Primary High-Grade Myxoid Liposarcoma of the Extremities: Prognostic Factors and Metastatic Pattern
(1) Background: This retrospective study aimed to analyze the history and treatment outcomes of localized, high-grade MLS of the extremities. (2) Methods: We retrospectively reviewed 82 patients with primary high-grade MLS of the extremities. OS, LRFS, MFS, PRS, and DFS were analyzed. (3) Results: F...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-05-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/11/2657 |
| _version_ | 1797493900012683264 |
|---|---|
| author | Gianmarco Tuzzato Roberta Laranga Federico Ostetto Elisa Bubbico Giulio Vara Giuseppe Bianchi |
| author_facet | Gianmarco Tuzzato Roberta Laranga Federico Ostetto Elisa Bubbico Giulio Vara Giuseppe Bianchi |
| author_sort | Gianmarco Tuzzato |
| collection | DOAJ |
| description | (1) Background: This retrospective study aimed to analyze the history and treatment outcomes of localized, high-grade MLS of the extremities. (2) Methods: We retrospectively reviewed 82 patients with primary high-grade MLS of the extremities. OS, LRFS, MFS, PRS, and DFS were analyzed. (3) Results: Five-year OS and LRS were 96% (95% CI: 86–98) and 94% (95% CI: 85–98), respectively. Statistical analysis indicated no risk factors for OS and LFRS. MFS was 77% (65–85) at 5-year follow-up. Size (<i>p</i> = 0.0337) was the only risk factor statistically significant for MFS (HR = 0.248, 95% CI: 0.07–0.84). Median PRS after distant metastasis was 34 months (range: 1–127 months). Five-year PRS was 79% (48–93). Overall, the 5-year DFS was 76% (65–85). (4) Conclusions: Patients with MLS were found to have a good prognosis. In high-grade deep-seated tumors, common risk factors for MLS do not correlate with survival. Tumor size appears to be the only predictor of long-term DSF and MSF. |
| first_indexed | 2024-03-10T01:26:36Z |
| format | Article |
| id | doaj.art-39143996f5554a22ac881aa99430579c |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T01:26:36Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-39143996f5554a22ac881aa99430579c2023-11-23T13:48:57ZengMDPI AGCancers2072-66942022-05-011411265710.3390/cancers14112657Primary High-Grade Myxoid Liposarcoma of the Extremities: Prognostic Factors and Metastatic PatternGianmarco Tuzzato0Roberta Laranga1Federico Ostetto2Elisa Bubbico3Giulio Vara4Giuseppe Bianchi5Unit of 3rd Orthopaedic and Traumatologic Clinic Prevalently Oncologic, IRCCS Istituto Ortopedico Rizzoli, Via Pupilli 1, 40136 Bologna, ItalyUnit of 3rd Orthopaedic and Traumatologic Clinic Prevalently Oncologic, IRCCS Istituto Ortopedico Rizzoli, Via Pupilli 1, 40136 Bologna, ItalyUnit of 3rd Orthopaedic and Traumatologic Clinic Prevalently Oncologic, IRCCS Istituto Ortopedico Rizzoli, Via Pupilli 1, 40136 Bologna, ItalyUnit of 3rd Orthopaedic and Traumatologic Clinic Prevalently Oncologic, IRCCS Istituto Ortopedico Rizzoli, Via Pupilli 1, 40136 Bologna, ItalyDepartment of Radiology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni 15, 40138 Bologna, ItalyUnit of 3rd Orthopaedic and Traumatologic Clinic Prevalently Oncologic, IRCCS Istituto Ortopedico Rizzoli, Via Pupilli 1, 40136 Bologna, Italy(1) Background: This retrospective study aimed to analyze the history and treatment outcomes of localized, high-grade MLS of the extremities. (2) Methods: We retrospectively reviewed 82 patients with primary high-grade MLS of the extremities. OS, LRFS, MFS, PRS, and DFS were analyzed. (3) Results: Five-year OS and LRS were 96% (95% CI: 86–98) and 94% (95% CI: 85–98), respectively. Statistical analysis indicated no risk factors for OS and LFRS. MFS was 77% (65–85) at 5-year follow-up. Size (<i>p</i> = 0.0337) was the only risk factor statistically significant for MFS (HR = 0.248, 95% CI: 0.07–0.84). Median PRS after distant metastasis was 34 months (range: 1–127 months). Five-year PRS was 79% (48–93). Overall, the 5-year DFS was 76% (65–85). (4) Conclusions: Patients with MLS were found to have a good prognosis. In high-grade deep-seated tumors, common risk factors for MLS do not correlate with survival. Tumor size appears to be the only predictor of long-term DSF and MSF.https://www.mdpi.com/2072-6694/14/11/2657liposarcoma myxoidmetastaseshigh gradeextremities |
| spellingShingle | Gianmarco Tuzzato Roberta Laranga Federico Ostetto Elisa Bubbico Giulio Vara Giuseppe Bianchi Primary High-Grade Myxoid Liposarcoma of the Extremities: Prognostic Factors and Metastatic Pattern Cancers liposarcoma myxoid metastases high grade extremities |
| title | Primary High-Grade Myxoid Liposarcoma of the Extremities: Prognostic Factors and Metastatic Pattern |
| title_full | Primary High-Grade Myxoid Liposarcoma of the Extremities: Prognostic Factors and Metastatic Pattern |
| title_fullStr | Primary High-Grade Myxoid Liposarcoma of the Extremities: Prognostic Factors and Metastatic Pattern |
| title_full_unstemmed | Primary High-Grade Myxoid Liposarcoma of the Extremities: Prognostic Factors and Metastatic Pattern |
| title_short | Primary High-Grade Myxoid Liposarcoma of the Extremities: Prognostic Factors and Metastatic Pattern |
| title_sort | primary high grade myxoid liposarcoma of the extremities prognostic factors and metastatic pattern |
| topic | liposarcoma myxoid metastases high grade extremities |
| url | https://www.mdpi.com/2072-6694/14/11/2657 |
| work_keys_str_mv | AT gianmarcotuzzato primaryhighgrademyxoidliposarcomaoftheextremitiesprognosticfactorsandmetastaticpattern AT robertalaranga primaryhighgrademyxoidliposarcomaoftheextremitiesprognosticfactorsandmetastaticpattern AT federicoostetto primaryhighgrademyxoidliposarcomaoftheextremitiesprognosticfactorsandmetastaticpattern AT elisabubbico primaryhighgrademyxoidliposarcomaoftheextremitiesprognosticfactorsandmetastaticpattern AT giuliovara primaryhighgrademyxoidliposarcomaoftheextremitiesprognosticfactorsandmetastaticpattern AT giuseppebianchi primaryhighgrademyxoidliposarcomaoftheextremitiesprognosticfactorsandmetastaticpattern |