A Potential Role for the Inhibition of PI3K Signaling in Glioblastoma Therapy.

A Potential Role for the Inhibition of PI3K Signaling in Glioblastoma Therapy.

Glioblastoma multiforme (GBM) is the most common primary brain tumor and among the most difficult to treat malignancies per se. In almost 90% of all GBM alterations in the PI3K/Akt/mTOR have been found, making this survival cascade a promising therapeutic target, particular for combination therapy t...

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Main Authors: Stephanie Ströbele, Matthias Schneider, Lukas Schneele, Markus D Siegelin, Lisa Nonnenmacher, Shaoxia Zhou, Georg Karpel-Massler, Mike-Andrew Westhoff, Marc-Eric Halatsch, Klaus-Michael Debatin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4488267?pdf=render

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