Lipoprotein(a), family history of cardiovascular disease, and incidence of heart failure
Lipoprotein(a) (Lp(a)) is a largely genetically determined biomarker for cardiovascular disease (CVD), while its potential interplay with family history (FHx) of CVD, a measure of both genetic and environmental exposures, remains unclear. We examined the associations of Lp(a) in terms of circulating...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-07-01
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| Series: | Journal of Lipid Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227523000718 |
| _version_ | 1797776256321716224 |
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| author | Hai-Peng Wang Na Zhang Yu-Jie Liu Tian-Long Xia Guo-Chong Chen Jing Yang Fu-Rong Li |
| author_facet | Hai-Peng Wang Na Zhang Yu-Jie Liu Tian-Long Xia Guo-Chong Chen Jing Yang Fu-Rong Li |
| author_sort | Hai-Peng Wang |
| collection | DOAJ |
| description | Lipoprotein(a) (Lp(a)) is a largely genetically determined biomarker for cardiovascular disease (CVD), while its potential interplay with family history (FHx) of CVD, a measure of both genetic and environmental exposures, remains unclear. We examined the associations of Lp(a) in terms of circulating concentration or polygenetic risk score (PRS), and FHx of CVD with risk of incident heart failure (HF). Included were 299,158 adults from the UK Biobank without known HF and CVD at baseline. Hazards ratios (HRs) and 95% Cls were estimated by Cox regression models adjusted for traditional risk factors defined by the Atherosclerosis Risk in Communities study HF risk score. During the 11.8-year follow-up, 5,502 incidents of HF occurred. Higher levels of circulating Lp(a), Lp(a) PRS, and positive FHx of CVD were associated with higher risks of HF. Compared with individuals who had lower circulating Lp(a) and no FHx, HRs (95% CIs) of HF were 1.36 (1.25, 1.49), 1.31 (1.19, 1.43), and 1.42 (1.22, 1.67) for those with higher Lp(a) and a positive history of CVD for all family members, parents, and siblings, respectively; similar results were observed by using Lp(a) PRS. The risk estimates for HF associated with elevated Lp(a) and positive FHx were attenuated after excluding those with incident myocardial infarction (MI) during follow-up. Lp(a) and FHx of CVD were independent risk factors for incident HF, and the highest risk of HF was observed among individuals with both risk factors. The association may be partly mediated by myocardial infarction. |
| first_indexed | 2024-03-12T22:47:00Z |
| format | Article |
| id | doaj.art-3911bde25fab42c2ab30dcead171ca62 |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-03-12T22:47:00Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-3911bde25fab42c2ab30dcead171ca622023-07-21T04:57:38ZengElsevierJournal of Lipid Research0022-22752023-07-01647100398Lipoprotein(a), family history of cardiovascular disease, and incidence of heart failureHai-Peng Wang0Na Zhang1Yu-Jie Liu2Tian-Long Xia3Guo-Chong Chen4Jing Yang5Fu-Rong Li6Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, ChinaSchool of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Nutrition and Food Hygiene, School of Public Health, Suzhou Medical College of Soochow University, Suzhou, ChinaDivision of Public Health Emergency, Shenzhen Center for Disease Control and Prevention, Shenzhen, Guangdong, ChinaDepartment of Nutrition and Food Hygiene, School of Public Health, Suzhou Medical College of Soochow University, Suzhou, ChinaDepartment of Nutrition and Food Hygiene, School of Public Health, Suzhou Medical College of Soochow University, Suzhou, China; Department of Clinical Nutrition, The First Affiliated Hospital of Soochow University, Suzhou, China; For correspondence: Jing Yang; Fu-Rong LiShenzhen Key Laboratory of Cardiovascular Health and Precision Medicine, Southern University of Science and Technology, Shenzhen, China; School of Public Health and Emergency Management, Southern University of Science and Technology, Shenzhen, China; Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, China; For correspondence: Jing Yang; Fu-Rong LiLipoprotein(a) (Lp(a)) is a largely genetically determined biomarker for cardiovascular disease (CVD), while its potential interplay with family history (FHx) of CVD, a measure of both genetic and environmental exposures, remains unclear. We examined the associations of Lp(a) in terms of circulating concentration or polygenetic risk score (PRS), and FHx of CVD with risk of incident heart failure (HF). Included were 299,158 adults from the UK Biobank without known HF and CVD at baseline. Hazards ratios (HRs) and 95% Cls were estimated by Cox regression models adjusted for traditional risk factors defined by the Atherosclerosis Risk in Communities study HF risk score. During the 11.8-year follow-up, 5,502 incidents of HF occurred. Higher levels of circulating Lp(a), Lp(a) PRS, and positive FHx of CVD were associated with higher risks of HF. Compared with individuals who had lower circulating Lp(a) and no FHx, HRs (95% CIs) of HF were 1.36 (1.25, 1.49), 1.31 (1.19, 1.43), and 1.42 (1.22, 1.67) for those with higher Lp(a) and a positive history of CVD for all family members, parents, and siblings, respectively; similar results were observed by using Lp(a) PRS. The risk estimates for HF associated with elevated Lp(a) and positive FHx were attenuated after excluding those with incident myocardial infarction (MI) during follow-up. Lp(a) and FHx of CVD were independent risk factors for incident HF, and the highest risk of HF was observed among individuals with both risk factors. The association may be partly mediated by myocardial infarction.http://www.sciencedirect.com/science/article/pii/S0022227523000718family history of cardiovascular diseaseheart failureLipoprotein(a) |
| spellingShingle | Hai-Peng Wang Na Zhang Yu-Jie Liu Tian-Long Xia Guo-Chong Chen Jing Yang Fu-Rong Li Lipoprotein(a), family history of cardiovascular disease, and incidence of heart failure Journal of Lipid Research family history of cardiovascular disease heart failure Lipoprotein(a) |
| title | Lipoprotein(a), family history of cardiovascular disease, and incidence of heart failure |
| title_full | Lipoprotein(a), family history of cardiovascular disease, and incidence of heart failure |
| title_fullStr | Lipoprotein(a), family history of cardiovascular disease, and incidence of heart failure |
| title_full_unstemmed | Lipoprotein(a), family history of cardiovascular disease, and incidence of heart failure |
| title_short | Lipoprotein(a), family history of cardiovascular disease, and incidence of heart failure |
| title_sort | lipoprotein a family history of cardiovascular disease and incidence of heart failure |
| topic | family history of cardiovascular disease heart failure Lipoprotein(a) |
| url | http://www.sciencedirect.com/science/article/pii/S0022227523000718 |
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