Brain mediators of negative affect-induced physical symptom reporting in patients with functional somatic syndromes
Abstract Functional somatic syndromes (FSS) include fibromyalgia, irritable bowel syndrome (IBS), and others. In FSS patients, merely viewing negative affective pictures can elicit increased physical symptoms. Our aim was to investigate the neural mechanisms underlying such negative affect-induced p...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2023-08-01
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| Series: | Translational Psychiatry |
| Online Access: | https://doi.org/10.1038/s41398-023-02567-3 |
| _version_ | 1797556220286992384 |
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| author | Katleen Bogaerts Maaike Van Den Houte Daniëlle Jongen Huynh Giao Ly Eline Coppens Koen Schruers Ilse Van Diest Tack Jan Peter Van Wambeke Bogdan Petre Philip A. Kragel Martin A. Lindquist Tor D. Wager Lukas Van Oudenhove Omer Van den Bergh |
| author_facet | Katleen Bogaerts Maaike Van Den Houte Daniëlle Jongen Huynh Giao Ly Eline Coppens Koen Schruers Ilse Van Diest Tack Jan Peter Van Wambeke Bogdan Petre Philip A. Kragel Martin A. Lindquist Tor D. Wager Lukas Van Oudenhove Omer Van den Bergh |
| author_sort | Katleen Bogaerts |
| collection | DOAJ |
| description | Abstract Functional somatic syndromes (FSS) include fibromyalgia, irritable bowel syndrome (IBS), and others. In FSS patients, merely viewing negative affective pictures can elicit increased physical symptoms. Our aim was to investigate the neural mechanisms underlying such negative affect-induced physical symptoms in FSS patients. Thirty patients with fibromyalgia and/or IBS and 30 healthy controls (all women) watched neutral, positive and negative affective picture blocks during functional MRI scanning and rated negative affect and physical symptoms after every block. We compared brain-wide activation during negative versus neutral picture viewing in FSS patients versus controls using robust general linear model analysis. Further, we compared neurologic pain signature (NPS), stimulus intensity-independent pain signature (SIIPS) and picture-induced negative emotion signature (PINES) responses to the negative versus neutral affect contrast and investigated whether they mediated between-group differences in affective picture-induced physical symptom reporting. More physical symptoms were reported after viewing negative compared to neutral pictures, and this effect was larger in patients than controls (p = 0.025). Accordingly, patients showed stronger activation in somatosensory regions during negative versus neutral picture viewing. NPS, but not SIIPS nor PINES, responses were higher in patients than controls during negative versus neutral pictures (p = 0.026). These differential NPS responses partially mediated between-group differences in physical symptoms. In conclusion, picture-induced negative affect elicits physical symptoms in FSS patients as a result of activation of somatosensory and nociceptive brain patterns, supporting the idea that affect-driven alterations in processing of somatic signals is a critical mechanism underlying FSS. |
| first_indexed | 2024-03-10T16:59:43Z |
| format | Article |
| id | doaj.art-3905c46b12b84754b35090537a5759eb |
| institution | Directory Open Access Journal |
| issn | 2158-3188 |
| language | English |
| last_indexed | 2024-03-10T16:59:43Z |
| publishDate | 2023-08-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Translational Psychiatry |
| spelling | doaj.art-3905c46b12b84754b35090537a5759eb2023-11-20T11:00:36ZengNature Publishing GroupTranslational Psychiatry2158-31882023-08-0113111110.1038/s41398-023-02567-3Brain mediators of negative affect-induced physical symptom reporting in patients with functional somatic syndromesKatleen Bogaerts0Maaike Van Den Houte1Daniëlle Jongen2Huynh Giao Ly3Eline Coppens4Koen Schruers5Ilse Van Diest6Tack Jan7Peter Van Wambeke8Bogdan Petre9Philip A. Kragel10Martin A. Lindquist11Tor D. Wager12Lukas Van Oudenhove13Omer Van den Bergh14REVAL - Rehabilitation Research Center, Faculty of Rehabilitation Sciences, Hasselt UniversityREVAL - Rehabilitation Research Center, Faculty of Rehabilitation Sciences, Hasselt UniversityLaboratory for Brain-Gut Axis Studies (LaBGAS), Translational Research Center for Gastrointestinal Disorders (TARGID), University of LeuvenLaboratory for Brain-Gut Axis Studies (LaBGAS), Translational Research Center for Gastrointestinal Disorders (TARGID), University of LeuvenUniversity Psychiatric Center KU Leuven, University Hospitals LeuvenMHeNS School for Mental Health and Neuroscience, Maastricht UniversityHealth Psychology, Psychology and Educational Sciences, University of LeuvenGI motility and sensitivity research group, Translational Research Center for Gastrointestinal Disorders (TARGID), University of LeuvenDepartment of Physical and Rehabilitation Medicine, University Hospitals LeuvenCognitive & Affective Neuroscience Lab (CANLab), Department of Psychological and Brain Sciences, Dartmouth CollegeDepartment of Psychology, Emory UniversityBiostatistics, Johns Hopkins School of Public HealthCognitive & Affective Neuroscience Lab (CANLab), Department of Psychological and Brain Sciences, Dartmouth CollegeLaboratory for Brain-Gut Axis Studies (LaBGAS), Translational Research Center for Gastrointestinal Disorders (TARGID), University of LeuvenHealth Psychology, Psychology and Educational Sciences, University of LeuvenAbstract Functional somatic syndromes (FSS) include fibromyalgia, irritable bowel syndrome (IBS), and others. In FSS patients, merely viewing negative affective pictures can elicit increased physical symptoms. Our aim was to investigate the neural mechanisms underlying such negative affect-induced physical symptoms in FSS patients. Thirty patients with fibromyalgia and/or IBS and 30 healthy controls (all women) watched neutral, positive and negative affective picture blocks during functional MRI scanning and rated negative affect and physical symptoms after every block. We compared brain-wide activation during negative versus neutral picture viewing in FSS patients versus controls using robust general linear model analysis. Further, we compared neurologic pain signature (NPS), stimulus intensity-independent pain signature (SIIPS) and picture-induced negative emotion signature (PINES) responses to the negative versus neutral affect contrast and investigated whether they mediated between-group differences in affective picture-induced physical symptom reporting. More physical symptoms were reported after viewing negative compared to neutral pictures, and this effect was larger in patients than controls (p = 0.025). Accordingly, patients showed stronger activation in somatosensory regions during negative versus neutral picture viewing. NPS, but not SIIPS nor PINES, responses were higher in patients than controls during negative versus neutral pictures (p = 0.026). These differential NPS responses partially mediated between-group differences in physical symptoms. In conclusion, picture-induced negative affect elicits physical symptoms in FSS patients as a result of activation of somatosensory and nociceptive brain patterns, supporting the idea that affect-driven alterations in processing of somatic signals is a critical mechanism underlying FSS.https://doi.org/10.1038/s41398-023-02567-3 |
| spellingShingle | Katleen Bogaerts Maaike Van Den Houte Daniëlle Jongen Huynh Giao Ly Eline Coppens Koen Schruers Ilse Van Diest Tack Jan Peter Van Wambeke Bogdan Petre Philip A. Kragel Martin A. Lindquist Tor D. Wager Lukas Van Oudenhove Omer Van den Bergh Brain mediators of negative affect-induced physical symptom reporting in patients with functional somatic syndromes Translational Psychiatry |
| title | Brain mediators of negative affect-induced physical symptom reporting in patients with functional somatic syndromes |
| title_full | Brain mediators of negative affect-induced physical symptom reporting in patients with functional somatic syndromes |
| title_fullStr | Brain mediators of negative affect-induced physical symptom reporting in patients with functional somatic syndromes |
| title_full_unstemmed | Brain mediators of negative affect-induced physical symptom reporting in patients with functional somatic syndromes |
| title_short | Brain mediators of negative affect-induced physical symptom reporting in patients with functional somatic syndromes |
| title_sort | brain mediators of negative affect induced physical symptom reporting in patients with functional somatic syndromes |
| url | https://doi.org/10.1038/s41398-023-02567-3 |
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