Does [18F]F-FDG-PET/MRI add metabolic information to magnetic resonance image in childhood-onset Takayasu’s arteritis patients? A multicenter case series
Abstract Background The observation that 2-deoxy-2[18F]fluoro-D-glucose-positron emission tomography/magnetic resonance imaging ([18F]F-FDG-PET/MRI) revealed high-grade arterial wall FDG uptake, without arterial wall thickening with contrast-enhancement, in a considerable number of c-TA patients in...
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| Format: | Article |
| Language: | English |
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BMC
2022-07-01
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| Series: | Advances in Rheumatology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s42358-022-00260-5 |
| _version_ | 1818162981523947520 |
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| author | Gleice Clemente Alexandre W. de Souza Hilton Leão Filho Fernando M. A. Coelho Carlos Buchpiguel Marcos Lima Camila Carneiro Rosa M. R. Pereira Nadia Aikawa Clovis A. Silva Lucia M. A. Campos Gabriel Alves Camilla Astley Bruno Gualano Maria Teresa Terreri |
| author_facet | Gleice Clemente Alexandre W. de Souza Hilton Leão Filho Fernando M. A. Coelho Carlos Buchpiguel Marcos Lima Camila Carneiro Rosa M. R. Pereira Nadia Aikawa Clovis A. Silva Lucia M. A. Campos Gabriel Alves Camilla Astley Bruno Gualano Maria Teresa Terreri |
| author_sort | Gleice Clemente |
| collection | DOAJ |
| description | Abstract Background The observation that 2-deoxy-2[18F]fluoro-D-glucose-positron emission tomography/magnetic resonance imaging ([18F]F-FDG-PET/MRI) revealed high-grade arterial wall FDG uptake, without arterial wall thickening with contrast-enhancement, in a considerable number of c-TA patients in our previous study, encouraged us to compare patients with both PET and MR angiography (MRA) positives, with those with PET positive but MRA negative. Our aim was to evaluate the relevance of these two imaging modalities together. Methods A three-center cross-sectional study with 17 patients who fulfilled the EULAR/PRINTO/PReS criteria for c-TA and who underwent [18F]F-FDG-PET/MRI was previously performed. Herein we compared patients/vessels with positive PET (arterial wall 18F-FDG uptake higher than liver) and positive MRA (arterial wall thickening with contrast-enhancement)—group 1, with those with positive PET but negative MRA—group 2. Results Median disease duration of 17 c-TA patients was 10.4 years. Nine patients were classified as group 1 and six as group 2. Median of metabolic inflammatory volume (MIV) of all arterial segments was significantly higher in group 1 (2346 vs. 1177 cm3; p = 0.036). Fifty-four (19%) from 284 available arterial segments presented positive findings in vessel wall in one or both images. Positive findings were concordant between PET and MRA in only 13% arterial segments (group 1); most changes (28–59.6%) that were discordant between both images, were positive in PET and negative in MRA (group 2). Conclusion Our study demonstrated that [18F]F-FDG-PET/MRI added information about inflammation in vessel wall of c-TA patients. Prospective multicenter studies are needed in order to get solid data to guide immunosuppressive tapering and withdrawal. |
| first_indexed | 2024-12-11T16:42:18Z |
| format | Article |
| id | doaj.art-39003ff2e49c4405b784c3a5c1aea3ad |
| institution | Directory Open Access Journal |
| issn | 2523-3106 |
| language | English |
| last_indexed | 2024-12-11T16:42:18Z |
| publishDate | 2022-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Advances in Rheumatology |
| spelling | doaj.art-39003ff2e49c4405b784c3a5c1aea3ad2022-12-22T00:58:17ZengBMCAdvances in Rheumatology2523-31062022-07-016211710.1186/s42358-022-00260-5Does [18F]F-FDG-PET/MRI add metabolic information to magnetic resonance image in childhood-onset Takayasu’s arteritis patients? A multicenter case seriesGleice Clemente0Alexandre W. de Souza1Hilton Leão Filho2Fernando M. A. Coelho3Carlos Buchpiguel4Marcos Lima5Camila Carneiro6Rosa M. R. Pereira7Nadia Aikawa8Clovis A. Silva9Lucia M. A. Campos10Gabriel Alves11Camilla Astley12Bruno Gualano13Maria Teresa Terreri14Paediatric Rheumatology Unit, Paediatrics Department, Universidade Federal de Sao PauloDivision of Rheumatology, Department of Medicine, Universidade Federal de Sao PauloRadiology Institute, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de Sao PauloRadiology Institute, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de Sao PauloNuclear Medicine LIM-43, Department of Radiology and