Fine particulate matter exposure and renal function: A population-based study among pregnant women in China
Background: Fine particulate matter (PM2.5) is the most serious environmental threat worldwide. The nephrotoxicity of PM2.5 has been demonstrated in older adults, but no study has addressed the impacts of PM2.5 exposure on renal function in pregnant women, who are recognized to be vulnerable and sus...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-08-01
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| Series: | Environment International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412020317608 |
| _version_ | 1819078247393001472 |
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| author | Yan Zhao Jing Cai Xinlei Zhu Aaron van Donkelaar Randall V. Martin Jing Hua Haidong Kan |
| author_facet | Yan Zhao Jing Cai Xinlei Zhu Aaron van Donkelaar Randall V. Martin Jing Hua Haidong Kan |
| author_sort | Yan Zhao |
| collection | DOAJ |
| description | Background: Fine particulate matter (PM2.5) is the most serious environmental threat worldwide. The nephrotoxicity of PM2.5 has been demonstrated in older adults, but no study has addressed the impacts of PM2.5 exposure on renal function in pregnant women, who are recognized to be vulnerable and susceptible to PM2.5 exposure. Objective: To evaluate whether exposures to PM2.5 total mass and its chemical constituents were associated with reduced renal function among pregnant women in China. Methods: We measured serum concentrations of urea nitrogen (UN), uric acid (UA) and creatinine for 10,052 pregnant women in Shanghai, China. Exposures to PM2.5 total mass and its 5 key chemical constituents during the whole pregnancy and each trimester of pregnancy was represented by satellite-based models. Results: Exposures to PM2.5 total mass and its chemical constituents of organic matter (OM), black carbon (BC), nitrate (NO3−) and ammonium (NH4+) were positively associated with serum levels of UN and UA, and negatively associated with estimated glomerular filtration rate (eGFR). An interquartile rang (IQR) increase in PM2.5 total mass, OM, BC, NO3– and NH4+ exposure in third trimester was associated with 1.33 (β = -1.33, 95% CI, −1.79, −0.87), 1.67 (β = -1.67, 95% CI, −2.26, −1.07), 1.29 (β = -1.29, 95% CI,-1.89, −0.70), 1.16 (β = -1.16, 95% CI,-1.66, −0.65) and 0.76 (β = -0.76, 95% CI, −1.08, −0.44) mL/min/1.73 m2 decrease in eGFR, respectively. Conclusion: We concluded that exposures to PM2.5 during pregnancy were associated with decreased renal function among pregnant women. |
| first_indexed | 2024-12-21T19:10:04Z |
| format | Article |
| id | doaj.art-3907c248c70a430bb9578d831414d60f |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-12-21T19:10:04Z |
| publishDate | 2020-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-3907c248c70a430bb9578d831414d60f2022-12-21T18:53:14ZengElsevierEnvironment International0160-41202020-08-01141105805Fine particulate matter exposure and renal function: A population-based study among pregnant women in ChinaYan Zhao0Jing Cai1Xinlei Zhu2Aaron van Donkelaar3Randall V. Martin4Jing Hua5Haidong Kan6Department of Women & Children's Health Care, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, ChinaSchool of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Laboratory of Health Technology Assessment, Fudan University, Shanghai, ChinaSchool of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Laboratory of Health Technology Assessment, Fudan University, Shanghai, ChinaDepartment of Physics and Atmospheric Science, Dalhousie University, Halifax, N.S. Canada; Department of Energy, Environmental & Chemical Engineering, Washington University in St. Louis, St. Louis, MO, United StatesDepartment of Physics and Atmospheric Science, Dalhousie University, Halifax, N.S. Canada; Department of Energy, Environmental & Chemical Engineering, Washington University in St. Louis, St. Louis, MO, United StatesDepartment of Women & Children's Health Care, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China; Corresponding authors at: School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Laboratory of Health Technology Assessment, Fudan University, No. 130 Dong-An Road, Shanghai 200032, China (H. Kan). Department of Women & Children's Health Care, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, No. 2699 Gaoke Road, Shanghai, 200042, China (J. Hua).School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Laboratory of Health Technology Assessment, Fudan University, Shanghai, China; Corresponding authors at: School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Laboratory of Health Technology Assessment, Fudan University, No. 130 Dong-An Road, Shanghai 200032, China (H. Kan). Department of Women & Children's Health Care, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, No. 2699 Gaoke Road, Shanghai, 200042, China (J. Hua).Background: Fine particulate matter (PM2.5) is the most serious environmental threat worldwide. The nephrotoxicity of PM2.5 has been demonstrated in older adults, but no study has addressed the impacts of PM2.5 exposure on renal function in pregnant women, who are recognized to be vulnerable and susceptible to PM2.5 exposure. Objective: To evaluate whether exposures to PM2.5 total mass and its chemical constituents were associated with reduced renal function among pregnant women in China. Methods: We measured serum concentrations of urea nitrogen (UN), uric acid (UA) and creatinine for 10,052 pregnant women in Shanghai, China. Exposures to PM2.5 total mass and its 5 key chemical constituents during the whole pregnancy and each trimester of pregnancy was represented by satellite-based models. Results: Exposures to PM2.5 total mass and its chemical constituents of organic matter (OM), black carbon (BC), nitrate (NO3−) and ammonium (NH4+) were positively associated with serum levels of UN and UA, and negatively associated with estimated glomerular filtration rate (eGFR). An interquartile rang (IQR) increase in PM2.5 total mass, OM, BC, NO3– and NH4+ exposure in third trimester was associated with 1.33 (β = -1.33, 95% CI, −1.79, −0.87), 1.67 (β = -1.67, 95% CI, −2.26, −1.07), 1.29 (β = -1.29, 95% CI,-1.89, −0.70), 1.16 (β = -1.16, 95% CI,-1.66, −0.65) and 0.76 (β = -0.76, 95% CI, −1.08, −0.44) mL/min/1.73 m2 decrease in eGFR, respectively. Conclusion: We concluded that exposures to PM2.5 during pregnancy were associated with decreased renal function among pregnant women.http://www.sciencedirect.com/science/article/pii/S0160412020317608Ambient air pollutionPM2.5Chemical constituentsRenal functionPregnant woman |
| spellingShingle | Yan Zhao Jing Cai Xinlei Zhu Aaron van Donkelaar Randall V. Martin Jing Hua Haidong Kan Fine particulate matter exposure and renal function: A population-based study among pregnant women in China Environment International Ambient air pollution PM2.5 Chemical constituents Renal function Pregnant woman |
| title | Fine particulate matter exposure and renal function: A population-based study among pregnant women in China |
| title_full | Fine particulate matter exposure and renal function: A population-based study among pregnant women in China |
| title_fullStr | Fine particulate matter exposure and renal function: A population-based study among pregnant women in China |
| title_full_unstemmed | Fine particulate matter exposure and renal function: A population-based study among pregnant women in China |
| title_short | Fine particulate matter exposure and renal function: A population-based study among pregnant women in China |
| title_sort | fine particulate matter exposure and renal function a population based study among pregnant women in china |
| topic | Ambient air pollution PM2.5 Chemical constituents Renal function Pregnant woman |
| url | http://www.sciencedirect.com/science/article/pii/S0160412020317608 |
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