Mechanisms of infectivity and evasion derived from microvesicles cargo produced by Trypanosoma cruzi
Cell invasion by the intracellular protozoans requires interaction of proteins from both the host and the parasite. Many parasites establish chronic infections, showing they have the potential to escape the immune system; for example, Trypanosoma cruzi is an intracellular parasite that causes Chagas...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-11-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fcimb.2016.00161/full |
| _version_ | 1818339602634637312 |
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| author | Bruna Cristina Borges Isadora Akemi Uehara Laysa Oliveira Santos Dias Paula Cristina Brígido Claudio Vieira Silva Marcelo J B Silva |
| author_facet | Bruna Cristina Borges Isadora Akemi Uehara Laysa Oliveira Santos Dias Paula Cristina Brígido Claudio Vieira Silva Marcelo J B Silva |
| author_sort | Bruna Cristina Borges |
| collection | DOAJ |
| description | Cell invasion by the intracellular protozoans requires interaction of proteins from both the host and the parasite. Many parasites establish chronic infections, showing they have the potential to escape the immune system; for example, Trypanosoma cruzi is an intracellular parasite that causes Chagas disease. Parasite internalization into host cell requires secreted and surface molecules, such as microvesicles. The release of microvesicles and other vesicles, such as exosomes, by different eukaryotic organisms was first observed in the late 20th century. The characterization and function of these vesicles have recently been the focus of several investigations. In this review, we discuss the release of microvesicles by T. cruzi. The molecular content of these vesicles is composed of several molecules that take place during parasite-host cell interaction and contribute to the parasite-driven mechanism of evasion from the host immune system. These new findings appear to have a profound impact on the comprehension of T. cruzi biology and highlight novel potential strategies for developing more efficient therapeutic approaches. |
| first_indexed | 2024-12-13T15:29:37Z |
| format | Article |
| id | doaj.art-39071d7d0acb4b85b1fa63525aaaa0b2 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-13T15:29:37Z |
| publishDate | 2016-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-39071d7d0acb4b85b1fa63525aaaa0b22022-12-21T23:40:14ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882016-11-01610.3389/fcimb.2016.00161225070Mechanisms of infectivity and evasion derived from microvesicles cargo produced by Trypanosoma cruziBruna Cristina Borges0Isadora Akemi Uehara1Laysa Oliveira Santos Dias2Paula Cristina Brígido3Claudio Vieira Silva4Marcelo J B Silva5ResearcherResearcherResearcherResearcherResearcherResearcherCell invasion by the intracellular protozoans requires interaction of proteins from both the host and the parasite. Many parasites establish chronic infections, showing they have the potential to escape the immune system; for example, Trypanosoma cruzi is an intracellular parasite that causes Chagas disease. Parasite internalization into host cell requires secreted and surface molecules, such as microvesicles. The release of microvesicles and other vesicles, such as exosomes, by different eukaryotic organisms was first observed in the late 20th century. The characterization and function of these vesicles have recently been the focus of several investigations. In this review, we discuss the release of microvesicles by T. cruzi. The molecular content of these vesicles is composed of several molecules that take place during parasite-host cell interaction and contribute to the parasite-driven mechanism of evasion from the host immune system. These new findings appear to have a profound impact on the comprehension of T. cruzi biology and highlight novel potential strategies for developing more efficient therapeutic approaches.http://journal.frontiersin.org/Journal/10.3389/fcimb.2016.00161/fullExosomesTrypanosoma cruziMicrovesiclescell invasionCell evasion |
| spellingShingle | Bruna Cristina Borges Isadora Akemi Uehara Laysa Oliveira Santos Dias Paula Cristina Brígido Claudio Vieira Silva Marcelo J B Silva Mechanisms of infectivity and evasion derived from microvesicles cargo produced by Trypanosoma cruzi Frontiers in Cellular and Infection Microbiology Exosomes Trypanosoma cruzi Microvesicles cell invasion Cell evasion |
| title | Mechanisms of infectivity and evasion derived from microvesicles cargo produced by Trypanosoma cruzi |
| title_full | Mechanisms of infectivity and evasion derived from microvesicles cargo produced by Trypanosoma cruzi |
| title_fullStr | Mechanisms of infectivity and evasion derived from microvesicles cargo produced by Trypanosoma cruzi |
| title_full_unstemmed | Mechanisms of infectivity and evasion derived from microvesicles cargo produced by Trypanosoma cruzi |
| title_short | Mechanisms of infectivity and evasion derived from microvesicles cargo produced by Trypanosoma cruzi |
| title_sort | mechanisms of infectivity and evasion derived from microvesicles cargo produced by trypanosoma cruzi |
| topic | Exosomes Trypanosoma cruzi Microvesicles cell invasion Cell evasion |
| url | http://journal.frontiersin.org/Journal/10.3389/fcimb.2016.00161/full |
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