Spontaneous Hair Cell Regeneration Is Prevented by Increased Notch Signaling in Supporting Cells

Spontaneous Hair Cell Regeneration Is Prevented by Increased Notch Signaling in Supporting Cells

During embryonic development, differentiation of cochlear progenitor cells into hair cells (HCs) or supporting cells (SCs) is partially controlled through Notch signaling. Many studies have shown that inhibition of Notch signaling allows SCs to convert into HCs in both normal and drug damaged neonat...

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Bibliographic Details
Main Authors: Melissa M. McGovern, Luyi Zhou, Michelle R. Randle, Brandon C. Cox
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
hair cell regeneration
cochlea
Notch
CreER
Tet-On
NICD
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2018.00120/full

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