Lifestyle changes and risk of tuberculosis in patients with type 2 diabetes mellitus: A nationwide cohort study
We investigated the impacts of lifestyle changes, namely, smoking, alcohol intake, and exercise, on the development of tuberculosis (TB) in patients with type 2 diabetes mellitus (T2DM). A retrospective population-based cohort study used data from the Korean National Health Insurance system database...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.1009493/full |
| _version_ | 1828142946106474496 |
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| author | Jiho Park Ji Hyun Yoon Hyun Kyun Ki Kyungdo Han Hyungjin Kim |
| author_facet | Jiho Park Ji Hyun Yoon Hyun Kyun Ki Kyungdo Han Hyungjin Kim |
| author_sort | Jiho Park |
| collection | DOAJ |
| description | We investigated the impacts of lifestyle changes, namely, smoking, alcohol intake, and exercise, on the development of tuberculosis (TB) in patients with type 2 diabetes mellitus (T2DM). A retrospective population-based cohort study used data from the Korean National Health Insurance system database. We examined subjects diagnosed with T2DM and without previous history of TB between 2009 and 2012 who underwent two serial health examinations. The study participants were classified into each of the four groups based on changes in the patterns of smoking, alcohol intake, and exercise at the time of the second examination. The outcome of the study was newly diagnosed TB in patients with T2DM. Among 1,659,804 included subjects, TB was newly diagnosed with 10,288 subjects. Both consistent smokers (HR 1.406; 95% CI 1.333–1.483) and new smokers (HR 1.185; 95% CI 1.063–1.320) had a higher TB risk than smoking quitters (HR 1.107; 95% CI 1.009–1.216) and never smokers. Both consistent heavy drinkers (HR 1.281; 95% CI 1.172–1.399) and heavy drinking quitters (HR 1.247; 95% CI 1.147–1.356) had a higher TB risk than new heavy drinkers and never drinkers. With respect to exercise, persistent non-exercisers (HR 1.309; 95% CI 1.72–1.399) and exercise quitters (HR 1.164; 95% CI 1.066–1.271) had a higher TB risk than new exercisers. In the subgroup analysis, a significant interaction was observed between lifestyle changes and age. We found that lifestyle changes were associated with development of TB in patients with T2DM. These results suggest that lifestyle management could be a valuable strategy for control of TB in Korea. |
| first_indexed | 2024-04-11T19:50:06Z |
| format | Article |
| id | doaj.art-3910959c5f644b82a6d9fb85cc32f04d |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-11T19:50:06Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-3910959c5f644b82a6d9fb85cc32f04d2022-12-22T04:06:20ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-10-011310.3389/fendo.2022.10094931009493Lifestyle changes and risk of tuberculosis in patients with type 2 diabetes mellitus: A nationwide cohort studyJiho Park0Ji Hyun Yoon1Hyun Kyun Ki2Kyungdo Han3Hyungjin Kim4Department of Medicine, Konkuk University of Medical Center, School of Medicine, Konkuk University, Seoul, South KoreaDepartment of Medicine, Konkuk University of Medical Center, School of Medicine, Konkuk University, Seoul, South KoreaDepartment of Medicine, Konkuk University of Medical Center, School of Medicine, Konkuk University, Seoul, South KoreaDepartment of Statistics and Actuarial Science, Soongsil University, Seoul, South KoreaDepartment of Medical Humanities, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, South KoreaWe investigated the impacts of lifestyle changes, namely, smoking, alcohol intake, and exercise, on the development of tuberculosis (TB) in patients with type 2 diabetes mellitus (T2DM). A retrospective population-based cohort study used data from the Korean National Health Insurance system database. We examined subjects diagnosed with T2DM and without previous history of TB between 2009 and 2012 who underwent two serial health examinations. The study participants were classified into each of the four groups based on changes in the patterns of smoking, alcohol intake, and exercise at the time of the second examination. The outcome of the study was newly diagnosed TB in patients with T2DM. Among 1,659,804 included subjects, TB was newly diagnosed with 10,288 subjects. Both consistent smokers (HR 1.406; 95% CI 1.333–1.483) and new smokers (HR 1.185; 95% CI 1.063–1.320) had a higher TB risk than smoking quitters (HR 1.107; 95% CI 1.009–1.216) and never smokers. Both consistent heavy drinkers (HR 1.281; 95% CI 1.172–1.399) and heavy drinking quitters (HR 1.247; 95% CI 1.147–1.356) had a higher TB risk than new heavy drinkers and never drinkers. With respect to exercise, persistent non-exercisers (HR 1.309; 95% CI 1.72–1.399) and exercise quitters (HR 1.164; 95% CI 1.066–1.271) had a higher TB risk than new exercisers. In the subgroup analysis, a significant interaction was observed between lifestyle changes and age. We found that lifestyle changes were associated with development of TB in patients with T2DM. These results suggest that lifestyle management could be a valuable strategy for control of TB in Korea.https://www.frontiersin.org/articles/10.3389/fendo.2022.1009493/fulldiabetes mellitussmokingalcohol intakeexercisetuberculosis |
| spellingShingle | Jiho Park Ji Hyun Yoon Hyun Kyun Ki Kyungdo Han Hyungjin Kim Lifestyle changes and risk of tuberculosis in patients with type 2 diabetes mellitus: A nationwide cohort study Frontiers in Endocrinology diabetes mellitus smoking alcohol intake exercise tuberculosis |
| title | Lifestyle changes and risk of tuberculosis in patients with type 2 diabetes mellitus: A nationwide cohort study |
| title_full | Lifestyle changes and risk of tuberculosis in patients with type 2 diabetes mellitus: A nationwide cohort study |
| title_fullStr | Lifestyle changes and risk of tuberculosis in patients with type 2 diabetes mellitus: A nationwide cohort study |
| title_full_unstemmed | Lifestyle changes and risk of tuberculosis in patients with type 2 diabetes mellitus: A nationwide cohort study |
| title_short | Lifestyle changes and risk of tuberculosis in patients with type 2 diabetes mellitus: A nationwide cohort study |
| title_sort | lifestyle changes and risk of tuberculosis in patients with type 2 diabetes mellitus a nationwide cohort study |
| topic | diabetes mellitus smoking alcohol intake exercise tuberculosis |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.1009493/full |
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