Synthesis and Anticancer Evaluation of New Indole-Based Tyrphostin Derivatives and Their (<i>p</i>-Cymene)dichloridoruthenium(II) Complexes

Synthesis and Anticancer Evaluation of New Indole-Based Tyrphostin Derivatives and Their (<i>p</i>-Cymene)dichloridoruthenium(II) Complexes

New <i>N</i>-alkylindole-substituted 2-(pyrid-3-yl)-acrylonitriles with putative kinase inhibitory activity and their (<i>p</i>-cymene)Ru(II) piano-stool complexes were prepared and tested for their antiproliferative efficacy in various cancer models. Some of the indole-based...

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Bibliographic Details
Main Authors: Natalie Oberhuber, Hindole Ghosh, Bianca Nitzsche, Prasad Dandawate, Michael Höpfner, Rainer Schobert, Bernhard Biersack
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:International Journal of Molecular Sciences
Subjects:
anticancer agents
kinase inhibitors
tyrphostin
indoles
VEGFR inhibition
molecular docking
Online Access:https://www.mdpi.com/1422-0067/24/1/854

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