Extrusion as a manufacturing process for polymer micro-tubes for various bio-medical applications
In various biomedical applications extrusion represents a common manufacturing process for polymeric semi-finished products. Extrusion allows the processing of a wide range of biomaterials, as well as different cross-sectional geometries. The present work focuses on the development of an extrusion p...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2019-09-01
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| Series: | Current Directions in Biomedical Engineering |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/cdbme-2019-0123 |
| _version_ | 1818580691304054784 |
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| author | Sahmel Olga Siewert Stefan Schmitz Klaus-Peter Arbeiter Daniela Grabow Niels Kreiner Christine Friederike Guthoff Rudolf |
| author_facet | Sahmel Olga Siewert Stefan Schmitz Klaus-Peter Arbeiter Daniela Grabow Niels Kreiner Christine Friederike Guthoff Rudolf |
| author_sort | Sahmel Olga |
| collection | DOAJ |
| description | In various biomedical applications extrusion represents a common manufacturing process for polymeric semi-finished products. Extrusion allows the processing of a wide range of biomaterials, as well as different cross-sectional geometries. The present work focuses on the development of an extrusion process for polymer micro-tubes used for medical devices manufacturing, e.g. microstents for minimally invasive glaucoma therapy. Semi-finished products were manufactured by means of extrusion and dip-coating. Morphology was investigated using biaxial laser measurement and scanning electron microscopy (SEM). For the analysis of mechanical and thermal properties of the specimens uniaxial tensile testing and differential scanning calorimetry (DSC) were performed. While dip-coated micro-tubes reveal a smooth and homogeneous surface, SEM micrographs of extruded micro-tubes exhibit some longitudinal grooves. Mechanical properties of extruded and dip-coated micro-tubes are comparable, so that the presented extrusion process can be regarded suitable for the manufacturing of polymer microtubes in a sub-millimeter scale. A future improvement of nozzle design will allow for a smooth surface of extruded semi-finished products. |
| first_indexed | 2024-12-16T07:21:37Z |
| format | Article |
| id | doaj.art-39127a23f915468aa3a10ec87a5d1b1c |
| institution | Directory Open Access Journal |
| issn | 2364-5504 |
| language | English |
| last_indexed | 2024-12-16T07:21:37Z |
| publishDate | 2019-09-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Current Directions in Biomedical Engineering |
| spelling | doaj.art-39127a23f915468aa3a10ec87a5d1b1c2022-12-21T22:39:37ZengDe GruyterCurrent Directions in Biomedical Engineering2364-55042019-09-015148949110.1515/cdbme-2019-0123cdbme-2019-0123Extrusion as a manufacturing process for polymer micro-tubes for various bio-medical applicationsSahmel Olga0Siewert Stefan1Schmitz Klaus-Peter2Arbeiter Daniela3Grabow Niels4Kreiner Christine Friederike5Guthoff Rudolf6Institute for Biomedical Engineering, Rostock University Medical Center, Friedrich- Barnewitz-Str. 4,Rostock, GermanyInstitute for ImplantTechnology and Biomaterials e.V., Friedrich-Barnewitz-Str. 4, 18119 Rostock-Warnemünde, GermanyInstitute for ImplantTechnology and Biomaterials e.V., Friedrich-Barnewitz-Str. 4, 18119 Rostock-Warnemünde, GermanyInstitute for Biomedical Engineering, Rostock University Medical Center, Friedrich-Barnewitz-Str. 4, 18119Rostock, GermanyInstitute for Biomedical Engineering, Rostock University Medical Center, Friedrich-Barnewitz-Str. 4, 18119Rostock, GermanyKreCo Kreiner Consulting Society for scientific and technical project management mbH, 16761Hennigsdorf, GermanyDepartment of Ophthalmology, Rostock University Medical Center, Doberaner Str. 140, 18057Rostock, GermanyIn various biomedical applications extrusion represents a common manufacturing process for polymeric semi-finished products. Extrusion allows the processing of a wide range of biomaterials, as well as different cross-sectional geometries. The present work focuses on the development of an extrusion process for polymer micro-tubes used for medical devices manufacturing, e.g. microstents for minimally invasive glaucoma therapy. Semi-finished products were manufactured by means of extrusion and dip-coating. Morphology was investigated using biaxial laser measurement and scanning electron microscopy (SEM). For the analysis of mechanical and thermal properties of the specimens uniaxial tensile testing and differential scanning calorimetry (DSC) were performed. While dip-coated micro-tubes reveal a smooth and homogeneous surface, SEM micrographs of extruded micro-tubes exhibit some longitudinal grooves. Mechanical properties of extruded and dip-coated micro-tubes are comparable, so that the presented extrusion process can be regarded suitable for the manufacturing of polymer microtubes in a sub-millimeter scale. A future improvement of nozzle design will allow for a smooth surface of extruded semi-finished products.https://doi.org/10.1515/cdbme-2019-0123extrusiondip-coatingpllachronosilmicrostentglaucoma drainage device |
| spellingShingle | Sahmel Olga Siewert Stefan Schmitz Klaus-Peter Arbeiter Daniela Grabow Niels Kreiner Christine Friederike Guthoff Rudolf Extrusion as a manufacturing process for polymer micro-tubes for various bio-medical applications Current Directions in Biomedical Engineering extrusion dip-coating plla chronosil microstent glaucoma drainage device |
| title | Extrusion as a manufacturing process for polymer micro-tubes for various bio-medical applications |
| title_full | Extrusion as a manufacturing process for polymer micro-tubes for various bio-medical applications |
| title_fullStr | Extrusion as a manufacturing process for polymer micro-tubes for various bio-medical applications |
| title_full_unstemmed | Extrusion as a manufacturing process for polymer micro-tubes for various bio-medical applications |
| title_short | Extrusion as a manufacturing process for polymer micro-tubes for various bio-medical applications |
| title_sort | extrusion as a manufacturing process for polymer micro tubes for various bio medical applications |
| topic | extrusion dip-coating plla chronosil microstent glaucoma drainage device |
| url | https://doi.org/10.1515/cdbme-2019-0123 |
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