Orchestrating Cellular Balance: ncRNAs and RNA Interactions at the Dominant of Autophagy Regulation in Cancer
Autophagy, a complex and highly regulated cellular process, is critical for the maintenance of cellular homeostasis by lysosomal degradation of cellular debris, intracellular pathogens, and dysfunctional organelles. It has become an interesting and attractive topic in cancer because of its dual role...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-01-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/25/3/1561 |
| _version_ | 1797318649815498752 |
|---|---|
| author | Xueni Yang Shizheng Xiong Xinmiao Zhao Jiaming Jin Xinbing Yang Yajing Du Linjie Zhao Zhiheng He Chengjun Gong Li Guo Tingming Liang |
| author_facet | Xueni Yang Shizheng Xiong Xinmiao Zhao Jiaming Jin Xinbing Yang Yajing Du Linjie Zhao Zhiheng He Chengjun Gong Li Guo Tingming Liang |
| author_sort | Xueni Yang |
| collection | DOAJ |
| description | Autophagy, a complex and highly regulated cellular process, is critical for the maintenance of cellular homeostasis by lysosomal degradation of cellular debris, intracellular pathogens, and dysfunctional organelles. It has become an interesting and attractive topic in cancer because of its dual role as a tumor suppressor and cell survival mechanism. As a highly conserved pathway, autophagy is strictly regulated by diverse non-coding RNAs (ncRNAs), ranging from short and flexible miRNAs to lncRNAs and even circRNAs, which largely contribute to autophagy regulatory networks via complex RNA interactions. The potential roles of RNA interactions during autophagy, especially in cancer procession and further anticancer treatment, will aid our understanding of related RNAs in autophagy in tumorigenesis and cancer treatment. Herein, we mainly summarized autophagy-related mRNAs and ncRNAs, also providing RNA–RNA interactions and their potential roles in cancer prognosis, which may deepen our understanding of the relationships between various RNAs during autophagy and provide new insights into autophagy-related therapeutic strategies in personalized medicine. |
| first_indexed | 2024-03-08T03:55:25Z |
| format | Article |
| id | doaj.art-39114d744e4b40f3aba14cb00e2ca02c |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-08T03:55:25Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-39114d744e4b40f3aba14cb00e2ca02c2024-02-09T15:13:43ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-01-01253156110.3390/ijms25031561Orchestrating Cellular Balance: ncRNAs and RNA Interactions at the Dominant of Autophagy Regulation in CancerXueni Yang0Shizheng Xiong1Xinmiao Zhao2Jiaming Jin3Xinbing Yang4Yajing Du5Linjie Zhao6Zhiheng He7Chengjun Gong8Li Guo9Tingming Liang10State Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, Nanjing 210023, ChinaState Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, Nanjing 210023, ChinaState Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, Nanjing 210023, ChinaState Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, Nanjing 210023, ChinaJiangsu Key Laboratory for Molecular and Medical Biotechnology, School of Life Science, Nanjing Normal University, Nanjing 210023, ChinaJiangsu Key Laboratory for Molecular and Medical Biotechnology, School of Life Science, Nanjing Normal University, Nanjing 210023, ChinaState Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, Nanjing 210023, ChinaState Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, Nanjing 210023, ChinaState Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, Nanjing 210023, ChinaState Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, Nanjing 210023, ChinaJiangsu Key Laboratory for Molecular and Medical Biotechnology, School of Life Science, Nanjing Normal University, Nanjing 210023, ChinaAutophagy, a complex and highly regulated cellular process, is critical for the maintenance of cellular homeostasis by lysosomal degradation of cellular debris, intracellular pathogens, and dysfunctional organelles. It has become an interesting and attractive topic in cancer because of its dual role as a tumor suppressor and cell survival mechanism. As a highly conserved pathway, autophagy is strictly regulated by diverse non-coding RNAs (ncRNAs), ranging from short and flexible miRNAs to lncRNAs and even circRNAs, which largely contribute to autophagy regulatory networks via complex RNA interactions. The potential roles of RNA interactions during autophagy, especially in cancer procession and further anticancer treatment, will aid our understanding of related RNAs in autophagy in tumorigenesis and cancer treatment. Herein, we mainly summarized autophagy-related mRNAs and ncRNAs, also providing RNA–RNA interactions and their potential roles in cancer prognosis, which may deepen our understanding of the relationships between various RNAs during autophagy and provide new insights into autophagy-related therapeutic strategies in personalized medicine.https://www.mdpi.com/1422-0067/25/3/1561autophagymiRNAlncRNAcircRNAinteractioncancer |
| spellingShingle | Xueni Yang Shizheng Xiong Xinmiao Zhao Jiaming Jin Xinbing Yang Yajing Du Linjie Zhao Zhiheng He Chengjun Gong Li Guo Tingming Liang Orchestrating Cellular Balance: ncRNAs and RNA Interactions at the Dominant of Autophagy Regulation in Cancer International Journal of Molecular Sciences autophagy miRNA lncRNA circRNA interaction cancer |
| title | Orchestrating Cellular Balance: ncRNAs and RNA Interactions at the Dominant of Autophagy Regulation in Cancer |
| title_full | Orchestrating Cellular Balance: ncRNAs and RNA Interactions at the Dominant of Autophagy Regulation in Cancer |
| title_fullStr | Orchestrating Cellular Balance: ncRNAs and RNA Interactions at the Dominant of Autophagy Regulation in Cancer |
| title_full_unstemmed | Orchestrating Cellular Balance: ncRNAs and RNA Interactions at the Dominant of Autophagy Regulation in Cancer |
| title_short | Orchestrating Cellular Balance: ncRNAs and RNA Interactions at the Dominant of Autophagy Regulation in Cancer |
| title_sort | orchestrating cellular balance ncrnas and rna interactions at the dominant of autophagy regulation in cancer |
| topic | autophagy miRNA lncRNA circRNA interaction cancer |
| url | https://www.mdpi.com/1422-0067/25/3/1561 |
| work_keys_str_mv | AT xueniyang orchestratingcellularbalancencrnasandrnainteractionsatthedominantofautophagyregulationincancer AT shizhengxiong orchestratingcellularbalancencrnasandrnainteractionsatthedominantofautophagyregulationincancer AT xinmiaozhao orchestratingcellularbalancencrnasandrnainteractionsatthedominantofautophagyregulationincancer AT jiamingjin orchestratingcellularbalancencrnasandrnainteractionsatthedominantofautophagyregulationincancer AT xinbingyang orchestratingcellularbalancencrnasandrnainteractionsatthedominantofautophagyregulationincancer AT yajingdu orchestratingcellularbalancencrnasandrnainteractionsatthedominantofautophagyregulationincancer AT linjiezhao orchestratingcellularbalancencrnasandrnainteractionsatthedominantofautophagyregulationincancer AT zhihenghe orchestratingcellularbalancencrnasandrnainteractionsatthedominantofautophagyregulationincancer AT chengjungong orchestratingcellularbalancencrnasandrnainteractionsatthedominantofautophagyregulationincancer AT liguo orchestratingcellularbalancencrnasandrnainteractionsatthedominantofautophagyregulationincancer AT tingmingliang orchestratingcellularbalancencrnasandrnainteractionsatthedominantofautophagyregulationincancer |