Oncology, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de Sao PauloNuclear Medicine LIM-43, Department of Radiology and Oncology, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de Sao PauloNuclear Medicine LIM-43, Department of Radiology and Oncology, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de Sao PauloDivision of Rheumatology, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de Sao PauloDivision of Rheumatology, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de Sao PauloChildren’s Institute, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de Sao PauloChildren’s Institute, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de Sao PauloUniversidade Federal de Sao PauloDivision of Rheumatology, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de Sao PauloDivision of Rheumatology, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de Sao PauloPaediatric Rheumatology Unit, Paediatrics Department, Universidade Federal de Sao PauloAbstract Background The observation that 2-deoxy-2[18F]fluoro-D-glucose-positron emission tomography/magnetic resonance imaging ([18F]F-FDG-PET/MRI) revealed high-grade arterial wall FDG uptake, without arterial wall thickening with contrast-enhancement, in a considerable number of c-TA patients in our previous study, encouraged us to compare patients with both PET and MR angiography (MRA) positives, with those with PET positive but MRA negative. Our aim was to evaluate the relevance of these two imaging modalities together. Methods A three-center cross-sectional study with 17 patients who fulfilled the EULAR/PRINTO/PReS criteria for c-TA and who underwent [18F]F-FDG-PET/MRI was previously performed. Herein we compared patients/vessels with positive PET (arterial wall 18F-FDG uptake higher than liver) and positive MRA (arterial wall thickening with contrast-enhancement)—group 1, with those with positive PET but negative MRA—group 2. Results Median disease duration of 17 c-TA patients was 10.4 years. Nine patients were classified as group 1 and six as group 2. Median of metabolic inflammatory volume (MIV) of all arterial segments was significantly higher in group 1 (2346 vs. 1177 cm3; p = 0.036). Fifty-four (19%) from 284 available arterial segments presented positive findings in vessel wall in one or both images. Positive findings were concordant between PET and MRA in only 13% arterial segments (group 1); most changes (28–59.6%) that were discordant between both images, were positive in PET and negative in MRA (group 2). Conclusion Our study demonstrated that [18F]F-FDG-PET/MRI added information about inflammation in vessel wall of c-TA patients. Prospective multicenter studies are needed in order to get solid data to guide immunosuppressive tapering and withdrawal.https://doi.org/10.1186/s42358-022-00260-5Takayasu arteritisVasculitisPETPET/MRIChildrenAdolescents |
| spellingShingle | Gleice Clemente Alexandre W. de Souza Hilton Leão Filho Fernando M. A. Coelho Carlos Buchpiguel Marcos Lima Camila Carneiro Rosa M. R. Pereira Nadia Aikawa Clovis A. Silva Lucia M. A. Campos Gabriel Alves Camilla Astley Bruno Gualano Maria Teresa Terreri Does [18F]F-FDG-PET/MRI add metabolic information to magnetic resonance image in childhood-onset Takayasu’s arteritis patients? A multicenter case series Advances in Rheumatology Takayasu arteritis Vasculitis PET PET/MRI Children Adolescents |
| title | Does [18F]F-FDG-PET/MRI add metabolic information to magnetic resonance image in childhood-onset Takayasu’s arteritis patients? A multicenter case series |
| title_full | Does [18F]F-FDG-PET/MRI add metabolic information to magnetic resonance image in childhood-onset Takayasu’s arteritis patients? A multicenter case series |
| title_fullStr | Does [18F]F-FDG-PET/MRI add metabolic information to magnetic resonance image in childhood-onset Takayasu’s arteritis patients? A multicenter case series |
| title_full_unstemmed | Does [18F]F-FDG-PET/MRI add metabolic information to magnetic resonance image in childhood-onset Takayasu’s arteritis patients? A multicenter case series |
| title_short | Does [18F]F-FDG-PET/MRI add metabolic information to magnetic resonance image in childhood-onset Takayasu’s arteritis patients? A multicenter case series |
| title_sort | does 18f f fdg pet mri add metabolic information to magnetic resonance image in childhood onset takayasu s arteritis patients a multicenter case series |
| topic | Takayasu arteritis Vasculitis PET PET/MRI Children Adolescents |
| url | https://doi.org/10.1186/s42358-022-00260-5 |
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