and mean thickness of the body (males 5.04±0.94 mm; females 5.17±1.06 mm). A statistically significant difference was observed in the distance of CC from the frontal pole in our population with respect to gender (P=0.03). Conclusion: Based on observations made in the study, normative data of CC measurements was generated, and it was found that there was no significant gender-related difference in the morphology of CC; the only significant difference was in the distance of the genu from the frontal pole, which was greater in females as compared to males.https://www.nepjol.info/index.php/AJMS/article/view/53502magnetic resonance imaging; morphometry; corpus callosum; cerebral hemisphere |
| spellingShingle | Garima Sehgal Anupam Kumar Navneet Kumar Nikhil Aggarwal Gender-related differences in the morphometry of the corpus callosum: MRI study Asian Journal of Medical Sciences magnetic resonance imaging; morphometry; corpus callosum; cerebral hemisphere |
| title | Gender-related differences in the morphometry of the corpus callosum: MRI study |
| title_full | Gender-related differences in the morphometry of the corpus callosum: MRI study |
| title_fullStr | Gender-related differences in the morphometry of the corpus callosum: MRI study |
| title_full_unstemmed | Gender-related differences in the morphometry of the corpus callosum: MRI study |
| title_short | Gender-related differences in the morphometry of the corpus callosum: MRI study |
| title_sort | gender related differences in the morphometry of the corpus callosum mri study |
| topic | magnetic resonance imaging; morphometry; corpus callosum; cerebral hemisphere |
| url | https://www.nepjol.info/index.php/AJMS/article/view/53502 |
| work_keys_str_mv | AT garimasehgal genderrelateddifferencesinthemorphometryofthecorpuscallosummristudy AT anupamkumar genderrelateddifferencesinthemorphometryofthecorpuscallosummristudy AT navneetkumar genderrelateddifferencesinthemorphometryofthecorpuscallosummristudy AT nikhilaggarwal genderrelateddifferencesinthemorphometryofthecorpuscallosummristudy |