Clinical and genetic aspects of testicular germ cell tumours
<p>Abstract</p> <p>In this paper we review clinical and genetic aspects of testicular germ cell tumours (TGCTs). TGCT is the most common type of malignant disorder in men aged 15-40 years. Its incidence has increased sharply in recent years. Fortunately, survival of patients with T...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2008-02-01
|
| Series: | Hereditary Cancer in Clinical Practice |
| Subjects: | |
| Online Access: | http://www.hccpjournal.com/content/6/1/3 |
| _version_ | 1811319883161403392 |
|---|---|
| author | Holzik Martijn Sijmons Rolf H Hoekstra-Weebers Josette EHM Sleijfer Dirk T Hoekstra Harald J |
| author_facet | Holzik Martijn Sijmons Rolf H Hoekstra-Weebers Josette EHM Sleijfer Dirk T Hoekstra Harald J |
| author_sort | Holzik Martijn |
| collection | DOAJ |
| description | <p>Abstract</p> <p>In this paper we review clinical and genetic aspects of testicular germ cell tumours (TGCTs). TGCT is the most common type of malignant disorder in men aged 15-40 years. Its incidence has increased sharply in recent years. Fortunately, survival of patients with TGCT has improved enormously, which can chiefly be attributed to the cisplatin-based polychemotherapy that was introduced in the nineteen eighties to treat patients with metastasized TGCT. In addition, new strategies have been developed in the surgical approach to metastasized/non-metastasized TGCT and alterations have been made to the radiotherapy technique and radiation dose for seminoma. Family history of TGCT is among the strongest risk factors for this tumour type. Although this fact and others suggest the existence of genetic predisposition to develop TGCT, no germline mutations conferring high risk of developing TGCT have been identified so far. A small deletion, referred to as gr/gr, identified on the Y chromosome is probably associated with only a modest increase in TGCT risk, and linkage of familial TGCT to the Xq27 region has not been confirmed yet. Whether highly penetrant TGCT-predisposing mutations truly exist or familial clustering of TGCT can be explained by combinations of weak predispositions, shared in utero or postnatal risks factors and coincidental somatic mutations is an intriguing puzzle, still waiting to be solved.</p> |
| first_indexed | 2024-04-13T12:51:02Z |
| format | Article |
| id | doaj.art-3909e01880534bd89b614f894f0760a5 |
| institution | Directory Open Access Journal |
| issn | 1897-4287 |
| language | English |
| last_indexed | 2024-04-13T12:51:02Z |
| publishDate | 2008-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Hereditary Cancer in Clinical Practice |
| spelling | doaj.art-3909e01880534bd89b614f894f0760a52022-12-22T02:46:13ZengBMCHereditary Cancer in Clinical Practice1897-42872008-02-016131410.1186/1897-4287-6-1-3Clinical and genetic aspects of testicular germ cell tumoursHolzik MartijnSijmons Rolf HHoekstra-Weebers Josette EHMSleijfer Dirk THoekstra Harald J<p>Abstract</p> <p>In this paper we review clinical and genetic aspects of testicular germ cell tumours (TGCTs). TGCT is the most common type of malignant disorder in men aged 15-40 years. Its incidence has increased sharply in recent years. Fortunately, survival of patients with TGCT has improved enormously, which can chiefly be attributed to the cisplatin-based polychemotherapy that was introduced in the nineteen eighties to treat patients with metastasized TGCT. In addition, new strategies have been developed in the surgical approach to metastasized/non-metastasized TGCT and alterations have been made to the radiotherapy technique and radiation dose for seminoma. Family history of TGCT is among the strongest risk factors for this tumour type. Although this fact and others suggest the existence of genetic predisposition to develop TGCT, no germline mutations conferring high risk of developing TGCT have been identified so far. A small deletion, referred to as gr/gr, identified on the Y chromosome is probably associated with only a modest increase in TGCT risk, and linkage of familial TGCT to the Xq27 region has not been confirmed yet. Whether highly penetrant TGCT-predisposing mutations truly exist or familial clustering of TGCT can be explained by combinations of weak predispositions, shared in utero or postnatal risks factors and coincidental somatic mutations is an intriguing puzzle, still waiting to be solved.</p>http://www.hccpjournal.com/content/6/1/3testicular germ cell tumourgeneticsfamilialtherapyreview |
| spellingShingle | Holzik Martijn Sijmons Rolf H Hoekstra-Weebers Josette EHM Sleijfer Dirk T Hoekstra Harald J Clinical and genetic aspects of testicular germ cell tumours Hereditary Cancer in Clinical Practice testicular germ cell tumour genetics familial therapy review |
| title | Clinical and genetic aspects of testicular germ cell tumours |
| title_full | Clinical and genetic aspects of testicular germ cell tumours |
| title_fullStr | Clinical and genetic aspects of testicular germ cell tumours |
| title_full_unstemmed | Clinical and genetic aspects of testicular germ cell tumours |
| title_short | Clinical and genetic aspects of testicular germ cell tumours |
| title_sort | clinical and genetic aspects of testicular germ cell tumours |
| topic | testicular germ cell tumour genetics familial therapy review |
| url | http://www.hccpjournal.com/content/6/1/3 |
| work_keys_str_mv | AT holzikmartijn clinicalandgeneticaspectsoftesticulargermcelltumours AT sijmonsrolfh clinicalandgeneticaspectsoftesticulargermcelltumours AT hoekstraweebersjosetteehm clinicalandgeneticaspectsoftesticulargermcelltumours AT sleijferdirkt clinicalandgeneticaspectsoftesticulargermcelltumours AT hoekstraharaldj clinicalandgeneticaspectsoftesticulargermcelltumours |