A critical analysis of computational protein design with sparse residue interaction graphs.

A critical analysis of computational protein design with sparse residue interaction graphs.

Protein design algorithms enumerate a combinatorial number of candidate structures to compute the Global Minimum Energy Conformation (GMEC). To efficiently find the GMEC, protein design algorithms must methodically reduce the conformational search space. By applying distance and energy cutoffs, the...

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Bibliographic Details
Main Authors: Swati Jain, Jonathan D Jou, Ivelin S Georgiev, Bruce R Donald
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-03-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC5391103?pdf=render

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