The role of macrophage polarization and cellular crosstalk in the pulmonary fibrotic microenvironment: a review
Abstract Pulmonary fibrosis (PF) is a progressive interstitial inflammatory disease with a high mortality rate. Patients with PF commonly experience a chronic dry cough and progressive dyspnoea for years without effective mitigation. The pathogenesis of PF is believed to be associated with dysfuncti...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | Cell Communication and Signaling |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12964-024-01557-2 |
| _version_ | 1797266689900937216 |
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| author | Bo-wen Zhou Hua-man Liu Fei Xu Xin-hua Jia |
| author_facet | Bo-wen Zhou Hua-man Liu Fei Xu Xin-hua Jia |
| author_sort | Bo-wen Zhou |
| collection | DOAJ |
| description | Abstract Pulmonary fibrosis (PF) is a progressive interstitial inflammatory disease with a high mortality rate. Patients with PF commonly experience a chronic dry cough and progressive dyspnoea for years without effective mitigation. The pathogenesis of PF is believed to be associated with dysfunctional macrophage polarization, fibroblast proliferation, and the loss of epithelial cells. Thus, it is of great importance and necessity to explore the interactions among macrophages, fibroblasts, and alveolar epithelial cells in lung fibrosis, as well as in the pro-fibrotic microenvironment. In this review, we discuss the latest studies that have investigated macrophage polarization and activation of non-immune cells in the context of PF pathogenesis and progression. Next, we discuss how profibrotic cellular crosstalk is promoted in the PF microenvironment by multiple cytokines, chemokines, and signalling pathways. And finally, we discuss the potential mechanisms of fibrogenesis development and efficient therapeutic strategies for the disease. Herein, we provide a comprehensive summary of the vital role of macrophage polarization in PF and its profibrotic crosstalk with fibroblasts and alveolar epithelial cells and suggest potential treatment strategies to target their cellular communication in the microenvironment. |
| first_indexed | 2024-04-25T01:04:41Z |
| format | Article |
| id | doaj.art-390a1b4344cc45fe9692c56ffd6d346b |
| institution | Directory Open Access Journal |
| issn | 1478-811X |
| language | English |
| last_indexed | 2024-04-25T01:04:41Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj.art-390a1b4344cc45fe9692c56ffd6d346b2024-03-10T12:18:19ZengBMCCell Communication and Signaling1478-811X2024-03-0122111610.1186/s12964-024-01557-2The role of macrophage polarization and cellular crosstalk in the pulmonary fibrotic microenvironment: a reviewBo-wen Zhou0Hua-man Liu1Fei Xu2Xin-hua Jia3The First School of Clinical Medicine, Shandong University of Traditional Chinese MedicineDepartment of General Medicine, Affiliated Hospital of Shandong University of Traditional Chinese MedicineDepartment of Pneumology and Critical Care Medicine, Affiliated Hospital of Shandong University of Traditional Chinese MedicineDepartment of Pneumology and Critical Care Medicine, Affiliated Hospital of Shandong University of Traditional Chinese MedicineAbstract Pulmonary fibrosis (PF) is a progressive interstitial inflammatory disease with a high mortality rate. Patients with PF commonly experience a chronic dry cough and progressive dyspnoea for years without effective mitigation. The pathogenesis of PF is believed to be associated with dysfunctional macrophage polarization, fibroblast proliferation, and the loss of epithelial cells. Thus, it is of great importance and necessity to explore the interactions among macrophages, fibroblasts, and alveolar epithelial cells in lung fibrosis, as well as in the pro-fibrotic microenvironment. In this review, we discuss the latest studies that have investigated macrophage polarization and activation of non-immune cells in the context of PF pathogenesis and progression. Next, we discuss how profibrotic cellular crosstalk is promoted in the PF microenvironment by multiple cytokines, chemokines, and signalling pathways. And finally, we discuss the potential mechanisms of fibrogenesis development and efficient therapeutic strategies for the disease. Herein, we provide a comprehensive summary of the vital role of macrophage polarization in PF and its profibrotic crosstalk with fibroblasts and alveolar epithelial cells and suggest potential treatment strategies to target their cellular communication in the microenvironment.https://doi.org/10.1186/s12964-024-01557-2PFMacrophage polarizationFibroblastAlveolar epithelial cellCrosstalk |
| spellingShingle | Bo-wen Zhou Hua-man Liu Fei Xu Xin-hua Jia The role of macrophage polarization and cellular crosstalk in the pulmonary fibrotic microenvironment: a review Cell Communication and Signaling PF Macrophage polarization Fibroblast Alveolar epithelial cell Crosstalk |
| title | The role of macrophage polarization and cellular crosstalk in the pulmonary fibrotic microenvironment: a review |
| title_full | The role of macrophage polarization and cellular crosstalk in the pulmonary fibrotic microenvironment: a review |
| title_fullStr | The role of macrophage polarization and cellular crosstalk in the pulmonary fibrotic microenvironment: a review |
| title_full_unstemmed | The role of macrophage polarization and cellular crosstalk in the pulmonary fibrotic microenvironment: a review |
| title_short | The role of macrophage polarization and cellular crosstalk in the pulmonary fibrotic microenvironment: a review |
| title_sort | role of macrophage polarization and cellular crosstalk in the pulmonary fibrotic microenvironment a review |
| topic | PF Macrophage polarization Fibroblast Alveolar epithelial cell Crosstalk |
| url | https://doi.org/10.1186/s12964-024-01557-2 |
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