To what extent do sexual hormones influence bipolar disorder?
Introduction It is known that female reproductive events and hormonal treatments can impact the course of bipolar disorder (BD) in women, some of whom are more vulnerable to the development of mood instability under periods of hormonal fluctuation. The mechanisms involved are, however, largely unk...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2021-04-01
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| Series: | European Psychiatry |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933821016503/type/journal_article |
| _version_ | 1797616491866095616 |
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| author | F. Gonçalves Viegas F. Ferreira I. Figueiredo A. Lourenço |
| author_facet | F. Gonçalves Viegas F. Ferreira I. Figueiredo A. Lourenço |
| author_sort | F. Gonçalves Viegas |
| collection | DOAJ |
| description |
Introduction
It is known that female reproductive events and hormonal treatments can impact the course of bipolar disorder (BD) in women, some of whom are more vulnerable to the development of mood instability under periods of hormonal fluctuation. The mechanisms involved are, however, largely unknown. The aim of this work is to review the impact of sexual hormones on the course of BD, regarding a clinical case.
Objectives
To explore the role of sexual hormones in BD.
Methods
Literature review using Medline database.
Results
This is a case of a 36-year-old woman with type 1 BD who develops a manic episode after starting oral contraception (OC). This episode remitted with suspension of the pill. Estrogen and progesterone are involved in various aspects of brain function, such as brain development, synaptic plasticity, and modulation of neurotransmitter systems. Studies indicate that there is a relationship between ovarian hormones and intracellular signaling systems involved in the pathophysiology of BD. However, research on OC use in patients with mood disorders is limited. Recent studies state that OC aren’t associated with a worse clinical course and don’t negatively influence BD, while other studies show there is a subgroup of bipolar women that improve with hormonal stability, while others get worse.
Conclusions
Further studies are needed to determine possible relationships between sexual hormones and BD, and it is essential to identify patients vulnerable to these risks by measuring baseline hormone levels, assessing hormone sensitivity through a history of mood changes during menstrual cycle and a history of previous mental health problems.
Disclosure
No significant relationships.
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| first_indexed | 2024-03-11T07:41:57Z |
| format | Article |
| id | doaj.art-3900f14b5f5f48cabc37ea4f009d6f5c |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:41:57Z |
| publishDate | 2021-04-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-3900f14b5f5f48cabc37ea4f009d6f5c2023-11-17T05:08:21ZengCambridge University PressEuropean Psychiatry0924-93381778-35852021-04-0164S621S62110.1192/j.eurpsy.2021.1650To what extent do sexual hormones influence bipolar disorder?F. Gonçalves Viegas0F. Ferreira1I. Figueiredo2A. Lourenço3Departamento De Saúde Mental, Hospital Prof Dr Fernando Fonseca, Amadora, PortugalDepartamento De Saúde Mental, Hospital Prof Dr Fernando Fonseca, Amadora, PortugalDepartamento De Saúde Mental, Hospital Prof Dr Fernando Fonseca, Amadora, PortugalDepartamento De Saúde Mental, Hospital Prof Dr Fernando Fonseca, Amadora, Portugal Introduction It is known that female reproductive events and hormonal treatments can impact the course of bipolar disorder (BD) in women, some of whom are more vulnerable to the development of mood instability under periods of hormonal fluctuation. The mechanisms involved are, however, largely unknown. The aim of this work is to review the impact of sexual hormones on the course of BD, regarding a clinical case. Objectives To explore the role of sexual hormones in BD. Methods Literature review using Medline database. Results This is a case of a 36-year-old woman with type 1 BD who develops a manic episode after starting oral contraception (OC). This episode remitted with suspension of the pill. Estrogen and progesterone are involved in various aspects of brain function, such as brain development, synaptic plasticity, and modulation of neurotransmitter systems. Studies indicate that there is a relationship between ovarian hormones and intracellular signaling systems involved in the pathophysiology of BD. However, research on OC use in patients with mood disorders is limited. Recent studies state that OC aren’t associated with a worse clinical course and don’t negatively influence BD, while other studies show there is a subgroup of bipolar women that improve with hormonal stability, while others get worse. Conclusions Further studies are needed to determine possible relationships between sexual hormones and BD, and it is essential to identify patients vulnerable to these risks by measuring baseline hormone levels, assessing hormone sensitivity through a history of mood changes during menstrual cycle and a history of previous mental health problems. Disclosure No significant relationships. https://www.cambridge.org/core/product/identifier/S0924933821016503/type/journal_articlesexual hormonesoral contraceptionmood instabilitybipolar disorder |
| spellingShingle | F. Gonçalves Viegas F. Ferreira I. Figueiredo A. Lourenço To what extent do sexual hormones influence bipolar disorder? European Psychiatry sexual hormones oral contraception mood instability bipolar disorder |
| title | To what extent do sexual hormones influence bipolar disorder? |
| title_full | To what extent do sexual hormones influence bipolar disorder? |
| title_fullStr | To what extent do sexual hormones influence bipolar disorder? |
| title_full_unstemmed | To what extent do sexual hormones influence bipolar disorder? |
| title_short | To what extent do sexual hormones influence bipolar disorder? |
| title_sort | to what extent do sexual hormones influence bipolar disorder |
| topic | sexual hormones oral contraception mood instability bipolar disorder |
| url | https://www.cambridge.org/core/product/identifier/S0924933821016503/type/journal_article |
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