Atherogenic index of plasma is related to coronary atherosclerotic disease in elderly individuals: a cross-sectional study
Abstract Background Dyslipidaemia plays an important role in coronary atherosclerotic disease (CAD). The relationship between the atherogenic index of plasma (AIP) and CAD in elderly individuals was explored in this study. Methods Elderly individuals (age ≥ 65 years) who underwent coronary angiograp...
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| Format: | Article |
| Language: | English |
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BMC
2021-07-01
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| Series: | Lipids in Health and Disease |
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| Online Access: | https://doi.org/10.1186/s12944-021-01496-8 |
| _version_ | 1818652075734597632 |
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| author | Haomin Huang Xiaolong Yu Lamei Li Ganwei Shi Feng Li Jianqiang Xiao Zhihua Yun Gaojun Cai |
| author_facet | Haomin Huang Xiaolong Yu Lamei Li Ganwei Shi Feng Li Jianqiang Xiao Zhihua Yun Gaojun Cai |
| author_sort | Haomin Huang |
| collection | DOAJ |
| description | Abstract Background Dyslipidaemia plays an important role in coronary atherosclerotic disease (CAD). The relationship between the atherogenic index of plasma (AIP) and CAD in elderly individuals was explored in this study. Methods Elderly individuals (age ≥ 65 years) who underwent coronary angiography from January 2016 to October 2020 were consecutively enrolled in the study. Results A total of 1313 individuals, including 354 controls (non-CAD) and 959 CAD patients, were enrolled. In univariate analysis of all populations, the adjusted AIP (aAIP) in the CAD group was 1.13 (0.96, 1.3), which was significantly higher than that in the controls [1.07 (0.89, 1.26)]. However, in subgroup analyses, this phenomenon was only present in males. In addition, further study showed that aAIP was positively related to CAD severity. In binary logistic regression analyses, after adjusting for sex, age, smoking status, primary hypertension (PH), type 2 diabetes mellitus (T2DM), heart rate (HR), white blood cell (WBC) and platelet (PLT), AIP remained independently related to CAD in elderly individuals and was superior to traditional and other nontraditional lipid indices. Subgroup analyses showed that AIP independently influenced CAD risk in males. Ultimately, sensitivity analyses were performed excluding all coronary emergencies, and the final results were similar. Conclusions AIP was positively related to the risk and severity of CAD in elderly individuals and was superior to traditional and other nontraditional lipid profiles. However, this association only exists in elderly males. |
| first_indexed | 2024-12-17T02:16:15Z |
| format | Article |
| id | doaj.art-3910383fa86b47168e6f5c1b749b9b77 |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-12-17T02:16:15Z |
| publishDate | 2021-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-3910383fa86b47168e6f5c1b749b9b772022-12-21T22:07:23ZengBMCLipids in Health and Disease1476-511X2021-07-012011910.1186/s12944-021-01496-8Atherogenic index of plasma is related to coronary atherosclerotic disease in elderly individuals: a cross-sectional studyHaomin Huang0Xiaolong Yu1Lamei Li2Ganwei Shi3Feng Li4Jianqiang Xiao5Zhihua Yun6Gaojun Cai7Department of Cardiology, Wujin Hospital Affiliated with Jiangsu University, The Wujin Clinical College of Xuzhou Medical UniversityDepartment of Ultrasound, Wujin Hospital Affiliated with Jiangsu University, The Wujin Clinical College of Xuzhou Medical UniversityDepartment of Cardiology, Wujin Hospital Affiliated with Jiangsu University, The Wujin Clinical College of Xuzhou Medical UniversityDepartment of Cardiology, Wujin Hospital Affiliated with Jiangsu University, The Wujin Clinical College of Xuzhou Medical UniversityDepartment of Cardiology, Wujin Hospital Affiliated with Jiangsu University, The Wujin Clinical College of Xuzhou Medical UniversityDepartment of Cardiology, Wujin Hospital Affiliated with Jiangsu University, The Wujin Clinical College of Xuzhou Medical UniversityDepartment of Clinical Laboratory, Wujin Hospital Affiliated with Jiangsu University, The Wujin Clinical College of Xuzhou Medical UniversityDepartment of Cardiology, Wujin Hospital Affiliated with Jiangsu University, The Wujin Clinical College of Xuzhou Medical UniversityAbstract Background Dyslipidaemia plays an important role in coronary atherosclerotic disease (CAD). The relationship between the atherogenic index of plasma (AIP) and CAD in elderly individuals was explored in this study. Methods Elderly individuals (age ≥ 65 years) who underwent coronary angiography from January 2016 to October 2020 were consecutively enrolled in the study. Results A total of 1313 individuals, including 354 controls (non-CAD) and 959 CAD patients, were enrolled. In univariate analysis of all populations, the adjusted AIP (aAIP) in the CAD group was 1.13 (0.96, 1.3), which was significantly higher than that in the controls [1.07 (0.89, 1.26)]. However, in subgroup analyses, this phenomenon was only present in males. In addition, further study showed that aAIP was positively related to CAD severity. In binary logistic regression analyses, after adjusting for sex, age, smoking status, primary hypertension (PH), type 2 diabetes mellitus (T2DM), heart rate (HR), white blood cell (WBC) and platelet (PLT), AIP remained independently related to CAD in elderly individuals and was superior to traditional and other nontraditional lipid indices. Subgroup analyses showed that AIP independently influenced CAD risk in males. Ultimately, sensitivity analyses were performed excluding all coronary emergencies, and the final results were similar. Conclusions AIP was positively related to the risk and severity of CAD in elderly individuals and was superior to traditional and other nontraditional lipid profiles. However, this association only exists in elderly males.https://doi.org/10.1186/s12944-021-01496-8Atherogenic index of plasmaCoronary atherosclerotic diseaseElderlyLipid metabolismAtherosclerosisCross-sectional study |
| spellingShingle | Haomin Huang Xiaolong Yu Lamei Li Ganwei Shi Feng Li Jianqiang Xiao Zhihua Yun Gaojun Cai Atherogenic index of plasma is related to coronary atherosclerotic disease in elderly individuals: a cross-sectional study Lipids in Health and Disease Atherogenic index of plasma Coronary atherosclerotic disease Elderly Lipid metabolism Atherosclerosis Cross-sectional study |
| title | Atherogenic index of plasma is related to coronary atherosclerotic disease in elderly individuals: a cross-sectional study |
| title_full | Atherogenic index of plasma is related to coronary atherosclerotic disease in elderly individuals: a cross-sectional study |
| title_fullStr | Atherogenic index of plasma is related to coronary atherosclerotic disease in elderly individuals: a cross-sectional study |
| title_full_unstemmed | Atherogenic index of plasma is related to coronary atherosclerotic disease in elderly individuals: a cross-sectional study |
| title_short | Atherogenic index of plasma is related to coronary atherosclerotic disease in elderly individuals: a cross-sectional study |
| title_sort | atherogenic index of plasma is related to coronary atherosclerotic disease in elderly individuals a cross sectional study |
| topic | Atherogenic index of plasma Coronary atherosclerotic disease Elderly Lipid metabolism Atherosclerosis Cross-sectional study |
| url | https://doi.org/10.1186/s12944-021-01496-8 |
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