Modulation of neuronal signal transduction and memory formation by synaptic zinc
The physiological role of synaptic zinc has remained largely enigmatic since its initial detection in hippocampal mossy fibers over fifty years ago. The past few years have witnessed a number of studies highlighting the ability of zinc ions to regulate ion channels and intracellular signaling pathwa...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2011-11-01
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| Series: | Frontiers in Behavioral Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnbeh.2011.00068/full |
| _version_ | 1818367583819137024 |
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| author | Carlos eSindreu Daniel R Storm |
| author_facet | Carlos eSindreu Daniel R Storm |
| author_sort | Carlos eSindreu |
| collection | DOAJ |
| description | The physiological role of synaptic zinc has remained largely enigmatic since its initial detection in hippocampal mossy fibers over fifty years ago. The past few years have witnessed a number of studies highlighting the ability of zinc ions to regulate ion channels and intracellular signaling pathways implicated in neuroplasticity, and others that shed some light on the elusive role of synaptic zinc in learning and memory. Recent behavioral studies using knock out mice for the synapse-specific zinc transporter ZnT-3 indicate that vesicular zinc is required for the formation of memories dependent on the hippocampus and the amygdala, two brain centers that are prominently innervated by zinc-rich fibers. A common theme emerging from this research is the activity-dependent regulation of the Erk1/2 mitogen-activated-protein kinase pathway by synaptic zinc through diverse mechanisms in neurons. Here we discuss current knowledge on how synaptic zinc may play a role in cognition through its impact on neuronal signaling. |
| first_indexed | 2024-12-13T22:54:22Z |
| format | Article |
| id | doaj.art-3911874a170f44c6bdccd3265aa4ed6c |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-12-13T22:54:22Z |
| publishDate | 2011-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-3911874a170f44c6bdccd3265aa4ed6c2022-12-21T23:28:32ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532011-11-01510.3389/fnbeh.2011.0006814675Modulation of neuronal signal transduction and memory formation by synaptic zincCarlos eSindreu0Daniel R Storm1University of WashingtonUniversity of WashingtonThe physiological role of synaptic zinc has remained largely enigmatic since its initial detection in hippocampal mossy fibers over fifty years ago. The past few years have witnessed a number of studies highlighting the ability of zinc ions to regulate ion channels and intracellular signaling pathways implicated in neuroplasticity, and others that shed some light on the elusive role of synaptic zinc in learning and memory. Recent behavioral studies using knock out mice for the synapse-specific zinc transporter ZnT-3 indicate that vesicular zinc is required for the formation of memories dependent on the hippocampus and the amygdala, two brain centers that are prominently innervated by zinc-rich fibers. A common theme emerging from this research is the activity-dependent regulation of the Erk1/2 mitogen-activated-protein kinase pathway by synaptic zinc through diverse mechanisms in neurons. Here we discuss current knowledge on how synaptic zinc may play a role in cognition through its impact on neuronal signaling.http://journal.frontiersin.org/Journal/10.3389/fnbeh.2011.00068/fullHippocampusMemoryNeuronal PlasticitySignal Transductionsynaptic zinc |
| spellingShingle | Carlos eSindreu Daniel R Storm Modulation of neuronal signal transduction and memory formation by synaptic zinc Frontiers in Behavioral Neuroscience Hippocampus Memory Neuronal Plasticity Signal Transduction synaptic zinc |
| title | Modulation of neuronal signal transduction and memory formation by synaptic zinc |
| title_full | Modulation of neuronal signal transduction and memory formation by synaptic zinc |
| title_fullStr | Modulation of neuronal signal transduction and memory formation by synaptic zinc |
| title_full_unstemmed | Modulation of neuronal signal transduction and memory formation by synaptic zinc |
| title_short | Modulation of neuronal signal transduction and memory formation by synaptic zinc |
| title_sort | modulation of neuronal signal transduction and memory formation by synaptic zinc |
| topic | Hippocampus Memory Neuronal Plasticity Signal Transduction synaptic zinc |
| url | http://journal.frontiersin.org/Journal/10.3389/fnbeh.2011.00068/full |
| work_keys_str_mv | AT carlosesindreu modulationofneuronalsignaltransductionandmemoryformationbysynapticzinc AT danielrstorm modulationofneuronalsignaltransductionandmemoryformationbysynapticzinc |