Synthesis and Characterization of Some O-[2-{''2Substituted Aryl (''1,''3,''4 thia diazolyl) ['3,'4-b]-'1,'2,'4- Triazolyl]-Ethyl]-p- chlorobenzald oxime Derivatives.
In this study new derivatives of O-[2-{''2-Substituted Aryl (''1,''3,''4 thia diazolyl) ['3,'4b]-'1,'2,'4- Triazolyl]-Ethyl]-p- chlorobenzald oxime (6-11) have been synthesized from the starting material p-chloro – E- benzaldoxime 1...
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| Format: | Article |
| Language: | English |
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University of Baghdad
2017-04-01
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| Series: | Ibn Al-Haitham Journal for Pure and Applied Sciences |
| Online Access: | https://jih.uobaghdad.edu.iq/index.php/j/article/view/343 |
| _version_ | 1818243959039721472 |
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| author | Eman M. Hussain |
| author_facet | Eman M. Hussain |
| author_sort | Eman M. Hussain |
| collection | DOAJ |
| description |
In this study new derivatives of O-[2-{''2-Substituted Aryl (''1,''3,''4 thia diazolyl) ['3,'4b]-'1,'2,'4- Triazolyl]-Ethyl]-p- chlorobenzald oxime (6-11) have been synthesized from the starting material p-chloro – E- benzaldoxime 1. Compound 2 was synthesized by the reaction of p-chloro – E- benzaldoxime with ethyl acrylate in basic medium. Refluxing compound 2 with hydrazine hydrate in ethanol absolute afforded 3. Derivative 4 was prepared by the reaction of 3 with carbon disulphide, treated of compound 4 with hydrazine hydrate gave 5. The derivatives (6-11) were prepared by the reaction of 5 with different substitutes of aromatic acids. The structures of these compounds were characterized from their melting points, infrared spectroscopy, elemental analysis and 1HNMR (some of them). Compounds (6-11) were exhibited biological activity against E- coli bacteria. Compound 9 exhibited higher degree of activity than the other. Key words:Synthesis of new derivatives of thiaduazol and triazol compounds
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| first_indexed | 2024-12-12T14:09:24Z |
| format | Article |
| id | doaj.art-39068dd35983461bace00234988db430 |
| institution | Directory Open Access Journal |
| issn | 1609-4042 2521-3407 |
| language | English |
| last_indexed | 2024-12-12T14:09:24Z |
| publishDate | 2017-04-01 |
| publisher | University of Baghdad |
| record_format | Article |
| series | Ibn Al-Haitham Journal for Pure and Applied Sciences |
| spelling | doaj.art-39068dd35983461bace00234988db4302022-12-22T00:22:08ZengUniversity of BaghdadIbn Al-Haitham Journal for Pure and Applied Sciences1609-40422521-34072017-04-01272Synthesis and Characterization of Some O-[2-{''2Substituted Aryl (''1,''3,''4 thia diazolyl) ['3,'4-b]-'1,'2,'4- Triazolyl]-Ethyl]-p- chlorobenzald oxime Derivatives.Eman M. Hussain In this study new derivatives of O-[2-{''2-Substituted Aryl (''1,''3,''4 thia diazolyl) ['3,'4b]-'1,'2,'4- Triazolyl]-Ethyl]-p- chlorobenzald oxime (6-11) have been synthesized from the starting material p-chloro – E- benzaldoxime 1. Compound 2 was synthesized by the reaction of p-chloro – E- benzaldoxime with ethyl acrylate in basic medium. Refluxing compound 2 with hydrazine hydrate in ethanol absolute afforded 3. Derivative 4 was prepared by the reaction of 3 with carbon disulphide, treated of compound 4 with hydrazine hydrate gave 5. The derivatives (6-11) were prepared by the reaction of 5 with different substitutes of aromatic acids. The structures of these compounds were characterized from their melting points, infrared spectroscopy, elemental analysis and 1HNMR (some of them). Compounds (6-11) were exhibited biological activity against E- coli bacteria. Compound 9 exhibited higher degree of activity than the other. Key words:Synthesis of new derivatives of thiaduazol and triazol compounds https://jih.uobaghdad.edu.iq/index.php/j/article/view/343 |
| spellingShingle | Eman M. Hussain Synthesis and Characterization of Some O-[2-{''2Substituted Aryl (''1,''3,''4 thia diazolyl) ['3,'4-b]-'1,'2,'4- Triazolyl]-Ethyl]-p- chlorobenzald oxime Derivatives. Ibn Al-Haitham Journal for Pure and Applied Sciences |
| title | Synthesis and Characterization of Some O-[2-{''2Substituted Aryl (''1,''3,''4 thia diazolyl) ['3,'4-b]-'1,'2,'4- Triazolyl]-Ethyl]-p- chlorobenzald oxime Derivatives. |
| title_full | Synthesis and Characterization of Some O-[2-{''2Substituted Aryl (''1,''3,''4 thia diazolyl) ['3,'4-b]-'1,'2,'4- Triazolyl]-Ethyl]-p- chlorobenzald oxime Derivatives. |
| title_fullStr | Synthesis and Characterization of Some O-[2-{''2Substituted Aryl (''1,''3,''4 thia diazolyl) ['3,'4-b]-'1,'2,'4- Triazolyl]-Ethyl]-p- chlorobenzald oxime Derivatives. |
| title_full_unstemmed | Synthesis and Characterization of Some O-[2-{''2Substituted Aryl (''1,''3,''4 thia diazolyl) ['3,'4-b]-'1,'2,'4- Triazolyl]-Ethyl]-p- chlorobenzald oxime Derivatives. |
| title_short | Synthesis and Characterization of Some O-[2-{''2Substituted Aryl (''1,''3,''4 thia diazolyl) ['3,'4-b]-'1,'2,'4- Triazolyl]-Ethyl]-p- chlorobenzald oxime Derivatives. |
| title_sort | synthesis and characterization of some o 2 2substituted aryl 1 3 4 thia diazolyl 3 4 b 1 2 4 triazolyl ethyl p chlorobenzald oxime derivatives |
| url | https://jih.uobaghdad.edu.iq/index.php/j/article/view/343 |
| work_keys_str_mv | AT emanmhussain synthesisandcharacterizationofsomeo22substitutedaryl134thiadiazolyl34b124triazolylethylpchlorobenzaldoximederivatives |